tetronasin
tetronasinum
 
Notes:
Isol. from Streptomyces longisporoflavus. Investigated as ruminant feed additive
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CAS Number: 75139-06-9Picture of molecule3D/inchi
FDA UNII: BZ5N591H97
XlogP3-AA: 6.80 (est)
Molecular Weight: 602.80898000
Formula: C35 H54 O8
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Category: pharmaceuticals / chemical synthisis
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 690.68 °C. @ 760.00 mm Hg (est)
Flash Point: 406.00 °F. TCC ( 207.60 °C. ) (est)
logP (o/w): 3.603 (est)
Soluble in:
 water, 0.004066 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for tetronasin usage levels up to:
 not for fragrance use.
 
Recommendation for tetronasin flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
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EPI System: View
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 54719264
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0075139069
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 54719264
Pubchem (sid): 135030598
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): HMDB33494
FooDB: FDB011545
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 tetronasina
 tetronasinum
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Articles:
PubMed: Potentiation by metal ions of the efficacy of the ionophores, monensin and tetronasin, towards four species of ruminal bacteria.
PubMed: Fragmentation studies on tetronasin by accurate-mass electrospray tandem mass spectrometry.
PubMed: The effect of ruthenium(III) chloride on the formation of protonated parent ions in electrospray mass spectrometry.
PubMed: Effect of nigericin, monensin, and tetronasin on biohydrogenation in continuous flow-through ruminal fermenters.
PubMed: An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.
PubMed: Synthesis and chemistry of the ionophore antibiotic tetronasin.
PubMed: Cleavage of di- and tripeptides by Prevotella ruminicola.
PubMed: Polyethers.
PubMed: An ABC-transporter from Streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin.
PubMed: Induction of spermidine/spermine N1-acetyltransferase in human breast carcinoma cells. A possible role for calcium.
PubMed: The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen.
PubMed: Analysis of a gene cluster from S. longisporoflavus potentially involved in tetronasin biosynthesis.
PubMed: Fungistatic and fungicidal effects of the ionophores monensin and tetronasin on the rumen fungus Neocallimastix sp. LM1.
PubMed: Properties of ionophore-resistant Bacteroides ruminicola enriched by cultivation in the presence of tetronasin.
PubMed: Effect of supplemental lysocellin and tetronasin on growth, ruminal and blood metabolites, and ruminal proteolytic activity in steers grazing ryegrass.
PubMed: Effects of the ionophore tetronasin on nitrogen metabolism by ruminal microorganisms in vitro.
PubMed: Dose-response relationship of tetronasin administered to grazing steers.
PubMed: Effects of the ionophores monensin and tetronasin on simulated development of ruminal lactic acidosis in vitro.
PubMed: Dose-response relationship of the ionophore tetronasin in growing-finishing cattle.
PubMed: Effect of the novel ionophore tetronasin (ICI 139603) on ruminal microorganisms.
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