valeriana officinalis
valerian
 
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Wisconsin Invasive Non-native plant species
Category: information only not used for fragrances or flavors
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Mountain Valley Growers
Valeriana officinalis Valerian
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Safety Information:
 
Hazards identification
 
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GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
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Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Wisconsin Invasive Non-native plant species
Recommendation for valeriana officinalis usage levels up to:
 not for fragrance use.
 
Recommendation for valeriana officinalis flavor usage levels up to:
 not for flavor use.
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Safety References:
None found
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References:
None found
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
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Potential Uses:
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Occurrence (nature, food, other): note
 valerian
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Synonyms:
 valerian
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Articles:
PubMed: Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites.
PubMed: Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis).
PubMed: The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.
PubMed: Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial.
PubMed: Valerian: no evidence for clinically relevant interactions.
PubMed: Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled split-mouth study.
PubMed: The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats.
PubMed: Evaluation of tobacco (Nicotiana tabacum L. cv. Petit Havana SR1) hairy roots for the production of geraniol, the first committed step in terpenoid indole alkaloid pathway.
PubMed: Metabolic flux phenotype of tobacco hairy roots engineered for increased geraniol production.
PubMed: Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia.
PubMed: Phytotherapy against insomnia: extravagant claims or an alternative medicine?
PubMed: Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: similar activity but difference in subcellular localization.
PubMed: Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation.
PubMed: Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.
PubMed: Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial.
PubMed: Teratogenic risk perception and confidence in use of medicines in pairs of pregnant women and general practitioners based on patient information leaflets.
PubMed: Adverse effects of herbal medicines: an overview of systematic reviews.
PubMed: Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization.
PubMed: Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis.
PubMed: Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis.
PubMed: Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors.
PubMed: Acylated iridoids from the roots of Valeriana officinalis var. latifolia.
PubMed: Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis).
PubMed: Phenotyping studies to assess the effects of phytopharmaceuticals on in vivo activity of main human cytochrome p450 enzymes.
PubMed: Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus.
PubMed: Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations.
PubMed: Enhanced chromatographic fingerprinting of herb materials by multi-wavelength selection and chemometrics.
PubMed: Sesquiterpenoids and lignans from the roots of Valeriana officinalis L.
PubMed: Complementary and Alternative Drugs Use among Preoperative Patients: A Cross-Sectional Study in Italy.
PubMed: Three phases hollow fiber LPME combined with HPLC-UV for extraction, preconcentration and determination of valerenic acid in Valeriana officinalis.
PubMed: Volvalerelactones A and B, two new sesquiterpenoid lactones with an unprecedented skeleton from Valeriana officinalis var. latifolia.
PubMed: Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.
PubMed: Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats.
PubMed: The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5).
PubMed: [Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies].
PubMed: Evaluation of commercial essential oil samples on the growth of postharvest pathogen Monilinia fructicola (G. Winter) Honey.
PubMed: Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study.
PubMed: Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.
PubMed: Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.
PubMed: Composition of essential oils in subterranean organs of three species of Valeriana L.
PubMed: Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women.
PubMed: Chemical analysis and biological activity of the essential oils of two valerianaceous species from China: Nardostachys chinensis and Valeriana officinalis.
PubMed: Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia.
PubMed: Treating primary insomnia - the efficacy of valerian and hops.
PubMed: Patterns of self-medication with medicinal plants and related adverse events--a South American survey.
PubMed: Phytotherapeutics: an evaluation of the potential of 1000 plants.
PubMed: Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
PubMed: [Knowledge of perioperative risk associated with use of medicinal plants].
PubMed: [Detection of viral infection pathogens in medicinal plants grown in Ukraine].
PubMed: Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine.
PubMed: Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.
PubMed: Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L.
PubMed: [HPLC fingerprint of the antiarrhythmic fraction of Valeriana officinalis].
PubMed: Iridoids and sesquiterpenoids from the roots of Valeriana officinalis.
PubMed: Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam.
PubMed: Direct metabolic fingerprinting of commercial herbal tinctures by nuclear magnetic resonance spectroscopy and mass spectrometry.
