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Category: toxic natural substances
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 538.59 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 387.00 °F. TCC ( 197.40 °C. ) (est)
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| logP (o/w): | -0.400 (est) |
| Soluble in: |
| | water, 4044 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 113 mg/kg Applied and Environmental Microbiology. Vol. 50, Pg. 1304, 1985.
oral-mouse LD50 34 mg/kg BLOOD: CHANGES IN SPLEEN
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER" Food and Chemical Toxicology. Vol. 25, Pg. 155, 1987.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | toxic natural substances |
| Recommendation for 15-acetyl deoxynivalenol usage levels up to: | | | not for fragrance use.
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| Recommendation for 15-acetyl deoxynivalenol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Deoxynivalenol in food and feed: occurrence and exposure View page or View pdf |
Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 3034750 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0088337966 |
| RTECS: | YD0155000 for cas# 88337-96-6 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 15- | acetyldeoxynivalenol | | | trichothec-9-en-8-one, 15-(acetyloxy)-12,13-epoxy-3,7-dihydroxy-, (3-a,7-a)- |
Articles:
| PubMed: | Biodegradation and biodetoxification of Fusarium mycotoxins by Sphaerodes mycoparasitica. |
| PubMed: | Identification and trichothecene genotypes of Fusarium graminearum species complex from wheat in Taiwan. |
| PubMed: | Multi-Mycotoxin Analysis in Durum Wheat Pasta by Liquid Chromatography Coupled to Quadrupole Orbitrap Mass Spectrometry. |
| PubMed: | Deoxynivalenol and Its Modified Forms: Are There Major Differences? |
| PubMed: | Multi-mycotoxin stable isotope dilution LC-MS/MS method for Fusarium toxins in beer. |
| PubMed: | Multi-mycotoxin contamination of couscous semolina commercialized in Morocco. |
| PubMed: | Endocrine activity of mycotoxins and mycotoxin mixtures. |
| PubMed: | Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells. |
| PubMed: | Protein engineering of Saccharomyces cerevisiae transporter Pdr5p identifies key residues that impact Fusarium mycotoxin export and resistance to inhibition. |
| PubMed: | Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products. |
| PubMed: | Effect of 4-week feeding of deoxynivalenol- or T-2-toxin-contaminated diet on lipid peroxidation and glutathione redox system in the hepatopancreas of common carp (Cyprinus carpio L.). |
| PubMed: | Transformation of deoxynivalenol and its acetylated derivatives in Chinese steamed bread making, as affected by pH, yeast, and steaming time. |
| PubMed: | Identification and Characterization of Carboxylesterases from Brachypodium distachyon Deacetylating Trichothecene Mycotoxins. |
| PubMed: | [Dietary exposure assessment of deoxynivalenol and its acetylate & derivatives in wheat flour in Shanghai]. |
| PubMed: | The Metabolic Fate of Deoxynivalenol and Its Acetylated Derivatives in a Wheat Suspension Culture: Identification and Detection of DON-15-O-Glucoside, 15-Acetyl-DON-3-O-Glucoside and 15-Acetyl-DON-3-Sulfate. |
| PubMed: | A method for simultaneous determination of 20 Fusarium toxins in cereals by high-resolution liquid chromatography-Orbitrap mass spectrometry with a pentafluorophenyl column. |
| PubMed: | Evaluation on levels and conversion profiles of DON, 3-ADON, and 15-ADON during bread making process. |
| PubMed: | Comparative assessment of three cleanup procedures after QuEChERS extraction for determination of trichothecenes (type A and type B) in processed cereal-based baby foods by GC-MS. |
| PubMed: | Cytotoxic effects and degradation products of three mycotoxins: alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in liver hepatocellular carcinoma cells. |
| PubMed: | Development and validation of an LC-MS/MS method for the toxicokinetic study of deoxynivalenol and its acetylated derivatives in chicken and pig plasma. |
| PubMed: | Mycotoxigenic potential of fungi isolated from freshly harvested Argentinean blueberries. |
| PubMed: | Fusarium species, chemotype characterisation and trichothecene contamination of durum and soft wheat in an area of central Italy. |
| PubMed: | Transcriptome profiling of wheat differentially expressed genes exposed to different chemotypes of Fusarium graminearum. |
| PubMed: | Evidence for a reversible drought induced shift in the species composition of mycotoxin producing Fusarium head blight pathogens isolated from symptomatic wheat heads. |
| PubMed: | Fitness attributes of Fusarium graminearum isolates from wheat in New York possessing a 3-ADON or 15-ADON trichothecene genotype. |
| PubMed: | Occurrence of Fusarium mycotoxins in Italian cereal and cereal products from organic farming. |
| PubMed: | Survey of 7 trichothecenes in corn-derived feed and feed ingredients. |
| PubMed: | Inter-laboratory study of an LC-MS/MS method for simultaneous determination of deoxynivalenol and its acetylated derivatives, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in wheat. |
| PubMed: | Simultaneous determination of masked deoxynivalenol and some important type B trichothecenes in Chinese corn kernels and corn-based products by ultra-performance liquid chromatography-tandem mass spectrometry. |
