ketoconazole, 65277-42-1

Articles:

PubMed:	Liver injury associated with ketoconazole: Review of the published evidence.
PubMed:	Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers.
PubMed:	Combined administration of antibiotics and direct oral anticoagulants: a renewed indication for laboratory monitoring?
PubMed:	Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.
PubMed:	Quantitative modelling to estimate the transfer of pharmaceuticals through the food production system.
PubMed:	Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies.
PubMed:	Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
PubMed:	Fungal toenail infections.
PubMed:	CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells.
PubMed:	Ketoconazole in Cushing's disease: is it worth a try?
PubMed:	Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections.
PubMed:	Alogliptin: A new dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus.
PubMed:	Implantation phaeohyphomycosis caused by a non-sporulating Chaetomium species.
PubMed:	In vitro predictability of drug-drug interaction likelihood of P-glycoprotein-mediated efflux of dabigatran etexilate based on [I]2/IC50 threshold.
PubMed:	Candidiasis (oropharyngeal).
PubMed:	T-2 toxin is hydroxylated by chicken CYP3A37.
PubMed:	Ketoconazole modulates the infectivity of Ichthyophonus sp. (Mesomycetozoa) in vivo in experimentally injected European sea bass.
PubMed:	Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives.
PubMed:	Predictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides.
PubMed:	Utility of a column-switching LC/MS/MS method in cytochrome P450 inhibition assays using human liver microsomes.
PubMed:	Clinical pharmacology of axitinib.
PubMed:	Skin conditions: common skin rashes in infants.
PubMed:	Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats.
PubMed:	Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells.
PubMed:	Uptake of oxytetracycline, sulfamethoxazole and ketoconazole from fertilised soils by plants.
PubMed:	Telaprevir: pharmacokinetics and drug interactions.
PubMed:	Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics.
PubMed:	[The new anticoagulants - their role in secondary prevention of thromboembolism after stroke].
PubMed:	Ascending single-dose study of the safety profile, tolerability, and pharmacokinetics of bosutinib coadministered with ketoconazole to healthy adult subjects.
PubMed:	A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds.
PubMed:	Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.
PubMed:	Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp. leaves and roots ethanolic extracts and conventional antifungals.
PubMed:	Comparison of three fluorescent CYP3A substrates in two vertebrate models: pig and Atlantic salmon.
PubMed:	Candidiasis (oropharyngeal).
PubMed:	Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
PubMed:	Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.
PubMed:	Enhancement of β-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae.
PubMed:	A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects.
PubMed:	Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant.
PubMed:	Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.
PubMed:	Fungal toenail infections.
PubMed:	Broadening horizons in medical management of prostate cancer.
PubMed:	Antimicrobial properties of Quercus ilex L. proanthocyanidin dimers and simple phenolics: evaluation of their synergistic activity with conventional antimicrobials and prediction of their pharmacokinetic profile.
PubMed:	Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors.
PubMed:	Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
PubMed:	Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic.
PubMed:	Laser phototherapy for Stevens-Johnson syndrome: a case report.
PubMed:	Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4.
PubMed:	Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation.
PubMed:	Bioequivalence study of two formulations of 100 mg capsule of itraconazole. Quantification by tandem mass spectrometry.
PubMed:	Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats.
PubMed:	A review of clinical pharmacokinetics and pharmacodynamics of galantamine, a reversible acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, in healthy subjects and patients.
PubMed:	Seborrhoeic dermatitis.
PubMed:	Prescriber compliance with black box warnings in older adult patients.
PubMed:	Justification for the use of Ocimum gratissimum L in herbal medicine and its interaction with disc antibiotics.
PubMed:	Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates.
PubMed:	Clinical pharmacokinetics and pharmacodynamics of solifenacin.
PubMed:	PCOS.
PubMed:	The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport.
PubMed:	Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power.
PubMed:	Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.
PubMed:	Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design.
PubMed:	The need for multiple doses of 400 mg ketoconazole as a precipitant inhibitor of a CYP3A substrate in an in vivo drug-drug interaction study.
PubMed:	Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study.
PubMed:	CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides.
PubMed:	Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions.
PubMed:	Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers.
PubMed:	Fungal toenail infections.
PubMed:	Endocrine-disrupting properties in vivo of widely used azole fungicides.
PubMed:	1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics.
PubMed:	Seborrhoeic dermatitis.
PubMed:	Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.
PubMed:	Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.
PubMed:	The H295R system for evaluation of endocrine-disrupting effects.
PubMed:	Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents.
PubMed:	Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects.
PubMed:	Clinical pharmacokinetics of ranolazine.
PubMed:	The clinical pharmacokinetics of darifenacin.
PubMed:	Secondary hormonal therapy for advanced prostate cancer.
PubMed:	Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections.
PubMed:	Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial.
PubMed:	pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model.
PubMed:	Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine.
PubMed:	Exposure-response relationships and drug interactions of sirolimus.
PubMed:	Population-based case-control study of oral ketoconazole treatment for birth outcomes.
PubMed:	Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium.
PubMed:	Effect of fruit juices on the oral bioavailability of fexofenadine in rats.
