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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 475.61 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 467.00 °F. TCC ( 241.40 °C. ) (est)
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| logP (o/w): | 2.340 (est) |
| Soluble in: |
| | water, 1030 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for piperlongumine usage levels up to: | | | not for fragrance use.
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| Recommendation for piperlongumine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 637858 |
| Pubchem (sid): | 135231077 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2(1H)- | pyridinone, 5,6-dihydro-1-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)- | | 2(1H)- | pyridinone, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]- | | 1-[3-(3,4,5- | trimethoxy-phenyl)-acryloyl]-5,6-dihydro-1H-pyridin-2-one | | 1-[(2E)-3-(3,4,5- | trimethoxyphenyl)prop-2-enoyl]-1,5,6-trihydropyridin-2-one | | 1-[(E)-3-(3,4,5- | trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one | | 1-[(2E)-3-(3,4,5- | trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one |
Articles:
| PubMed: | Dealing Naturally with Stumbling Blocks on Highways and Byways of TRAIL Induced Signaling. |
| PubMed: | Piperlongumine-induced phosphatidylserine translocation in the erythrocyte membrane. |
| PubMed: | Impact of DNA repair pathways on the cytotoxicity of piperlongumine in chicken DT40 cell-lines. |
| PubMed: | Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer. |
| PubMed: | Piperlongumine inhibits the proliferation and survival of B-cell acute lymphoblastic leukemia cell lines irrespective of glucocorticoid resistance. |
| PubMed: | Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review). |
| PubMed: | Piperlongumine Chemosensitizes Tumor Cells through Interaction with Cysteine 179 of IκBα Kinase, Leading to Suppression of NF-κB-Regulated Gene Products. |
| PubMed: | Targeting antioxidants for cancer therapy. |
| PubMed: | Piperlongumine induces cell death through ROS-mediated CHOP activation and potentiates TRAIL-induced cell death in breast cancer cells. |
| PubMed: | Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathways. |
| PubMed: | Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents. |
| PubMed: | Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells. |
| PubMed: | Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells. |
| PubMed: | Anticancer principles from medicinal piper ( hú jiāo) plants. |
| PubMed: | Piperlongumine as a potential activator of AMP-activated protein kinase in HepG2 cells. |
| PubMed: | Piperlongumine alleviates lupus nephritis in MRL-Fas(lpr) mice by regulating the frequency of Th17 and regulatory T cells. |
| PubMed: | Radio-sensitization by Piper longumine of human breast adenoma MDA-MB-231 cells in vitro. |
| PubMed: | Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells. |
| PubMed: | Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. |
| PubMed: | Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities. |
| PubMed: | Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. |
| PubMed: | Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate. |
| PubMed: | Synthesis of piperlogs and analysis of their effects on cells. |
| PubMed: | Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cells. |
| PubMed: | Piperlongumine induces autophagy by targeting p38 signaling. |
| PubMed: | Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. |
| PubMed: | An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells. |
| PubMed: | Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation. |
| PubMed: | ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. |
| PubMed: | Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. |
| PubMed: | Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century. |
| PubMed: | Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. |
| PubMed: | Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. |
| PubMed: | Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. |
| PubMed: | Overview of the therapeutic potential of piplartine (piperlongumine). |
| PubMed: | Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro. |
| PubMed: | Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. |
| PubMed: | Quantitative microtiter fibronectin fibrillogenesis assay: use in high throughput screening for identification of inhibitor compounds. |
| PubMed: | Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. |
| PubMed: | Specific 5-hydroxylation of piperlongumine by Beauveria bassiana ATCC 7159. |
| PubMed: | A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. |
| PubMed: | Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. |
| PubMed: | Selective killing of cancer cells by a small molecule targeting the stress response to ROS. |
| PubMed: | Overview for various aspects of the health benefits of Piper longum linn. fruit. |
| PubMed: | Antiplatelet effects of piplartine, an alkamide isolated from Piper tuberculatum: possible involvement of cyclooxygenase blockade and antioxidant activity. |
| PubMed: | Antiplatelet activities of newly synthesized derivatives of piperlongumine. |
| PubMed: | Antiplatelet effects of acidamides isolated from the fruits of Piper longum L. |
| PubMed: | Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A(2) receptor antagonist. |
| PubMed: | Suppression of ochratoxin biosynthesis by naturally occurring alkaloids. |
| PubMed: | Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro. |
| PubMed: | A piperidine amide extracted from Piper longum L. fruit shows activity against Aedes aegypti mosquito larvae. |
| PubMed: | Alkaloids of Piper longum Linn. I. Structure and synthesis of piperlongumine and piperlonguminine. |
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