|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 751.06 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 507.00 °F. TCC ( 264.10 °C. ) (est)
|
| logP (o/w): | 0.156 (est) |
| Soluble in: |
| | water, 4884 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for glycitin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for glycitin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 187808 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| Chemidplus: | 0040246104 |
References:
| | 3-(4-hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 187808 |
| Pubchem (sid): | 135166110 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4',7- | dihydroxy-6-methoxyisoflavone-7-D-glucoside | | 3-(4- | hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl b-D-glucopyranoside | | 3-(4- | hydroxyphenyl)-6-methoxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
Articles:
| PubMed: | Isoflavones of the Soybean Components and the Effect of Germination Time in the Cotyledons and Embryonic Axis. |
| PubMed: | Profile of the contents of different forms of soybean isoflavones and the effect of germination time on these compounds and the physical parameters in soybean sprouts. |
| PubMed: | Simultaneous Estimation of Glycosidic Isoflavones in Fermented and Unfermented Soybeans by TLC-Densitometric Method. |
| PubMed: | Identification and quantification of the main isoflavones and other phytochemicals in soy based nutraceutical products by liquid chromatography-orbitrap high resolution mass spectrometry. |
| PubMed: | Isoflavones profiling of soybean [Glycine max (L.) Merrill] germplasms and their correlations with metabolic pathways. |
| PubMed: | Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats. |
| PubMed: | Chemical compounds related to nutraceutical and industrial qualities of non-transgenic soybean genotypes. |
| PubMed: | Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation. |
| PubMed: | Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles. |
| PubMed: | Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression. |
| PubMed: | A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry. |
| PubMed: | Fast simultaneous determination of free and conjugated isoflavones in soy milk by UHPLC-UV. |
| PubMed: | Screening and identification of BSA bound ligands from Puerariae lobata flower by BSA functionalized Fe₃O₄ magnetic nanoparticles coupled with HPLC-MS/MS. |
| PubMed: | Hydrolysis of isoflavone glycosides by a thermostable β-glucosidase from Pyrococcus furiosus. |
| PubMed: | Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity. |
| PubMed: | NTP-CERHR expert panel report on the developmental toxicity of soy infant formula. |
| PubMed: | Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. |
| PubMed: | Characterization of a GH3 family β-glucosidase from Dictyoglomus turgidum and its application to the hydrolysis of isoflavone glycosides in spent coffee grounds. |
| PubMed: | Characterization of a β-glucosidase from Sulfolobus solfataricus for isoflavone glycosides. |
| PubMed: | UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. |
| PubMed: | Metabolism of Isoflavones Found in the Pueraria thomsonii Flower by Human Intestinal Microbiota. |
| PubMed: | A study of characteristic fragmentation of isoflavonoids by using negative ion ESI-MSn. |
| PubMed: | Optimizing time and temperature of enzymatic conversion of isoflavone glucosides to aglycones in soy germ flour. |
| PubMed: | Analysis of isoflavones and flavonoids in human urine by UHPLC. |
| PubMed: | Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. |
| PubMed: | Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression. |
| PubMed: | Hypolipidemic effects of Monascus-fermented soybean extracts in rats fed a high-fat and -cholesterol diet. |
| PubMed: | Soya isoflavone supplementation enhances spatial working memory in men. |
| PubMed: | Effects of a methanolic fraction of soybean seeds on the transcriptional activity of peroxisome proliferator-activated receptors (PPAR). |
| PubMed: | Effect of glycosidation of isoflavones on their bioavailability and pharmacokinetics in aged male rats. |
| PubMed: | [Isoflavone glycosides from the bark of Maackia amurensis]. |
| PubMed: | Stability of isoflavone isomers in steamed black soybeans and black soybean koji stored under different conditions. |
| PubMed: | Equol is more active than soy isoflavone itself to compete for binding to thromboxane A(2) receptor in human platelets. |
| PubMed: | Skim milk powder supplementation affects lactose utilization, microbial survival and biotransformation of isoflavone glycosides to isoflavone aglycones in soymilk by Lactobacillus. |
| PubMed: | Ultrahigh-pressure liquid chromatography of isoflavones and phenolic acids on different stationary phases. |
| PubMed: | Hydrolysis of isoflavone glucosides in soymilk fermented with single or mixed cultures of Lactobacillus paraplantarum KM, Weissella sp. 33, and Enterococcus faecium 35 isolated from humans. |
| PubMed: | Enhanced bioavailability of soy isoflavones by complexation with beta-cyclodextrin in rats. |
| PubMed: | Conversion of isoflavone glucosides to aglycones in soymilk by fermentation with lactic acid bacteria. |
| PubMed: | Comparison of isoflavone concentrations in soybean (Glycine max (L.) Merrill) sprouts grown under two different light conditions. |
| PubMed: | Rapid-resolution HPLC with spectrometric detection for the determination and identification of isoflavones in soy preparations and plant extracts. |
| PubMed: | Solvent effects on extraction and HPLC analysis of soybean isoflavones and variations of isoflavone compositions as affected by crop season. |
| PubMed: | Anti-obesity activities of fermented soygerm isoflavones by Bifidobacterium breve. |
| PubMed: | Bioavailability of soy isoflavones in rats Part I: application of accurate methodology for studying the effects of gender and source of isoflavones. |
| PubMed: | Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase. |
| PubMed: | Biotransformation of common bean (Phaseolus vulgaris L.) flavonoid glycosides by bifidobacterium species from human intestinal origin. |
| PubMed: | Isolation of six isoflavones from Semen sojae praeparatum by preparative HPLC. |
| PubMed: | Isoflavone phytoestrogen degradation in fermented soymilk with selected beta-glucosidase producing L. acidophilus strains during storage at different temperatures. |
| PubMed: | Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats. |
| PubMed: | [Preparation of soybean isoflavone glucosides by reversed-phase high performance liquid chromatography]. |
| PubMed: | An accurate and reproducible method for the quantitative analysis of isoflavones and their metabolites in rat plasma using liquid chromatography/mass spectrometry combined with photodiode array detection. |
| PubMed: | Influence of the application of three different elicitors on soybean plants on the concentrations of several isoflavones in soybean seeds. |
| PubMed: | Method development and validation for isoflavones in soy germ pharmaceutical capsules using micellar electrokinetic chromatography. |
| PubMed: | Distribution profiles of isoflavone isomers in black bean kojis prepared with various filamentous fungi. |
| PubMed: | Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry. |
| PubMed: | Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. |
| PubMed: | Determination of isoflavones in soy bits by fast column high-performance liquid chromatography coupled with UV-visible diode-array detection. |
| PubMed: | Quantitative determination and structural characterization of isoflavones in nutrition supplements by liquid chromatography-mass spectrometry. |
| PubMed: | Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector. |
| PubMed: | Isoflavonoids in the Rutaceae family: 1. Fortunella obovata, Murraya paniculata and four Citrus species. |
| PubMed: | Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways. |
| PubMed: | Isoflavonoid accumulation in soybean hairy roots upon treatment with Fusarium solani. |
| PubMed: | Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma. |
| PubMed: | Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection. |
| PubMed: | Ultrasound-assisted extraction of soy isoflavones. |
| PubMed: | Determination of isoflavones in ready-to-feed soy-based infant formula. |
| PubMed: | Evaluation of a soybean product fujiflavone P40 as an antiosteoporotic agent in rats. |
| PubMed: | Isoflavone, glyphosate, and aminomethylphosphonic acid levels in seeds of glyphosate-treated, glyphosate-resistant soybean. |
| PubMed: | Stabilities of daidzin, glycitin, genistin, and generation of derivatives during heating. |
| PubMed: | Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. |
| PubMed: | Efficacy and safety of a phytoestrogen preparation derived from Glycine max (L.) Merr in climacteric symptomatology: a multicentric, open, prospective and non-randomized trial. |
| PubMed: | Isoflavone aglycon and glucoconjugate content of high- and low-soy U.K. foods used in nutritional studies. |
| PubMed: | Effects of naturally occurring isoflavones on prostaglandin E2 production. |
| PubMed: | Determination of isoflavones in soy and selected foods containing soy by extraction, saponification, and liquid chromatography: collaborative study. |
| PubMed: | Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. |
| PubMed: | Separation and purification of isoflavones from a crude soybean extract by high-speed counter-current chromatography. |
| PubMed: | [Daily intake of isoflavones based on the market basket method]. |
| PubMed: | Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. |
| PubMed: | Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. |
| PubMed: | Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake. |
| PubMed: | Quantification of isoflavones by capillary zone electrophoresis in soybean seeds: effects of variety and environment. |
| PubMed: | Soy isoflavone analysis: quality control and a new internal standard. |
|