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Category: flavoring agents, food additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 421.27 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 289.00 °F. TCC ( 142.90 °C. ) (est)
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| logP (o/w): | 4.515 (est) |
| Soluble in: |
| | water, 0.5314 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | flavoring agents, food additives |
| Recommendation for capsiate usage levels up to: | | | not for fragrance use.
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Safety References:
References:
| | (4-hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9839519 |
| Pubchem (sid): | 135331264 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4- | hydroxy-3-methoxybenzyl (6E)-8-methyl-6-nonenoate | | (4- | hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate | | 6- | nonenoic acid, 8-methyl-, (4-hydroxy-3-methoxyphenyl)methyl ester, (E)- |
Articles:
| PubMed: | A single intake of capsiate improves mechanical performance and bioenergetics efficiency in contracting mouse skeletal muscle. |
| PubMed: | Different TRPV1-mediated brain responses to intragastric infusion of capsaicin and capsiate. |
| PubMed: | Thermal taste and anti-aspiration drugs: a novel drug discovery against pneumonia. |
| PubMed: | Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. |
| PubMed: | Capsiate improves glucose metabolism by improving insulin sensitivity better than capsaicin in diabetic rats. |
| PubMed: | Stimulation of calcitonin gene-related peptide release through targeting capsaicin receptor: a potential strategy for gastric mucosal protection. |
| PubMed: | The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. |
| PubMed: | Beneficial effects of capsiate on ethanol-induced mucosal injury in rats are related to stimulation of calcitonin gene-related Peptide release. |
| PubMed: | Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. |
| PubMed: | Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice. |
| PubMed: | Studies on the metabolism and toxicology of emerging capsinoids. |
| PubMed: | Chemical and pharmacological aspects of capsaicin. |
| PubMed: | Capsinoids, non-pungent capsaicin analogs, reduce body fat accumulation without weight rebound unlike dietary restriction in mice. |
| PubMed: | Evaluation of the antioxidant activity of capsiate analogues in polar, nonpolar, and micellar media. |
| PubMed: | Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses. |
| PubMed: | Recent advances in the study on capsaicinoids and capsinoids. |
| PubMed: | One-procedure synthesis of capsiate from capsaicin by lipase-catalyzed dynamic transacylation. |
| PubMed: | Studies of the toxicological potential of capsinoids XIV: a 26-week gavage toxicity study of dihydrocapsiate in rats. |
| PubMed: | Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. |
| PubMed: | Studies of the toxicological potential of capsinoids, XII: pharmacokinetic study of capsinoid-containing CH-19 Sweet extract in rats. |
| PubMed: | Studies of the toxicological potential of capsinoids, XI: pharmacokinetic and tissue distribution study of 14C-dihydrocapsiate and metabolites in rats. |
| PubMed: | Application of Hansch's model to capsaicinoids and capsinoids: a study using the quantitative structure-activity relationship. A novel method for the synthesis of capsinoids. |
| PubMed: | Assessment of the biological similarity of three capsaicin analogs (Capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits. |
| PubMed: | Capsiate inhibits ultraviolet B-induced skin inflammation by inhibiting Src family kinases and epidermal growth factor receptor signaling. |
| PubMed: | Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia. |
| PubMed: | Capsiate administration results in an uncoupling protein-3 downregulation, an enhanced muscle oxidative capacity and a decreased abdominal fat content in vivo. |
| PubMed: | Effect of capsinoids on energy metabolism in human subjects. |
| PubMed: | Determination of capsinoids by HPLC-DAD in capsicum species. |
| PubMed: | Studies of the toxicological potential of capsinoids: IX. Teratology studies of dihydrocapsiate in rats and rabbits. |
| PubMed: | Studies of the toxicological potential of capsinoids: VIII. A 13-week toxicity study of commercial-grade dihydrocapsiate in rats. |
| PubMed: | Studies of the toxicological potential of capsinoids: VII. A 13-week toxicity study of dihydrocapsiate in rats. |
| PubMed: | Studies of the toxicological potential of capsinoids: VI. Single-dose toxicity study and micronucleus test of commercial-grade dihydrocapsiate. |
| PubMed: | Studies of the toxicological potential of capsinoids: V. Genotoxicity studies of dihydrocapsiate. |
| PubMed: | Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture. |
| PubMed: | Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. |
| PubMed: | Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers. |
| PubMed: | Enzymatic synthesis of capsaicin analogs and their effect on the T-type Ca2+ channels. |
| PubMed: | Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans. |
| PubMed: | Downregulation of uncoupling protein-3 in vivo is linked to changes in muscle mitochondrial energy metabolism as a result of capsiate administration. |
| PubMed: | Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. |
| PubMed: | Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA. |
| PubMed: | Effects of capsinoid on serum and liver lipids in hyperlipidemic rats. |
| PubMed: | Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. |
| PubMed: | Involvement of reactive oxygen species in capsaicinoid-induced apoptosis in transformed cells. |
| PubMed: | TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. |
| PubMed: | Non-pungent capsaicinoids from sweet pepper synthesis and evaluation of the chemopreventive and anticancer potential. |
| PubMed: | Antioxidant activity of capsinoids. |
| PubMed: | Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-kappaB activation and is a potent antiinflammatory compound in vivo. |
| PubMed: | Enzymatic synthesis of a capsinoid by the acylation of vanillyl alcohol with fatty acid derivatives catalyzed by lipases. |
| PubMed: | Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. |
| PubMed: | CH-19 sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate. |
| PubMed: | CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. |
| PubMed: | Nordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, capsicum annuum |
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