PubMed: Pinoresinol-4,4'-di-O-beta-D-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts.
PubMed: In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents.
PubMed: Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.
PubMed: Total synthesis of valerenic acid, a potent GABAA receptor modulator.
PubMed: A feasibility study of valerian extract for sleep disturbance in person with arthritis.
PubMed: Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.).
PubMed: Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study.
PubMed: Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier.
PubMed: Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease.
PubMed: A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia.
PubMed: Analysis of the thrips fauna (Thysanoptera) on flowers of herbs.
PubMed: Ethnophytotherapeutical research in the high Molise region (Central-Southern Italy).
PubMed: [Studies on chemical constituents of Valeriana officinalis].
PubMed: Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation.
PubMed: Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties.
PubMed: Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid.
PubMed: Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.
PubMed: Valeriana officinalis does not alter the orofacial dyskinesia induced by haloperidol in rats: role of dopamine transporter.
PubMed: Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors.
PubMed: Biological and analytical characterization of two extracts from Valeriana officinalis.
PubMed: Identification of individual herbal drugs in tea mixtures using restriction analysis of ITS DNA and real-time PCR.
PubMed: Valerian for sleep: a systematic review and meta-analysis.
PubMed: Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors.
PubMed: NF-kappaB modulators from Valeriana officinalis.
PubMed: Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes.
PubMed: Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice.
PubMed: Authentication of Valeriana procera Kunth and comparative account of five Valeriana species.
PubMed: Health effects of exposure to herb dust in valerian growing farmers.
PubMed: Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress.
PubMed: New acylated clionasterol glycosides from Valeriana officinalis.
PubMed: Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort.
PubMed: Exposure to airborne microorganisms, dust and endotoxin during processing of valerian roots on farms.
PubMed: A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects.
PubMed: Genotoxicity and anti-genotoxicity of some traditional medicinal herbs.
PubMed: Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro.
PubMed: In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.
PubMed: Determination of metal content in valerian root phytopharmaceutical derivatives by atomic spectrometry.
PubMed: Monograph. Valeriana officinalis.
PubMed: Extraction of valerenic acids from valerian (Valeriana officinalis L.) rhizomes.
PubMed: In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4.
PubMed: The use of valerian in neuropsychiatry.
PubMed: Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers.
PubMed: Neuroprotective properties of Valeriana officinalis extracts.
PubMed: Effect of supplemental tryptophan, vitamin E, and a herbal product on responses by pigs to vibration.
PubMed: Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans.
PubMed: Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation.
PubMed: Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers.
PubMed: [Consumption of medicinal herbs in patients attending a gastroenterology outpatient clinic].
PubMed: [Effects of Valeriana officinalis var. latifolia on expression of transforming growth factor beta 1 in hypercholesterolemic rats].
PubMed: Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.
PubMed: Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
PubMed: Mitogenic and comitogenic activities of polysaccharides from some European herbaceous plants.
PubMed: A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health.
PubMed: Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.
PubMed: (-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.
PubMed: The importance of pharmacological synergy in psychoactive herbal medicines.
PubMed: Analysis of sesquiterpenes in Valeriana officinalis by capillary electrophoresis.
PubMed: Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia.
PubMed: Synergy and other interactions in phytomedicines.
PubMed: Ultrasound-assisted extraction of water-soluble polysaccharides from the roots of valerian (Valeriana officinalis L.).
PubMed: Pacifigorgianes and tamariscene as constituents of Frullania tamarisci and Valeriana officinalis.
PubMed: A1 adenosine receptors and their ligands: overview and recent developments.
PubMed: Towards the industrial production of medicinal tincture by ultrasound assisted extraction.
PubMed: Valeriana officinalis.
PubMed: Influence of fibre coating in headspace solid-phase microextraction-gas chromatographic analysis of aromatic and medicinal plants.
PubMed: [Interactions between herbal medicines and drugs].
PubMed: Valerian for insomnia: a systematic review of randomized clinical trials.
PubMed: Valerian: Valeriana officinalis.
PubMed: Herbal medications for common ailments in the elderly.
PubMed: Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release.
