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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 309.60 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point: | 311.00 °F. TCC ( 155.20 °C. ) (est)
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| logP (o/w): | -1.721 (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-child LDLo 260 mg/kg/3D-I BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: COMA
BEHAVIORAL: HEADACHE Lancet. Vol. 1, Pg. 895, 1967.
oral-man TDLo 150 mg/kg/5D GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: TREMOR
SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE JAMA, Journal of the American Medical Association. Vol. 161, Pg. 515, 1956.
intraperitoneal-mouse LD50 3548 mg/kg SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
BEHAVIORAL: EXCITEMENT Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985.
oral-mouse LD50 8500 mg/kg BEHAVIORAL: ATAXIA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Medicinal Chemistry. Vol. 6, Pg. 336, 1963.
intravenous-mouse LDLo 100 mg/kg Compilation of LD50 Values of New Drugs.
intravenous-rabbit LDLo 175 mg/kg Compilation of LD50 Values of New Drugs.
oral-rat LD50 11200 mg/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of Medicinal Chemistry. Vol. 6, Pg. 336, 1963.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for piperazine citrate usage levels up to: | | | not for fragrance use.
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| Recommendation for piperazine citrate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 144-29-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 114763 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| | 2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine |
| Chemidplus: | 0000144296 |
| RTECS: | TL3485000 for cas# 144-29-6 |
References:
| | 2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 114763 |
| Pubchem (sid): | 135071059 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | helmizin | | 2- | hydroxy-1,2,3-propanetricarboxylate piperazine | | 2- | hydroxypropane-1,2,3-tricarboxylic acid;piperazine | | | multifuge citrate | | | piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1) | | | piperazine citrate anhydrous | | | piperazine compound with citric acid | | | piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) | | | piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) | | | piperazine, citrate (3:2) |
Articles:
| PubMed: | Piperazine citrate induced myoclonus in a child. |
| PubMed: | Phytochemical, anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb. |
| PubMed: | Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves. |
| PubMed: | Determination of anthelmintic activity of the leaf and bark extract of tamarindus indica linn. |
| PubMed: | A comparative study of the anthelmintic potential of cleome viscosa L. And cleome burmanni w. And a. |
| PubMed: | Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss. |
| PubMed: | Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives. |
| PubMed: | Studies on the anthelmintic property of aminobenzylated mannich bases. |
| PubMed: | Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles. |
| PubMed: | Evaluation of Anthelmintic Activities of Aerial Parts of Cynodon dactylon Pers. |
| PubMed: | Impact of subchronic administration of piperazine citrate on the electrocardiogram of the rat. |
| PubMed: | Evaluation of Anthelmintic Activity of Pistia stratiotes Linn. |
| PubMed: | Hypokalemic paralysis following severe vomiting in a child with intestinal obstruction due to round worms. |
| PubMed: | Piperazine protects the rat heart against sudden cardiac death from barium chloride-induced ventricular fibrillation. |
| PubMed: | Anti-inflammatory and anthelmintic activities of Solanum khasianum Clarke. |
| PubMed: | Human infection with Moniliformis moniliformis (Bremser 1811) (Travassos 1915) in Iran: another case report after three decades. |
| PubMed: | Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs. |
| PubMed: | Evaluation of anthelmintic activity of nuts of Semecarpus anacardium. |
| PubMed: | In Vitro Anthelmintic Activity of Baliospermum montanum Muell. Arg roots. |
| PubMed: | Time course of effect of piperazine citrate on the electrocardiogram of the rat. |
| PubMed: | Anthelmintic activity of leaves of justicia beddomei. |
