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2,3-butanediol, 1,4-dimercapto-, (R-(R*,R*))- (9CI)
Notes:
a reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of sh (thiol) groups and for reducing disulphides to dithiols. Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT has an epimeric compound, dithioerythritol.
A common use of DTT is as a reducing or "deprotecting" agent for thiolated DNA. DTT is frequently used to reduce the disulfide bonds of proteins and, more generally, to prevent intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins.
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): DITHIOTHREITOL
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| CAS Number: | 3483-12-3 |  3D/inchi
|
| Other(deleted CASRN): | 1377983-58-8 | |
| ECHA EINECS - REACH Pre-Reg: | 222-468-7 | |
| FDA UNII: | T8ID5YZU6Y | |
| Nikkaji Web: | J307.897C | |
| Beilstein Number: | 1719757 | |
| MDL: | MFCD00004877 | |
| XlogP3-AA: | -0.40 (est) | |
| Molecular Weight: | 154.25210000 | |
| Formula: | C4 H10 O2 S2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 42.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 364.50 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 346.00 °F. TCC ( 174.20 °C. ) (est) |
| logP (o/w): | 0.070 (est) |
| Soluble in: | |
| water, 1.856e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
hair straightening agents hair waving agents reducing agents |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 1,4-Dithio-DL-threitol,Threo-1,4-dimercapto-2,3-butandiol,Threo-2,3-dihydroxy-1,4-dithiobutane,1,4-Dithiothreitol,Cleland's reagent,DTT |
| Charkit Chemical |
| DITHIOTHREITOL |
| Glentham Life Sciences |
| DL-Dithiothreitol, 99% |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| DL-Dithiothreitol |
| TCI AMERICA |
| For experimental / research use only. |
| DL-Dithiothreitol >98.0%(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intramuscular-mouse LD50 108 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949. intraperitoneal-mouse LD50 154 mg/kg Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1419, 1974. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | cosmetic agents | ||
| Recommendation for dithiothreitol usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for dithiothreitol flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 3483-12-3 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 19001 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 1,4-bis(sulfanyl)butane-2,3-diol | |
| Chemidplus: | 0003483123 |
| RTECS: | EK1610000 for cas# 3483-12-3 |
References:
| 1,4-bis(sulfanyl)butane-2,3-diol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 3483-12-3 |
| Pubchem (cid): | 19001 |
| Pubchem (sid): | 134985466 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C00265 |
| HMDB (The Human Metabolome Database): | HMDB13593 |
| FooDB: | FDB029593 |
| YMDB (Yeast Metabolome Database): | YMDB01407 |
| Export Tariff Code: | 2930.90.9190 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 2,3- | butanediol, 1,4-dimercapto- |
| 2,3- | butanediol, 1,4-dimercapto-, (R-(R*,R*))- (9CI) |
| 2,3- | butanediol, 1,4-dimercapto-, (R*,R*)- |
| 2,3- | butanediol, 1,4-dimercapto-, DL-threo- |
| 2,3- | butanediol, 1,4-dimercapto, (R*,R*)- |
| threo-2,3- | dihydroxy-1,4-butanedithiol |
| (±)-1,4- | dimercapto-2,3-butanediol |
| (±)-threo-1,4- | dimercapto-2,3-butanediol |
| (R*,R*)-(±)-1,4- | dimercapto-2,3-butanediol |
| (R*,R*)-1,4- | dimercapto-2,3-butanediol |
| 1,4- | dimercapto-2,3-butanediol |
| DL-theo-1,4- | dimercapto-2,3-butanediol |
| threo-1,4- | dimercapto-2,3-butanediol |
| (R-(R*,R*))-1,4- | dimercaptobutane-2,3-diol |
| (R*,R*)-(1)-1,4- | dimercaptobutane-2,3-diol |
| (R*,R*)-1,4- | dimercaptobutane-2,3-diol |
| [R-(R*,R*)]-1,4- | dimercaptobutane-2,3-diol |
| 1,4- | dimercaptobutane-2,3-diol |
| 1,4- | disulfanyl-2,3-butanediol |
| 1,4- | disulfanyl-2,3-butanediol, DL, threo- |
| 1,4- | disulfanylbutane-2,3-diol |
| 1,4- | dithio-DL-threitol |
| 1,4- | dithioerythritol |
| (±)- | dithiothreitol |
| 1,4- | dithiothreitol |
| DL- | dithiothreitol |
| DL-1,4- | dithiothreitol |
| erythritol, 1,4-dithio- | |
| erythro-1,4-dimercapto-2,3-butanediol | |
| 1,4-bis( | sulfanyl)butane-2,3-diol |
| 1,4-bis | sulfanylbutane-2,3-diol |
| threitol, 1,4-dithio-, DL- |