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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 861.70 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 581.00 °F. TCC ( 305.00 °C. ) (est)
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| logP (o/w): | 2.670 (est) |
| Soluble in: |
| | water, 36.86 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for (-)-catechin gallate usage levels up to: | | | not for fragrance use.
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| Recommendation for (-)-catechin gallate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | [(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6419835 |
| Pubchem (sid): | 135275395 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 3,4,5-trihydroxy-, (2S,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester | | (-)- | catechingallate | | (2S,3R)-2-(3,4- | dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate) | | (2S,3R)-2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate | | (2S,3R)-2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate | | [(2S,3R)-2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate | | (2S,3R)-2-(3,4- | dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate |
Articles:
| PubMed: | Effect of the type of brewing water on the chemical composition, sensory quality and antioxidant capacity of Chinese teas. |
| PubMed: | Metabolomics analysis reveals the metabolic and functional roles of flavonoids in light-sensitive tea leaves. |
| PubMed: | Tea polyphenols dominate the short-term tea (Camellia sinensis) leaf litter decomposition. |
| PubMed: | Ultraviolet B (UVB) Photosensitivities of Tea Catechins and the Relevant Chemical Conversions. |
| PubMed: | Impact of Clonal Variability on Phenolics and Radical Scavenging Activity of Grapes and Wines: A Study on the Recently Developed Merlot and Cabernet Franc Clones (Vitis vinifera L.). |
| PubMed: | Inhibitory Effects of Eight Green Tea Catechins on Cytochrome P450 1A2, 2C9, 2D6, and 3A4 Activities. |
| PubMed: | Mineral and metabolic profiles in tea leaves and flowers during flower development. |
| PubMed: | Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses. |
| PubMed: | Screening and Toxicity Analysis of Catechin Isomers Against FemA Protein. |
| PubMed: | Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. |
| PubMed: | Association of Catechin Molecules in Water: Quantitative Binding Study and Complex Structure Analysis. |
| PubMed: | Determination and quality evaluation of green tea extracts through qualitative and quantitative analysis of multi-components by single marker (QAMS). |
| PubMed: | Neuroprotection by epigallo catechin gallate against bupivacaine anesthesia induced toxicity involves modulation of PI3/Akt/PTEN signalling in N2a and SH-SY5Y cells. |
| PubMed: | Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry. |
| PubMed: | In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2. |
| PubMed: | Structure-dependent inhibitory effects of green tea catechins on insulin secretion from pancreatic β-cells. |
| PubMed: | Polyphenols: well beyond the antioxidant capacity: gallic acid and related compounds as neuroprotective agents: you are what you eat! |
| PubMed: | Optimization of subcritical water extraction of flavanols from green tea leaves. |
| PubMed: | Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins. |
| PubMed: | In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-β-D-glucose plays a vital role in anti-tumour activity. |
| PubMed: | UHPLC determination of catechins for the quality control of green tea. |
| PubMed: | Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes. |
| PubMed: | Chromenylchalcones showing cytotoxicity on human colon cancer cell lines and in silico docking with aurora kinases. |
| PubMed: | Effects of catechin polyphenols and preparations from the plant-parasitic nematode Heterodera glycines on protease activity and behaviour in three nematode species. |
| PubMed: | Epigallocatechin-3-gallate is a potent phytochemical inhibitor of intimal hyperplasia in the wire-injured carotid artery. |
| PubMed: | Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. |
| PubMed: | Role of catechins in the antioxidant capacity of an active film containing green tea, green coffee, and grapefruit extracts. |
| PubMed: | Inhibitory effects of daiokanzoto (da-huang-gan-cao-tang) on p-glycoprotein. |
| PubMed: | Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. |
| PubMed: | Identification and characterization of proanthocyanidins of 16 members of the Rhododendron genus (Ericaceae) by tandem LC-MS. |
| PubMed: | Engineering the production of major catechins by Escherichia coli carrying metabolite genes of Camellia sinensis. |
| PubMed: | A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide. |
| PubMed: | Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation. |
| PubMed: | Epicatechin-3-O-(3″-O-methyl)-gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release. |
| PubMed: | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. |
