schizandrin C
1,3-benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-
 
Notes:
None found
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
      Email: Marketing
      US Email: Marketing
      Email: Sales
      US Email: Sales
      Voice: 1-631-485-4226
      Fax: 1-631-614-7828
      US Voice: 1-631-485-4226
      US Fax: 1-631-614-7828
      Europe44-203-286-1088
      Facebook
      Twitter
      Linkedin
      Blog
      Get the App!
      Product(s):
      61301-33-5 schisandrin C >98%
      Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill, which shows anticancer-effects in human leukemia U937 cells.
       
       
Synonyms   Articles   Notes   Search
CAS Number: 61301-33-5Picture of molecule3D/inchi
FDA UNII: C8754W6B3G
Nikkaji Web: J431.366F
MDL: MFCD00272170
XlogP3-AA: 5.00 (est)
Molecular Weight: 384.42848000
Formula: C22 H24 O6
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 549.15 °C. @ 760.00 mm Hg (est)
Flash Point: 440.00 °F. TCC ( 226.70 °C. ) (est)
logP (o/w): 5.623 (est)
Soluble in:
 water, 0.0004255 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Schisandrin C 98%
BOC Sciences
For experimental / research use only.
schisandrin C >98%
Odor: characteristic
Use: Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill, which shows anticancer-effects in human leukemia U937 cells.
Nacalai USA
For experimental / research use only.
Wuweizisu C
Sigma-Aldrich: Sigma
For experimental / research use only.
Schizandrin C ≥98% (HPLC)
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo  2000 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Chinese Medical Journal Vol. 93, Pg. 41, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: natural substances and extractives
Recommendation for schizandrin C usage levels up to:
 not for fragrance use.
 
Recommendation for schizandrin C flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 119112
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0061301335
RTECS: GX9500000 for cas# 61301-33-5
Synonyms   Articles   Notes   Search   Top
References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 119112
Pubchem (sid): 135074599
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 schisandra incarnata
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
1,3-benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-
13,14-dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole
 schisandrin C
 wuweizisu C
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: [Correlation study on lignin contents of Schisandra chinensis and ecological factors].
PubMed: Comprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometrics.
PubMed: Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia.
PubMed: Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells.
PubMed: Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.
PubMed: Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells.
PubMed: Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts.
PubMed: A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera.
PubMed: Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis.
PubMed: Synthesis and biological activity of Wuweizisu C and analogs.
PubMed: [Study on the chemical constituents of the fruit handles from Schizandra chinensis].
PubMed: Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells.
PubMed: Bicyclol: a novel drug for treating chronic viral hepatitis B and C.
PubMed: Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells.
PubMed: Transport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers - an in-vitro model of intestinal transport.
PubMed: Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae.
PubMed: Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.
PubMed: New synthesis of (S)-dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethenedioxy-biphenyl-2,2'-dicarboxylate by configuration transform.
PubMed: [Studies on chemical constituents of Schisandra propinqua (Wall.) Hook. f. et Thoms].
PubMed: New drugs derived from medicinal plants.
PubMed: Solubilization of biphenyl dimethyl dicarboxylate by cosolvency.
PubMed: Structure-activity relationship of schisandrins in enhancing liver mitochondrial glutathione status in CCl4-poisoned mice.
PubMed: Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats.
PubMed: Adaptogenic screening in rats.
PubMed: Induction of liver microsomal cytochrome P-450 2B1 by dimethyl diphenyl bicarboxylate in rats.
PubMed: Gomisin A inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
PubMed: Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity.
PubMed: [Determination of the active ingredients in Chinese drug wuweizi (Schisandra chinensis) by TLC-densitometry].
PubMed: Scavenging effects on active oxygen radicals by schizandrins with different structures and configurations.
PubMed: Pharmacological actions and clinical use of fructus schizandrae.
PubMed: [Biochemical and pharmacologic effects of wuweizi (Schizandra chinensis (Turcz.) Baill.) and its chemical contents on animal livers].
PubMed: The effect of DDB on dystrophic hamsters: an in vivo and in vitro study.
PubMed: Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A.
PubMed: [Pharmacological studies on schizandra fruits. III. Effects of wuweizisu C, a lignan component of schizandra fruits, on experimental liver injuries in rats].
PubMed: Studies on antihepatitic drugs. Total synthesis of (+/-)schizandrin C and its analogs.
PubMed: Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids.
PubMed: Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity.
PubMed: [Synthesis of schizandrin C analogs. II. Synthesis of dimethyl-4, 4'-dimethoxy-5, 6, 5', 6'- dimethylenedioxybiphenyl-2, 2'-dicarboxylate and its isomers (author's transl)].
PubMed: [Synthesis of Schizandrin C analogs (author's transl)].
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2021 Perflavory ™ Disclaimer Privacy Policy