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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for gymnemic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for gymnemic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
Articles:
| PubMed: | Abiotic elicitation of gymnemic acid in the suspension cultures of Gymnema sylvestre. |
| PubMed: | Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar). |
| PubMed: | [Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult]. |
| PubMed: | In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br. |
| PubMed: | A systematic review of Gymnema sylvestre in obesity and diabetes management. |
| PubMed: | Gymnemic acids inhibit hyphal growth and virulence in Candida albicans. |
| PubMed: | Effect of a deacyl gymnemic acid on glucose homeostasis & metabolic parameters in a rat model of metabolic syndrome. |
| PubMed: | Abiotic elicitation of gymnemic acid in the suspension cultures of Gymnema sylvestre. |
| PubMed: | Anti-apoptotic potential of gymnemic acid phospholipid complex pretreatment in Wistar rats with experimental cardiomyopathy. |
| PubMed: | Production of gymnemic acid depends on medium, explants, PGRs, color lights, temperature, photoperiod, and sucrose sources in batch culture of Gymnema sylvestre. |
| PubMed: | Protective effect of herbomineral formulation (Dolabi) on early diabetic nephropathy in streptozotocin-induced diabetic rats. |
| PubMed: | Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar). |
| PubMed: | In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats. |
| PubMed: | A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. |
| PubMed: | In vitro production of gymnemic acid from Gymnema sylvestre (Retz) R. Br. ex roemer and schultes through callus culture under abiotic stress conditions. |
| PubMed: | Gymnemic acid interacts with mammalian glycerol-3-phosphate dehydrogenase. |
| PubMed: | Extraction and quantification of gymnemic acids through gymnemagenin from callus cultures of Gymnema sylvestre. |
| PubMed: | Standardisation of Gymnema sylvestre R.Br. by high-performance thin-layer chromatography: an improved method. |
| PubMed: | Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal. |
| PubMed: | Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions. |
| PubMed: | Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. |
| PubMed: | Interaction of gymnemic acid with cyclodextrins analyzed by isothermal titration calorimetry, NMR and dynamic light scattering. |
| PubMed: | [Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult]. |
| PubMed: | An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. |
| PubMed: | Inhibitory effect of voglibose and gymnemic acid on maltose absorption in vivo. |
| PubMed: | Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestine. |
| PubMed: | Caloric restriction in primates and relevance to humans. |
| PubMed: | Structure-activity relationships of triterpenoid derivatives extracted from Gymnema inodorum leaves on glucose absorption. |
| PubMed: | Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. |
| PubMed: | Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. |
| PubMed: | Taste confusions following gymnemic acid rinse. |
| PubMed: | Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves. |
| PubMed: | Inhibitory effect of gymnemic acid on intestinal absorption of oleic acid in rats. |
| PubMed: | Taste in chimpanzees. III: Labeled-line coding in sweet taste. |
| PubMed: | Influence of sweet suppressing agent on gustatory brain evoked potentials generated by taste stimuli. |
| PubMed: | Sweet and sweetness-inducing activities of new triterpene glycosides, strogins. |
| PubMed: | Medicinal foodstuffs. X. Structures of new triterpene glycosides, gymnemosides-c, -d, -e, and -f, from the leaves of Gymnema sylvestre R. Br.: influence of gymnema glycosides on glucose uptake in rat small intestinal fragments. |
| PubMed: | Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b. |
| PubMed: | Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre leaves. |
| PubMed: | Taste in chimpanzee: I. The summated response to sweeteners and the effect of gymnemic acid. |
| PubMed: | New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre. |
| PubMed: | An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats. |
| PubMed: | Isolation and structure elucidation of gymnemic acids, antisweet principles of Gymnema sylvestre. |
| PubMed: | Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins. |
| PubMed: | On the taste of umami in chimpanzee. |
| PubMed: | Binding proteins for sweet compounds from gustatory papillae of the cow, pig and rat. |
| PubMed: | Effects of gymnemic acid on the chorda tympani proper nerve responses to sweet, sour, salty and bitter taste stimuli in the chimpanzee. |
| PubMed: | Sweet taste receptor mechanisms. |
| PubMed: | Studies on snake venom enzymes: Part II--Partial characterization of ATPases from Russell's viper (Vipera russelli) venom & their interaction with potassium gymnemate. |
| PubMed: | Studies on snake venom enzymes: Part I. Purification of ATPase, a toxic component of Naja naja venom & its inhibition by potassium gymnemate. |
| PubMed: | Time-dependent inhibition of sucrose sweetness with gymnemic acid: mode of action. |
| PubMed: | On the effects of gymnemic acid in the hamster and rat. |
| PubMed: | Sweetening agents from natural sources. |
| PubMed: | Effect of gymnemic acid on single taste hairs of the housefly, Musca domestica. |
| PubMed: | [Physiology of smell and taste]. |
| PubMed: | Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on the isolation and heterogeneity of gymnemic acid A1. |
| PubMed: | Inhibition of ATPases by gymnemic acid. |
| PubMed: | Reduction of sucrose preference in the hamster by gymnemic acid. |
| PubMed: | Biological effects of Gymnema sylvestre fractions. II. Electrophysiology--effect of gymnemic acid on taste receptor response. |
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