silybum marianum herb
st. mary's thistle herb
 
Notes:
None found
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Name: silybum marianum l. herb
CAS Number: 84604-20-6 
ECHA EC Number: 283-298-7
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Aromatic and Allied Chemicals
Milk Thristal (Silybum marianum)
Bristol Botanicals
Milk Thistle herb powder Carduus marianus
Bristol Botanicals
Milk Thistle herb Carduus marianus, Bulgaria
Vege Tech
O.C. Milk Thistle
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  681 mg/kg
Indian Journal of Experimental Biology. Vol. 22, Pg. 487, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for silybum marianum herb usage levels up to:
 not for fragrance use.
 
Recommendation for silybum marianum herb flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
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Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 silybum marianum l. herb
Chemidplus: 0084604206
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References:
 silybum marianum l. herb
Canada Domestic Sub. List: 84604-20-6
Pubchem (sid): 135252480
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Other Information:
MedlinePlusSupp: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 milk thistle herb
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Synonyms:
lady's thistle herb
ladys thistle herb
milk thistle herb
st. mary's thistle herb
st. marys thistle herb
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Articles:
PubMed: Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle).
PubMed: The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity.
PubMed: Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cells.
PubMed: A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.
PubMed: Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
PubMed: Phenotyping studies to assess the effects of phytopharmaceuticals on in vivo activity of main human cytochrome p450 enzymes.
PubMed: Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.
PubMed: Antidiabetic plants of Iran.
PubMed: Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes.
PubMed: Identification of novel pregnane X receptor activators from traditional Chinese medicines.
PubMed: Silibinin: a novel inhibitor of Aβ aggregation.
PubMed: Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities.
PubMed: Patented bioavailability enhancement techniques of silymarin.
PubMed: Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.
PubMed: Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.
PubMed: A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases.
PubMed: Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
PubMed: Complementary and alternative medicine use by patients chronically infected with hepatitis C virus.
PubMed: Clinical applications of Silybum marianum in oncology.
PubMed: Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.).
PubMed: Does Silybum marianum play a role in the treatment of chronic hepatitis C?
PubMed: Silymarin treatment of viral hepatitis: a systematic review.
PubMed: Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans.
PubMed: Herb-drug interactions: a literature review.
PubMed: In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.
PubMed: [Flavonoids: risks or therapeutic opportunities?].
PubMed: The clinical utility of milk thistle (Silybum marianum) in cirrhosis of the liver.
PubMed: Milk thistle and the treatment of hepatitis.
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