PubMed: The relevance of herbal treatments for psychiatric practice.
PubMed: Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system.
PubMed: Hypericum perforatum inhibits the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest virus system.
PubMed: Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines.
PubMed: [Isolation and receptor binding properties of alkaloids and lignans from Valeriana officialis L].
PubMed: Neurological stamp. Valeriana officinalis (garden heliotrope).
PubMed: In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain.
PubMed: [Clinical studies on the treatment of coronary heart disease with Valeriana officinalis var latifolia].
PubMed: Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier.
PubMed: Effects of a prolonged administration of valepotriates in rats on the mothers and their offspring.
PubMed: High-yield production of valepotriates by hairy root cultures of Valeriana officnalis L. var. sambucifolia Mikan.
PubMed: [Valeriana officinalis and Crataegus oxyacantha: toxicity from repeated administration and pharmacologic investigations].
PubMed: [Saliunca].
PubMed: Central nervous depressant activity of valerenic Acid in the mouse.
PubMed: Valepotriate content in different in vitro cultures of Valerianaceae and characterization of Valeriana officinalis L. callus during a growth period.
PubMed: Analysis of primary and secondary plant products in Valeriana officinalis callus during a growth cycle.
PubMed: [Der Einfluss von Valerenal und Valerensäuren aus Valeriana officinalis auf die Aktivität von Ratten und den Dopamin-Metabolismus im Rattengehirn.]
PubMed: Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man.
PubMed: [Effects of Valeriana officinalis L extract on cardiovascular system].
PubMed: Quantifying the effects of mild sedatives.
PubMed: [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].
PubMed: [Analytische und pharmakologische Aspekte des ätherischen Oles von Valeriana officinalis.]
PubMed: Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis.
PubMed: [Composition of the flavonoids of Valeriana officinalis from the Asiatic part of the USSR].
PubMed: [Chemical weed control in the cropping of medicinal plants. Part 1: Valerian (Valeriana officinalis L.) (author's transl)].
PubMed: [Contribution to the study of valerian alcaloids (Valeriana officinalis, L.): actinidine and naphthyridylmethylketone, a new alkaloid (author's transl)].
PubMed: [Flavonoid makeup of Valeriana officinalis from the southern and central provinces of the Ukraine].
PubMed: [Active substances in Valeriana officinalis L].
PubMed: New methods in the cultivation of Valeriana officinalis.
PubMed: [Biosynthesis of alkaloids, valtrates and volatile oils in the roots of Valeriana officinalis L. from radioactive precursors].
PubMed: [Permissible content of stalk residues in crude Valeriana officinalis].
PubMed: [Pharmacological studies on the constituents of crude drugs and plants. 1. Pharmacological actions of Valeriana officinalis Linńe var. latifolia Miquel].
PubMed: [Dependence of the valepotriate and essential oil content in Valeriana officinalis L.s.l. on various exogenous and endogenous factors].
PubMed: [Valeroside A--a glycoside from valerian (Valeriana officinalis L.)].
PubMed: Isolation, structure and synthesis of alkaloids from Valeriana officinalis L.
PubMed: [Tests of "industrial lyophilization" of medicinal plants. 3. Valeriana officinalis L. Influence of lyophilization on the quality of the drug].
PubMed: [Comparative ethnomedical study of Valeriana officinalis L].
PubMed: [Separation of alkaloids from the dried roots and rhizomes of Valeriana officinalis L].
PubMed: Pharmacological investigation of certain Valeriana officinalis L. extracts.
PubMed: Valeriana officinalis Linn., its polyploid forms and the structure of their rhizomes and roots.
PubMed: [Yields in Valeriana officinalis cultivation].
PubMed: [Method for differentiation of preparations of Centranthus ruber DC from Valeriana officinalis L; preliminary note].
PubMed: [Cultivation of Valeriana officinalis].
PubMed: [Studies on the quality and capacity of Valeriana officinalis].
PubMed: [Studies on the modification of output and quality in Valeriana officinalis by growth technic and habitat].
PubMed: [Experiments on fertilization of Atropa belladonna and Valeriana officinalis].
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