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Category: coloring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 250.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 753.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 552.00 °F. TCC ( 289.00 °C. ) (est)
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| logP (o/w): | 0.560 (est) |
| Soluble in: |
| | water, 600 mg/L @ 20 °C (exp) | | | water, 4.511e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | coloring agents |
| Recommendation for hematein usage levels up to: | | | not for fragrance use.
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| Recommendation for hematein flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 475-25-2 |
| Pubchem (cid): | 10138 |
| Pubchem (sid): | 134973145 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benz(b)indeno(1,2-d)pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy- | | | benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy- | | 6a,7- | dihydro-3,4,6a,10-tetrahydroxybenz(b)indeno(1,2-d)pyran-9(6H)-one | | 6a,7- | dihydro-3,4,6a,10-tetrahydroxybenz[b]indeno[1,2-d]pyran-9(6H)-one | | | haematein | | | hematine | | | hydroxybrasilein | | | hydroxybrazilein | | 3,4,6a,10- | tetrahydroxy-6,7-dihydroindeno[2,1-c]chromen-9-one | | 3,4,6a,10- | tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6H)-one | | 3,4,6a,10- | tetrahydroxy-6a,7-dihydroindeno[2,1-c]chromen-9(6H)-one | | 3,4,10,6a- | tetrahydroxy-7,6a-dihydroindeno[2,1-c]chroman-9-one |
Articles:
| PubMed: | [Application of fluorescence probe marked by quantum dots to detect early submandibular lymph node metastasis in a nude mouse model]. |
| PubMed: | A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase. |
| PubMed: | [Effects of periodontal mechanical therapy with local and systemic drugs on carotid artery and serum high-sensitivity C-reactive protein in rats with chronic periodontitis associated with atherosclerosis]. |
| PubMed: | Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. |
| PubMed: | [A comparative study on apexification using different kinds of materials in dogs]. |
| PubMed: | [The effect of modified bone morphogenetic protein-2 polylactic acid nanospheres sustained-release system on promoting mandibular defect repair]. |
| PubMed: | The hypoglycemic effect of the kelp on diabetes mellitus model induced by alloxan in rats. |
| PubMed: | A new use for an old method: the Woelcke myelin stain for counting degenerating neurons in the brain of mice following status epilepticus. |
| PubMed: | Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants. |
| PubMed: | [Pulp revascularization of immature anterior teeth with apical periodontitis]. |
| PubMed: | An enzyme-free highly glucose-specific assay using self-assembled aminobenzene boronic acid upon polyelectrolytes electrospun nanofibers-mat. |
| PubMed: | An amperometric penicillin biosensor with enhanced sensitivity based on co-immobilization of carbon nanotubes, hematein, and beta-lactamase on glassy carbon electrode. |
| PubMed: | Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model. |
| PubMed: | Nuclear staining with alum hematoxylin. |
| PubMed: | Hematein chelates of unusual metal ions for tinctorial histochemistry. |
| PubMed: | Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. |
| PubMed: | A special issue devoted to hematoxylin, hematein, and hemalum. |
| PubMed: | Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. |
| PubMed: | An amperometric urea biosensor based on covalently immobilized urease on an electrode made of hyperbranched polyester functionalized gold nanoparticles. |
| PubMed: | Urea biosensor based on amperometric pH-sensing with hematein as a pH-sensitive redox mediator. |
| PubMed: | Negative ion electrospray mass spectrometry of neoflavonoids. |
| PubMed: | The precise location and nature of the nerves to the male human urethra: histological and immunohistochemical studies with three-dimensional reconstruction. |
| PubMed: | An amperometric urea biosensor based on covalent immobilization of urease onto an electrochemically prepared copolymer poly (N-3-aminopropyl pyrrole-co-pyrrole) film. |
| PubMed: | [The uteropelvic junction in children: from the clinical problems to the morphogenetic approach]. |
| PubMed: | Anatomical histological and mesoscopic study of the adipose tissue of the orbit. |
| PubMed: | [Organization and innervation of striated muscle fibers of the striated sphincter in the rat]. |
| PubMed: | Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice. |
| PubMed: | Pharmacological action and therapeutic effects of glutathione on hypokinetic spermatozoa for enzymatic-dependent pathologies and correlated genetic aspects. |
| PubMed: | Determination of ATP via the photochemical generation of hydrogen peroxide using flow injection luminol chemiluminescence detection. |
| PubMed: | Staining of intestinal protozoa with Heidenhain's iron hematoxylin. |
| PubMed: | Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression. |
| PubMed: | Comparison of historic GrĂ¼bler dyes with modern counterparts. |
| PubMed: | Hematein inhibits tumor necrotic factor-alpha-induced vascular cell adhesion molecule-1 and NF-kappaB-dependent gene expression in human vascular endothelial cells. |
| PubMed: | Morphometric study of the upper intercostal nerves: practical application for neurotizations in traumatic brachial plexus palsies. |
| PubMed: | [VCS microclip anastomosis on blood vessels of less than 2 millimeters in diameter. Preliminary experimental study in the rat]. |
| PubMed: | Hematoxylin staining in quantitative DNA cytometry: an image analysis study. |