PubMed:	Clinical pharmacology of bosentan, a dual endothelin receptor antagonist.
PubMed:	Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia.
PubMed:	The systemic treatment of onychomycosis.
PubMed:	Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease.
PubMed:	CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats.
PubMed:	Comparative efficacies of oral ketoconazole and terbinafine for reducing Malassezia population sizes on the skin of Basset Hounds.
PubMed:	Desloratadine: A preclinical and clinical overview.
PubMed:	Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
PubMed:	Lopinavir/ritonavir: a review of its use in the management of HIV infection.
PubMed:	Determination of clotrimazole in mice plasma by capillary electrophoresis.
PubMed:	Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects.
PubMed:	Rabeprazole: pharmacokinetics and pharmacokinetic drug interactions.
PubMed:	Atopic dermatitis and fungi.
PubMed:	Application of modeling and simulation to integrate clinical pharmacology knowledge across a new drug application.
PubMed:	Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol.
PubMed:	Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo.
PubMed:	Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences.
PubMed:	Clinical pharmacokinetics of quetiapine: an atypical antipsychotic.
PubMed:	Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug.
PubMed:	Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats.
PubMed:	Desloratadine: A new, nonsedating, oral antihistamine.
PubMed:	The pharmacologic profile of desloratadine: a review.
PubMed:	Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression.
PubMed:	Oral griseofulvin remains the treatment of choice for tinea capitis in children.
PubMed:	Ketoconazole reduces low dose cocaine self-administration in rats.
PubMed:	Drug interactions with cisapride: clinical implications.
PubMed:	Cardiac effects of ebastine and other antihistamines in humans.
PubMed:	Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam.
PubMed:	Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans.
PubMed:	Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: relationship to the discriminative stimulus effects of cocaine.
PubMed:	Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents.
PubMed:	Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole.
PubMed:	Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver.
PubMed:	A neuroendocrine role in cocaine reinforcement.
PubMed:	Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.
PubMed:	Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin.
PubMed:	Update on the management of onychomycosis: highlights of the Third Annual International Summit on Cutaneous Antifungal Therapy.
PubMed:	Diagnosis and treatment of tinea versicolor.
PubMed:	Coprescription of terfenadine and erythromycin or ketaconazole: an assessment of potential harm.
PubMed:	How 'bout that ritonavir?
PubMed:	Post-antibiotic effect and post-expositional polyene antagonism of azole antifungal agents in Candida albicans: dependence on substance lipophilia.
PubMed:	Innovative treatment approaches for rheumatoid arthritis. Cyclosporin, leflunomide and nitrogen mustard.
PubMed:	Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice.
PubMed:	Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo
PubMed:	The systemic treatment of onychomycosis.
PubMed:	Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences.
PubMed:	Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.
PubMed:	Effect of cimetidine, probenecid, and ketoconazole on the distribution, biliary secretion, and metabolism of [3H]taxol in the Sprague-Dawley rat.
PubMed:	Pharmacokinetic optimisation of oral antifungal therapy.
PubMed:	Is QT interval prolongation harmful? A regulatory perspective.
PubMed:	A banner year for AIDS therapy.
PubMed:	Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers.
PubMed:	Resolution of generalized dermatophytosis without treatment in dogs.
PubMed:	Special drug communication teleconference. August 7, 1992.
PubMed:	Drug interactions: part II.
PubMed:	Is there a role for fluconazole in the treatment of vulvovaginal candidiasis?
PubMed:	Ketoconazole for treatment of dermatophytosis in cats.
PubMed:	Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis.
PubMed:	Impaired intestinal function in symptomatic HIV infection.
PubMed:	Azoles and AIDS.
PubMed:	Amphotericin-resistant aspergillus osteomyelitis controlled by itraconazole.
PubMed:	Diseases and drugs but not food decrease ketoconazole 'bioavailability'.
PubMed:	The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects.
PubMed:	[Prevention of bacterial infections after bone marrow graft by broad-spectrum oral antibiotics, absorbable (pefloxacin, penicillin) and non absorbable (cephalosporin, gentamycin, bacitracin)].
PubMed:	Effect of food and gastric acidity on absorption of orally administered ketoconazole.
PubMed:	Clinical pharmacokinetics of ketoconazole.
PubMed:	Effects of ketoconazole on cholesterol synthesis and precursor concentrations in the rat liver.
PubMed:	The influence of food on the pharmacokinetics of itraconazole in patients with superficial fungal infection.
PubMed:	Trichosporonosis in patients with neoplastic disease.
PubMed:	Pharmacologic review: a review of the literature of ketoconazole therapy in the treatment of tinea pedis and onychomycosis.
PubMed:	Hepatic injury associated with ketoconazole therapy. Analysis of 33 cases.
PubMed:	Influence of food on the pharmacokinetics of ketoconazole.
PubMed:	Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man.
PubMed:	Ketoconazole.
PubMed:	Prophylaxis of fungal infections in neutropenic cancer patients.
PubMed:	Hepatotoxic potential of ketoconazole under investigation.
PubMed:	Impairing effect of food on ketoconazole absorption.
PubMed:	Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients.