Articles:
vasorelax
Notes:
a group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. protamines contain very few kinds of amino acids. protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (from merck index, 11th ed; martindale, the extra pharmacopoeia, 30th ed, p692)
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| CAS Number: | 9009-65-8 | |
| FDA UNII: | 0DE9724IHC | |
| MDL: | MFCD00132091 | |
Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
skin conditioning |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Protamines, sulfates 95% |
| Maypro Industries |
| Protamine Sulfate |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Protamine Sulfate, meets USP testing specifications |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-guinea pig LD50 120 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. intravenous-guinea pig LD50 120 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. intravenous-man LDLo 2174 ug/kg/25M VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 211, 1988. intraperitoneal-mouse LD50 94 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. intravenous-mouse LD50 38 mg/kg Russian Pharmacology and Toxicology Vol. 38, Pg. 73, 1975. intraperitoneal-rat LD50 120 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. intravenous-rat LD50 75 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 374, 1967. | |
| Dermal Toxicity: | |
|
subcutaneous-guinea pig LD50 200 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. subcutaneous-mouse LD50 200 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. subcutaneous-rabbit LD50 200 mg/kg Drugs in Japan Vol. 6, Pg. 726, 1982. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | cosmetic ingredient for skin conditioning | ||
| Recommendation for protamine sulfate usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for protamine sulfate flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 9009-65-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| Chemidplus: | 0009009658 |
| RTECS: | VO9470000 for cas# 9009-65-8 |
References:
| Pubchem (sid): | 135354089 |
Other Information:
| HMDB (The Human Metabolome Database): | Search |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| protamine sulphate | |
| vasorelax |