| PubMed: | First total synthesis and biological screening of hymenamide E. |
| PubMed: | Anthelmintic activity of aerial parts of melothria heterophylla lour. |
| PubMed: | Occupational asthma due to piperazine citrate. |
| PubMed: | Electrocardiographic profile of oral piperazine citrate in healthy volunteers. |
| PubMed: | EVALUATION OF ANTHELMINTIC ACTIVITIES OF AERIAL PARTS of Celsia coromandeliane Vahl AND Mollugo pentaphylla Linn. |
| PubMed: | Unusual cerebellar ataxia: "worm wobble" revisited. |
| PubMed: | Comparison of practical treatment methods to eradicate pinworm (Dentostomella translucida) infections from Mongolian gerbils (Meroines unguiculatus). |
| PubMed: | Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid. |
| PubMed: | Management of intestinal obstruction caused by ascariasis. |
| PubMed: | Piperazine neurotoxicity: worm wobble revisited. |
| PubMed: | Ultrasound in the diagnosis of roundworms in gallbladder and common bile duct. Report of four cases. |
| PubMed: | Significant changes in gastrointestinal tract parasitic infections in children of St. Kitts over the 9-year period 1982-1991. |
| PubMed: | Surgical manifestations of ascariasis in childhood. |
| PubMed: | [Ascariasis of the gallbladder. Report of 2 cases and review of the literature]. |
| PubMed: | Endogenous formation of N-nitrosamines from piperazine and their urinary excretion following antihelmintic treatment with piperazine citrate. |
| PubMed: | A field evaluation of anthelmintics for control of cyathostomes of horses in Brazil. |
| PubMed: | Mebendazole poisoning in infancy. |
| PubMed: | Prevalence, incidence, intensity and associated morbidity of intestinal helminths in south Thailand. |
| PubMed: | Experimental chemotherapy in horses infected with benzimidazole-resistant small strongyles. |
| PubMed: | Antibodies to diethylcarbamazine cross-react with microfilariae of Wuchereria bancrofti. |
| PubMed: | Some effects of piperazine citrate on skeletal muscle and central nervous system. |
| PubMed: | Piperazine toxicity in Afghan puppies. |
| PubMed: | A comparison of the genetic activity of pyrvinium pamoate with that of several other anthelmintic drugs in Saccharomyces cerevisiae. |
| PubMed: | Mortality of captive tortoises due to viviparous nematodes of the genus Proatractis (Family Atractidae). |
| PubMed: | Piperazine toxicity in a kitten. |
| PubMed: | Biliary ascariasis: ultrasonography, endoscopic retrograde cholangiopancreatography, and biliary drainage. |
| PubMed: | [Determination of piperazine in hen eggs with HPLC following oral administration]. |
| PubMed: | Effect of Ascaris lumbricoides on zinc level in blood and urine. |
| PubMed: | Treatment of helminthic diseases. |
| PubMed: | Intestinal nematode infections. |
| PubMed: | Comparative antiarrhythmic and local anaesthetic effects of piperazine citrate and lignocaine hydrochloride. |
| PubMed: | Evaluation of febantel used concurrently with piperazine citrate in horses. |
| PubMed: | A comparative evaluation of mebendazole, piperazine and pyrantel in threadworm infection. Anthelmintic Study Group on Enterobiasis. |
| PubMed: | Effects of piperazine citrate and of the anti-Ascaris fraction of the ethanolic extract of the bark of Polyadoa umbellata (erin) on mammalian non-vascular smooth muscle. |
| PubMed: | Electrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle. |
| PubMed: | Prevention of the platelet alpha-granule release reaction by membrane-active drugs. |
| PubMed: | Single dose piperazine therapy for Ascaris lumbricoides: an unsuccessful method of promoting growth. |
| PubMed: | Hypocalcemic tetany induced by piperazine citrate in a mountain lion. |
| PubMed: | Erythema annulare centrifugum associated with ascariasis. |
| PubMed: | Controlled comparative study of the efficacy of pyrantel pamoate and a combined regimen of piperazine citrate and bephenium hydroxynaphthoate in the treatment of intestinal nemathelminthiases. |
| PubMed: | Piperazine toxicity in a new born. |
| PubMed: | Treatment of Syphacia obvelata in the Syrian hamster (Mesocricetus auratus) with piperazine citrate. |
| PubMed: | Absorption of macronutrients from a rice-vegetable diet before and after treatment of ascariasis in children. |
| PubMed: | Ascariasis and malnutrition. A study in urban Ethiopian children. |
| PubMed: | Eradication of the pinworm Syphacia obvelata from an animal unit by anthelmintic therapy. |