| PubMed: | [Study on extraction process of available components of tea]. |
| PubMed: | Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins. |
| PubMed: | Configurational studies of complexes of various tea catechins and caffeine in crystal state. |
| PubMed: | Effect of girdling at various positions of 'Huang Zhi Xiang' tea tree (Camellia sinensis) on the contents of catechins and starch in fresh leaf. |
| PubMed: | Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. |
| PubMed: | The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors. |
| PubMed: | Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. |
| PubMed: | Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum. |
| PubMed: | Comparison of the nutrient and chemical contents of traditional Korean Chungtaejeon and green teas. |
| PubMed: | Dietary flavonoids activate the constitutive androstane receptor (CAR). |
| PubMed: | Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT. |
| PubMed: | Effect of girdling on levels of catechins in fresh leaf in relation to quality of 'Huang Zhi Xiang' Oolong' tea. |
| PubMed: | Induction of apoptosis by immature plum in human hepatocellular carcinoma. |
| PubMed: | Mitochondrial alterations in aging rat brain: effective role of (-)-epigallo catechin gallate. |
| PubMed: | (-)Epigallocatechin-3-gallate inhibits the spontaneous firing of rat locus coeruleus neuron. |
| PubMed: | Efficient procedure for isolating methylated catechins from green tea and effective simultaneous analysis of ten catechins, three purine alkaloids, and gallic acid in tea by high-performance liquid chromatography with diode array detection. |
| PubMed: | Comparative neuroprotective properties of stilbene and catechin analogs: action via a plasma membrane receptor site? |
| PubMed: | Determination of extractability of pine bark using supercritical CO(2) extraction and different solvents: optimization and prediction. |
| PubMed: | A new phenylpropanoid derivative of catechin from the needles of Taxus cuspidata. |
| PubMed: | Antioxidants from steamed used tea leaves and their reaction behavior. |
| PubMed: | Total antioxidant capacity and content of flavonoids and other phenolic compounds in canihua (Chenopodium pallidicaule): an Andean pseudocereal. |
| PubMed: | Multifunctional effects of green tea catechins on prevention of the metabolic syndrome. |
| PubMed: | Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue. |
| PubMed: | Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines. |
| PubMed: | The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins. |
| PubMed: | Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. |
| PubMed: | Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC. |
| PubMed: | Identification of major phenolic compounds of Chinese water chestnut and their antioxidant activity. |
| PubMed: | Isomeric differentiation of green tea catechins using gas-phase hydrogen/deuterium exchange reactions. |
| PubMed: | Epigallocatechin gallate-induced apoptosis does not affect adipocyte conversion of preadipocytes. |
| PubMed: | In vitro cytotoxicity of (-)-catechin gallate, a minor polyphenol in green tea. |
| PubMed: | Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase. |
| PubMed: | Effect of molecular structure of phenolic families as hydroxycinnamic acids and catechins on their antioxidant effectiveness in minced fish muscle. |
| PubMed: | Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins. |
| PubMed: | Neuroprotective effects of natural products: interaction with intracellular kinases, amyloid peptides and a possible role for transthyretin. |
| PubMed: | Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells. |
| PubMed: | Attomole catechins determination by capillary liquid chromatography with electrochemical detection. |
| PubMed: | Flavonoid content of U.S. fruits, vegetables, and nuts. |
| PubMed: | Synthesis and preliminary anticancer activity studies of C4 and C8-modified derivatives of catechin gallate (CG) and epicatechin gallate (ECG). |
| PubMed: | Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. |
| PubMed: | Enzymatic O-methylation of flavanols changes lag time, propagation rate, and total oxidation during in vitro model triacylglycerol-rich lipoprotein oxidation. |
| PubMed: | Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. |
| PubMed: | Inhibition of fatty acid synthase by polyphenols. |
| PubMed: | Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins. |
| PubMed: | Rational design of anticytoadherence inhibitors for Plasmodium falciparum based on the crystal structure of human intercellular adhesion molecule 1. |
| PubMed: | Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. |
| PubMed: | Catechin derivatives: specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels. |
| PubMed: | Inhibition of growth, induction of apoptosis and alteration of gene expression by tea polyphenols in the highly metastatic human lung cancer cell line NCI-H460. |
