lysocellin
 
Notes:
polyether antibiotic.
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CAS Number: 55898-33-4Picture of molecule3D/inchi
XlogP3-AA: 4.80 (est)
Molecular Weight: 628.84420000
Formula: C34 H60 O10
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Category: pharmaceuticals / chemical synthisis
 
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Physical Properties:
Appearance: colorless crystalline solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 722.82 °C. @ 760.00 mm Hg (est)
Flash Point: 421.00 °F. TCC ( 216.00 °C. ) (est)
logP (o/w): 4.592 (est)
Soluble in:
 water, 0.007706 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  65 mg/kg
"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 3, Pg. 47, 1978.

oral-mouse LD50  350 mg/kg
"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 3, Pg. 47, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for lysocellin usage levels up to:
 not for fragrance use.
 
Recommendation for lysocellin flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf
EPI System: View
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3036964
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0055898334
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 3036964
Pubchem (sid): 135256366
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 lysocellin
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Articles:
Google Patents: Process to produce lysocellin
PubMed: Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide.
PubMed: Isolation and characterization of four polyether antibiotics, X-14889A, B, C, and D, closely related to lysocellin and the ferensimycins.
PubMed: Three novel polyether antibiotics X-14889A, C, and D from a streptomycete. Taxonomy of the producing organism, fermentation production and biological properties of the antibiotics.
PubMed: Circumvention of multidrug resistance in human carcinoma KB cells by polyether antibiotics.
PubMed: In vitro effects of the ionophore lysocellin on ruminal fermentation and microbial populations.
PubMed: Effect of supplemental lysocellin and tetronasin on growth, ruminal and blood metabolites, and ruminal proteolytic activity in steers grazing ryegrass.
PubMed: Effects of lysocellin and calcium level on mineral metabolism, performance and ruminal and plasma characteristics of beef steers.
PubMed: The effects of lysocellin and varying calcium levels on performance and ruminal and plasma characteristics of growing beef steers fed corn silage.
PubMed: Influence of lysocellin and monensin on mineral metabolism of steers fed forage-based diets.
PubMed: Lysocellin effects on growth performance, ruminal fermentation, nutrient digestibility and nitrogen metabolism in steers fed forage diets.
PubMed: In vitro study of the effect of different ionophore antibiotics and of certain derivatives on rumen fermentation and on protein nitrogen degradation.
PubMed: Effects of lysocellin on performance, ruminal and plasma characteristics of growing cattle.
PubMed: Isolation and characterization of three novel polyether antibiotics and three novel actinomycins as cometabolites of the same Streptomyces sp. X-14873, ATCC 31679.
PubMed: Ferensimycins A and B. Two polyether antibiotics. Taxonomy, fermentation, isolation, characterization and structural studies.
PubMed: Ca2+ ionophores and the activation of human blood platelets. The effects of ionomycin, beauvericin, lysocellin, virginiamycin S, lasalocid-derivatives and McN 4308.
PubMed: Studies on the ionophorous antibiotics. XVI. The ionophore-mediated calcium transport and concomitant osmotic swelling of mitochondria.
PubMed: The complete assignment of the 13C NMR spectra of lasalocid and the sodium salt-complex of the antibiotic.
PubMed: Studies on the ionophorous antibiotics. XI. The artifacts and the degradation products of lysocellin.
PubMed: Studies on the ionophorous antibiotics. XII. Effects of ionophore lysocellin on cation distribution and respiration in mitochondria.
PubMed: Studies on the ionophorous antibiotics. VIII. Effects of monovalent and divalent cation ionophores on blood platelets.
PubMed: Studies on ionophorous antibiotics VII. A broad cation selective ionophore, lysocellin.
PubMed: Lysocellin, a new polyether antibiotic. I. Isolation, purification, physico-chemical and biological properties.
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