piper methysticum root
root of the kawa-kawa, piper methysticum, piperaceae
 
Notes:
None found
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Name: piper methysticum root
CAS Number: 84696-40-2 
ECHA EC Number: 283-648-9
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Vege Tech
O.C. Kava Kava
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for piper methysticum root usage levels up to:
 not for fragrance use.
 
Recommendation for piper methysticum root flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 piper methysticum root
Chemidplus: 0084696402
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References:
 piper methysticum root
Pubchem (sid): 135283770
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Other Information:
FDA Listing of Food Additive Status: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 kava root
Search Trop  Picture
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Synonyms:
actiphyte of kava kava root
 kava root
 kava-kava root
 root of the kawa-kawa, piper methysticum, piperaceae
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Articles:
PubMed: Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.
PubMed: Kavain analogues as potential analgesic agents.
PubMed: Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells.
PubMed: Kava: a comprehensive review of efficacy, safety, and psychopharmacology.
PubMed: Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.
PubMed: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
PubMed: Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.
PubMed: Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?
PubMed: Kava consumption and its health effects.
PubMed: Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.
PubMed: In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum).
PubMed: Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.
PubMed: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
PubMed: Analysis of plant extracts by NIRS: simultaneous determination of kavapyrones and water in dry extracts of Piper methysticum Forst.
PubMed: Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction.
PubMed: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
PubMed: Kava does not display metabolic toxicity in a homogeneous cellular assay.
PubMed: Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.
PubMed: Hepatitis induced by Kava (Piper methysticum rhizoma).
PubMed: Acute hepatitis induced by kava kava.
PubMed: Kavain attenuates vascular contractility through inhibition of calcium channels.
PubMed: Densitometric analysis of kawain in kava-kava root extracts.
PubMed: Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses.
PubMed: Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review.
PubMed: Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
PubMed: Inhibition of haloperidol-induced catalepsy in rats by root extracts from Piper methysticum F.
PubMed: [Treatment with Kava--the root to ocombat stress].
PubMed: Effects of (+/-)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats.
PubMed: Kava dermopathy.
PubMed: Identification by methane chemical ionization gas chromatography/mass spectrometry of the products obtained by steam distillation and aqueous acid extraction of commercial Piper methysticum.
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