| PubMed: | Inhibitory effects of catechin gallates on o-methyltranslation of protocatechuic acid in rat liver cytosolic preparations and cultured hepatocytes. |
| PubMed: | Separation of catechin constituents from five tea cultivars using high-speed counter-current chromatography. |
| PubMed: | Determination of proanthocyanidins in fresh grapes and grape products using liquid chromatography with mass spectrometric detection. |
| PubMed: | [Determination of catechins and caffeine in tea and tea beverages by high-performance liquid chromatography]. |
| PubMed: | Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. |
| PubMed: | Novel inhibitors of fatty-acid synthase from green tea (Camellia sinensis Xihu Longjing) with high activity and a new reacting site. |
| PubMed: | Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats. |
| PubMed: | Antimutagenic properties of green tea. |
| PubMed: | Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. |
| PubMed: | Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. |
| PubMed: | Tannins and catechin gallate mediate the vasorelaxant effect of Arbutus unedo on the rat isolated aorta. |
| PubMed: | New apoptosis cascade mediated by lysosomal enzyme and its protection by epigallo-catechin gallate. |
| PubMed: | Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. |
| PubMed: | Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction. |
| PubMed: | Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography. |
| PubMed: | Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors. |
| PubMed: | Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. |
| PubMed: | Flavonoids from Argentine Tagetes (Asteraceae) with antimicrobial activity. |
| PubMed: | Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates. |
| PubMed: | Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis. |
| PubMed: | Vascular actions of the polyphenolic catechin gallate EGCG: endothelium-dependent contraction and relaxation. |
| PubMed: | Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins. |
| PubMed: | Proanthocyanidin composition in the seed coat of lentils (Lens culinaris L.). |
| PubMed: | Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate. |
| PubMed: | Effect of flavan-3-ols on in vitro egg hatching, larval development and viability of infective larvae of Trichostrongylus colubriformis. |
| PubMed: | Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. |
| PubMed: | Green tea catechins as a BACE1 (beta-secretase) inhibitor. |
| PubMed: | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. |
| PubMed: | Determination of proanthocyanidins in grape products by liquid chromatography/mass spectrometric detection under low collision energy. |
| PubMed: | Complex effects of different green tea catechins on human platelets. |
| PubMed: | Inhibitory effects of green tea catechins on the activity of human matrix metalloproteinase 7 (matrilysin). |
| PubMed: | Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. |
| PubMed: | [Study on the analytical methods of catechins in tea and green tea polyphenol samples by high performance liquid chromatography]. |
| PubMed: | Effects of catechins on vascular tone in rat thoracic aorta with endothelium. |
| PubMed: | Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity. |
| PubMed: | Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. |
| PubMed: | Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins. |
| PubMed: | Effects of dietary antioxidants on human DNA ex vivo. |
| PubMed: | Green tea and its catechins inhibit breast cancer xenografts. |
| PubMed: | Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. |
| PubMed: | Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. |
| PubMed: | Hydrogen peroxide and flavan-3-ols in storage roots of cassava (Manihot esculenta crantz) during postharvest deterioration. |
| PubMed: | Effects of heat processing and storage on flavanols and sensory qualities of green tea beverage. |
| PubMed: | Biochemical characterization of casein kinase II as a protein kinase responsible for stimulation of HIV-1 protease in vitro. |
| PubMed: | Determination of catechins in human urine subsequent to tea ingestion by high-performance liquid chromatography with electrochemical detection. |
| PubMed: | Comparative analysis of tea catechins and theaflavins by high-performance liquid chromatography and capillary electrophoresis. |
| PubMed: | Effects of green tea catechins on membrane fluidity. |
| PubMed: | Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals. |
| PubMed: | A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression. |
| PubMed: | Mechanism of catechin chemiluminescence in the presence of active oxygen. |
| PubMed: | Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. |
| PubMed: | Plant polyphenols: free radical scavengers or chain-breaking antioxidants? |
| PubMed: | [Relationship between the anti-hemolysin activity and the structure of catechins and theaflavins]. |
| PubMed: | Detection and chemical identification of natural bio-antimutagens. A case of the green tea factor. |
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