deoxynivalenol
vomitoxin
 
Notes:
Prod. by Fusarium graminearum and Fusarium roseum, responsible for headblight in cereals Vomitoxin, also known as deoxynivalenol (DON), is a type B trichothecene, an epoxy-sesquiterpeneoid. This mycotoxin occurs predominantly in grains such as wheat, barley, oats, rye, and maize, and less often in rice, sorghum, and triticale. The occurrence of deoxynivalenol is associated primarily with Fusarium graminearum (Gibberella zeae) and F. culmorum, both of which are important plant pathogens which cause Fusarium head blight in wheat and Gibberella ear rot in maize. A direct relationship between the incidence of Fusarium head blight and contamination of wheat with deoxynivalenol has been established. The incidence of Fusarium head blight is strongly associated with moisture at the time of flowering (anthesis), and the timing of rainfall, rather than the amount, is the most critical factor. Furthermore, deoxynivalenol contents are significantly affected by the susceptibility of cultivars towards Fusarium species, previous crop, tillage practices, and fungicide use
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
      Email: Marketing
      US Email: Marketing
      Email: Sales
      US Email: Sales
      Voice: 1-631-485-4226
      Fax: 1-631-614-7828
      US Voice: 1-631-485-4226
      US Fax: 1-631-614-7828
      Europe44-203-286-1088
      Facebook
      Twitter
      Linkedin
      Blog
      Get the App!
      Product(s):
      51481-10-8 Deoxynivalenol ≥98.0%
      Vomitoxin is a type B trichothecene, an epoxy-sesquiterpenoid. This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects. It inhibits protein biosynthesis, binds to peptidyl transferase, Potent protein synthesis inhibitor; Exhibits cytotoxic activity in vivo via the ribotoxic stress response;
       
       
Synonyms   Articles   Notes   Search
CAS Number: 51481-10-8Picture of molecule3D/inchi
Other(deleted CASRN): 115825-61-1
FDA UNII: JT37HYP23V
MDL: MFCD09039270
XlogP3-AA: -0.70 (est)
Molecular Weight: 296.31960000
Formula: C15 H20 O6
NMR Predictor: Predict (works with chrome or firefox)
Category: toxic natural substances
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 152.00 °C. @ 760.00 mm Hg
Boiling Point: 543.88 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 6.800000 mmHg (est)
Flash Point: 404.00 °F. TCC ( 206.90 °C. ) (est)
logP (o/w): -1.250 (est)
Soluble in:
 water, 5.175e+004 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
BOC Sciences
For experimental / research use only.
Deoxynivalenol ≥98.0%
Odor: characteristic
Use: Vomitoxin is a type B trichothecene, an epoxy-sesquiterpenoid. This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects. It inhibits protein biosynthesis, binds to peptidyl transferase, Potent protein synthesis inhibitor; Exhibits cytotoxic activity in vivo via the ribotoxic stress response;
Santa Cruz Biotechnology
For experimental / research use only.
Deoxynivalenol ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Deoxynivalenol
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-chicken LD50  140 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Poultry Science. Vol. 60, Pg. 1412, 1981.

intraperitoneal-mouse LD50  43 mg/kg
Toxicon. Vol. 24, Pg. 985, 1986.

oral-mouse LD50  46 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Fundamental and Applied Toxicology. Vol. 4, Pg. S124, 1984.

Dermal Toxicity:
subcutaneous-dog LD50 27 mg/kg
Veterinary and Human Toxicology. Vol. 25, Pg. 335, 1983.

subcutaneous-mouse LD50 45 mg/kg
Toxicon. Vol. 24, Pg. 985, 1986.

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: toxic natural substances
Recommendation for deoxynivalenol usage levels up to:
 not for fragrance use.
 
Recommendation for deoxynivalenol flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Authority (EFSA) reference(s):
Deoxynivalenol in food and feed: occurrence and exposure
View page or View pdf
Statement on the risks for public health related to a possible increase of the maximum level of deoxynivalenol for certain semi-processed cereal products
View page or View pdf
Evaluation of the increase of risk for public health related to a possible temporary derogation from the maximum level of deoxynivalenol, zearalenone and fumonisins for maize and maize products
View page or View pdf
The in vivo genotoxicity studies on nivalenol and deoxynivalenol
View page or View pdf
Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 442408
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0051481108
RTECS: YD0167000 for cas# 51481-10-8
Synonyms   Articles   Notes   Search   Top
References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 442408
Pubchem (sid): 135002057
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
KEGG (GenomeNet): C09747
HMDB (The Human Metabolome Database): HMDB36156
FooDB: FDB015009
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
 vomitoxin
Synonyms   Articles   Notes   Search   Top
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2021 Perflavory ™ Disclaimer Privacy Policy