| PubMed: | Development of a purification method for simultaneous determination of deoxynivalenol and its acetylated and glycosylated derivatives in corn grits and corn flour by liquid chromatography-tandem mass spectrometry. |
| PubMed: | TRI12 based quantitative real-time PCR assays reveal the distribution of trichothecene genotypes of F. graminearum and F. culmorum isolates in Danish small grain cereals. |
| PubMed: | Heat- and cold-shock responses in Fusarium graminearum 3 acetyl- and 15 acetyl-deoxynivalenol chemotypes. |
| PubMed: | Population analysis of the Fusarium graminearum species complex from wheat in China show a shift to more aggressive isolates. |
| PubMed: | Chemotaxonomic diagnostics: combining sucrose-water agar with TLC to discriminate Fusarium graminearum 3-acetyl-DON and 15-acetyl-DON chemotypes. |
| PubMed: | Cross-reactivity of some commercially available deoxynivalenol (DON) and zearalenone (ZEN) immunoaffinity columns to DON- and ZEN-conjugated forms and metabolites. |
| PubMed: | Construction and characterization of a cDNA library from wheat infected with Fusarium graminearum Fg 2. |
| PubMed: | The 3ADON population of Fusarium graminearum found in North Dakota is more aggressive and produces a higher level of DON than the prevalent 15ADON population in spring wheat. |
| PubMed: | Effects of dietary Fusarium mycotoxins on intestinal lymphocyte subset populations, cell proliferation and histological changes in avian lymphoid organs. |
| PubMed: | Trichothecene chemotypes of Fusarium culmorum infecting wheat in Tunisia. |
| PubMed: | Quantification of Fusarium graminearum in harvested grain by real-time polymerase chain reaction to assess efficacies of fungicides on fusarium head blight, deoxynivalenol contamination, and yield of winter wheat. |
| PubMed: | Comparative mycotoxin profiles of Gibberella zeae populations from barley, wheat, potatoes, and sugar beets. |
| PubMed: | Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol. |
| PubMed: | LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs. |
| PubMed: | Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs. |
| PubMed: | Estimating mycotoxin contents of Fusarium-damaged winter wheat kernels. |
| PubMed: | Effects of feeding grains naturally contaminated with Fusarium mycotoxins on performance and metabolism of broiler breeders. |
| PubMed: | Multiplex PCR assay for the identification of nivalenol, 3- and 15-acetyl-deoxynivalenol chemotypes in Fusarium. |
| PubMed: | Simultaneous determination of type A-& B-trichothecenes and zearalenone in cereals by High Performance Liquid Chromatography - Tandem Mass Spectrometry. |
| PubMed: | [Determination of DON-3-Glucoside in artificially and naturally contaminated wheat with LC-MS/MS]. |
| PubMed: | Solvolysis procedures for the determination of bound residues of the mycotoxin deoxynivalenol in fusarium species infected grain of two winter wheat cultivars preinfected with barley yellow dwarf virus. |
| PubMed: | Incidence of trichothecenes and zearalenone in poultry feed mixtures from Slovakia. |
| PubMed: | Assessment of trichothecene chemotypes of Fusarium culmorum occurring in Europe. |
| PubMed: | DON calibrant: Towards the production of certified B-trichothecene calibrants. |
| PubMed: | Rapid simultaneous determination of major type A- and B-trichothecenes as well as zearalenone in maize by high performance liquid chromatography-tandem mass spectrometry. |
| PubMed: | Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. |
| PubMed: | Report from SCOOP task 3.2.10 "collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU member states". Subtask: trichothecenes. |
| PubMed: | Zearalenone in maize: stability testing and matrix characterisation of a certified reference material. |
| PubMed: | Rapid surface plasmon resonance-based inhibition assay of deoxynivalenol. |
| PubMed: | Detoxification of the Fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana. |
| PubMed: | Fast methods for screening of trichothecenes in fungal cultures using gas chromatography-tandem mass spectrometry. |
| PubMed: | Occurrence of trichothecenes in Argentinean beer: a preliminary exposure assessment. |
| PubMed: | A survey of Fusarium toxins in cereal-based foods marketed in an area of southwest Germany. |
| PubMed: | Natural occurrence of Fusarium toxins in oats harvested during five years in an area of southwest Germany. |
| PubMed: | Production of trichothecenes and zearalenone by isolates of Fusarium spp. from Argentinian maize. |
| PubMed: | Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994. |
| PubMed: | Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. |
| PubMed: | Cumulation of mycotoxins in maize cobs infected withFusarium gramihearum. |
| PubMed: | Natural occurrence of deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7-dideoxynivalenol, and zearalenone in polish wheat. |
| PubMed: | Mycotoxins and Fusarium spp. associated with infected ears of corn in Minnesota. |
| PubMed: | Natural occurrence and clastogenic effects of nivalenol, deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in corn from a high-risk area of esophageal cancer. |
| PubMed: | [Trichothecenes in staple food from a high-incidence area of carcinoma of the esophagus and gastric cardia and their carcinogenic potential]. |
| PubMed: | Natural occurrence of deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in refusal factor corn stored since 1972. |
| PubMed: | Deoxynivalenol and 15-monoacetyl deoxynivalenol production by Fusarium graminearum R6576 in liquid media. |
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