| PubMed: | A quick-mixed aluminum hematoxylin stain. |
| PubMed: | New investigations on hematoxylin, hematein, and hematein-aluminium complexes. II. Hematein-aluminium complexes and hemalum staining. |
| PubMed: | New investigations on hematoxylin, hematein, and hematein-aluminium complexes. I. Spectroscopic and physico-chemical properties of hematoxylin and hematein. |
| PubMed: | [Colo-rectal spirochetosis: is it an anatomo-pathologic entity?]. |
| PubMed: | [Edema inhibiting effect of indenochromene derivatives from natural sources]. |
| PubMed: | Localization of phospholipids in human catecholamine neurons with Baker's acid haematein. |
| PubMed: | [Mechanisms of the inhibition of Fe2+-induced oxidation of phosphatidylcholine by polyhydroxynaphthoquinones]. |
| PubMed: | Effects of the metal salts on the staining of elastic fibers with hematein. |
| PubMed: | Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. |
| PubMed: | Effect of formalin pigment removal on peroxidase-antiperoxidase immunoperoxidase technique. |
| PubMed: | Application of current chemical concepts to metal-hematein and -brazilein stains. |
| PubMed: | A histological assessment of the four-day subrenal capsule assay (SRCA). |
| PubMed: | [Cellular aspects of the aging of the articular cartilage. II. Condylar cartilage with fissured surface taken from normal and arthritic knees]. |
| PubMed: | A four-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors. |
| PubMed: | Studies on Papanicolaou staining. III. Quantitative investigations of orangeophilia and cyanophilia. |
| PubMed: | Papanicolaou staining--a review. |
| PubMed: | Chemical aspects of santalin as a histological stain. |
| PubMed: | The effect of sexual hormones on the lipid and proteinaceous secretion of the rat preputial sebaceous gland. |
| PubMed: | Studies on Papanicolaou staining. II. Quantitation of dye components bound to cervical cells. |
| PubMed: | On the mechanism of Verhoeff's elastica stain: a convenient stain for myelin sheaths. |
| PubMed: | Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry. |
| PubMed: | Assessment of the heart by histochemical and birefringence techniques as compared with ventricular function tests. |
| PubMed: | On elastic fibers stain with hematein and its staining mechanism. |
| PubMed: | Histochemical studies on metachromatic mucin stain with hematein. |
| PubMed: | [Histological application of hematein by means of Arshid's method with special reference to staining of mucosubstances, elastic fibers and collagenous fibers]. |
| PubMed: | [Hematin treatment of porphyric neuropathy]. |
| PubMed: | [Myocardium in valvular cardiopathies. Ultrastructural and histoenzymological changes. Functional correlations]. |
| PubMed: | [On the hematein staining--comparative studies with hematoxylin staining (author's transl)]. |
| PubMed: | Histochemical and structural changes in human myocardial cells after cardiopulmonary bypass. |
| PubMed: | Thin layer chromatography of certain preformed metal complex dyes used in biological staining. |
| PubMed: | Effects of additives on alum hematoxylin staining solutions. |
| PubMed: | Lipid droplets in the heart interstitium: concentration and distribution. |
| PubMed: | Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants. |
| PubMed: | A simple assay procedure for mixtures of hematoxylin and hematein. |
| PubMed: | Cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications. |
| PubMed: | A technique combining Baker's acid hematein and Hadjioloff's hydrotropic sudan 3 stains for identification of choline-containing phospholipids within the same tissue section. |
| PubMed: | The staining and chromium binding of rat brain tissue and of lipids in model systems subjected to Baker's acid hematein technique. |
| PubMed: | Assaying actual hematein content of commercial hematoxylins and hemateins. |
| PubMed: | Studies on metallochromic indicators-III Hematoxylin and hematein. |
| PubMed: | The acid hematein stain and myocardial damage. |
| PubMed: | [Comparative studies on phospholipid demonstration with Baker's acid hematein test and the method of Bourgeois and Hubbard]. |
| PubMed: | [Histochemical studies with the acid hematein test according to Baker on pathologically changed skin. VI. Adipose tissue tumors and fat cells in other tumors]. |
| PubMed: | [HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICAL SKIN. IV. NEVUS CELL NEVUS, PREBLASTOMATOUS MELANOSIS AND MELANOCYTE BLASTOMA]. |
| PubMed: | On the mechanism of sequence iron-hematein stains. |
| PubMed: | The reaction of unsaturated fats with the acid hematein test. |
| PubMed: | [HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. 3. DENDRITE CELLS OF THE EPITHELIUM]. |
| PubMed: | [HISTOCHEMICAL STUDIES WITH BAKER'S ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. II. MOLLUSCUM CONTAGIOSUM, VERRUCA VULGARIS AND CONDYLOMA ACUMINATUM]. |
| PubMed: | [HISTOCHEMICAL STUDIES WITH THE BAKER ACID HEMATEIN TEST ON NORMAL AND PATHOLOGICALLY CHANGED SKIN. I. NORMAL SKIN]. |
| PubMed: | A SIMPLIFIED ACID HEMATEIN TEST FOR PHOSPHOLIPIDS. |
| PubMed: | Experimental and cytological studies of pineal cells staining with acid hematein in the rat (Rattus norvegicus). |
| PubMed: | Acid hematein staining of uterine neoplastic tissues. |
| PubMed: | Cytochemical studies on tumor cells. III. Two types of tumor cells as revealed by the acid hematein test. |
| PubMed: | Cytochemical studies on tumor cells. II. Localization of phospholipids in normal and neoplastic tissues, as revealed by the acid hematein test. |
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