| PubMed: | Ethylenediamine sensitivity with a systemic reaction to piperazine citrate. |
| PubMed: | [Frequency of vulvovaginitis in girls with intestinal enterobiasis]. |
| PubMed: | An evaluation of levamisole for treatment of ascariasis. |
| PubMed: | Control of ascariasis by mass treatment with piperazine citrate. |
| PubMed: | Ascaris lumbricoides--a reminder. |
| PubMed: | Treatment of intestinal parasitic disease. |
| PubMed: | Quantitative determination of piperazine citrate in piperazine citrate syrup USP. |
| PubMed: | Human urinary excretion of piperazine citrate from syrup formulations. |
| PubMed: | Pyrantel pamoate in roundworm infestations: a comparative trial with piperazine citrate given in a single dose. |
| PubMed: | Levamisole in the treatment of ascariasis in children. |
| PubMed: | [The result of a single treatment with piperazine citrate in endemic infestation of Ascaris lumbricoides in Usambara, Tanzania]. |
| PubMed: | Comparative efficacy of levo-tetramisole, parbendazole, and piperazine citrate against some common helminths of turkeys. |
| PubMed: | Evaluation of the efficacy of methyridine, piperazine citrate and a worm pill for the elimination of Ascaridia galli infection in fowls in intensive confined system. |
| PubMed: | Obliquely striated muscle. 3. Contraction mechanism of Ascaris body muscle. |
| PubMed: | Single-dose treatment for Ascaris infection with piperazine citrate; with a study of the egg-parasite ratio. |
| PubMed: | Possible precipitation of petit mal seizures with piperazine citrate. |
| PubMed: | Some aspects of the pharmacology of piperazine citrate (Antepar) and of the anti-ascaris fraction of the ethanolic extract of the bark of the erin tree (Polyadoa umbellata-Dalziel). |
| PubMed: | A study of the efficacy of thiabendazole and dithiazanine iodide-piperazine citrate suspension against intestinal parasites in the Macaca mulatta. |
| PubMed: | [COLORIMETRIC DETERMINATION OF HETRAZAN, PIPERAZINE CITRATE, AND THEIR PREPARATIONS]. |
| PubMed: | [Results of the treatment of oxyuriasis with Adipinian and piperazine citrate in children's homes in Gdansk and Sopot]. |
| PubMed: | Effect of diethylcarbamazine, oxophenarsine hydrochloride and piperazine citrate on toxocara canis larvae in mice. |
| PubMed: | An evaluation of piperazine citrate for preventing prenatal infections with the common dog ascarid (Toxocara canis). |
| PubMed: | Two case histories of serum sickness-like reaction following piperazine citrate (antepar). |
| PubMed: | An acute urticarial reaction to piperazine citrate. |
| PubMed: | Efficacy of piperazine citrate in removing worms from the alimentary canal of cattle. |
| PubMed: | [Piperazine citrate in ascariasis associated with typhoid fever]. |
| PubMed: | On the single-dose treatment of ascariasis with piperazine citrate. |
| PubMed: | [Piperazine citrate in the management of ascariasis]. |
| PubMed: | Mass treatment of ascariasis with a single dose of piperazine citrate. |
| PubMed: | Preliminary studies on the anthelmintic properties of piperazine citrate in dogs. |
| PubMed: | The effectiveness of piperazine citrate against intestinal helminths of the cat and dog. |
| PubMed: | Treatment of multiple intestinal worm infections with piperazine citrate. |
| PubMed: | [Piperazine citrate for treatment of oxyuriasis]. |
| PubMed: | [Piperazine citrate and hexylresorcinol therapy of ascariasis; study of 157 cases]. |
| PubMed: | Treatment of ascariasis in children with a single dose of piperazine citrate. |
| PubMed: | Comparison of two regimes for the treatment of enterobiasis with piperazine citrate. |
| PubMed: | [Infections by Ascaris lumbricoides in children treated with piperazine citrate]. |
| PubMed: | Oxyuriasis: incidence in two socioeconomic groups of negro children; use of piperazine citrate in therapy. |
| PubMed: | [Anthelmintic effect of piperazine citrate on oxyria and ascarides]. |
| PubMed: | Anaphylactogenic properties of piperazine citrate. |
| PubMed: | The treatment of cases of ascariasis with piperazine citrate with observations of the effect of the drug on other helminthiases. |
| PubMed: | Treatment of roundworm with piperazine citrate: antepar. |
| PubMed: | Treatment of Ascaris lumbricoides infections with piperazine citrate. |
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