salvia miltiorrhiza flower/leaf/root extract
extract of the roots, flowers and leaves of the chinese sage, salvia miltiorrhiza, lamiaceae
 
Notes:
a plant species which is known as an oriental traditional medicinal plant.
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Name: salvia miltiorhiza flower/leaf/root extract
CAS Number: 90106-50-6 
ECHA EC Number: 290-273-4
Category: cosmetic ingredient for skin conditioning
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
Changsha Organic Herb
Dan-shen Extract
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for salvia miltiorrhiza flower/leaf/root extract usage levels up to:
 not for fragrance use.
 
Recommendation for salvia miltiorrhiza flower/leaf/root extract flavor usage levels up to:
 not for flavor use.
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Safety References:
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National Institute of Allergy and Infectious Diseases: Data
 salvia miltiorhiza flower/leaf/root extract
Chemidplus: 090106506
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References:
 salvia miltiorhiza flower/leaf/root extract
Canada Domestic Sub. List: 90106-50-6
Pubchem (sid): 135289603
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 sage red sage
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Synonyms:
 extract of the roots, flowers and leaves of the chinese sage, salvia miltiorrhiza, lamiaceae
chinese sage flower/leaf/root extract
 salvia miltiorhiza flower/leaf/root extract
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Articles:
PubMed: Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.
PubMed: Comprehensive multi-channel multi-dimensional counter-current chromatography for separation of tanshinones from Salvia miltiorrhiza Bunge.
PubMed: Salvia miltiorrhiza (Danshen) injection ameliorates iron overload-induced cardiac damage in mice.
PubMed: Danshen (Salvia miltiorrhiza) injection suppresses kidney injury induced by iron overload in mice.
PubMed: Aqueous extract of danshen (Salvia miltiorrhiza Bunge) protects ovariectomized rats fed with high-fat diet from endothelial dysfunction.
PubMed: Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
PubMed: Competitive inhibition of human organic anion transporters 1 (SLC22A6), 3 (SLC22A8) and 4 (SLC22A11) by major components of the medicinal herb Salvia miltiorrhiza (Danshen).
PubMed: Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats.
PubMed: Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials.
PubMed: Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages.
PubMed: Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats.
PubMed: [Effects of danshen injection on the proliferation of rheumatoid arthritis fibroblast-like synoviocytes cultured with human serum].
PubMed: Effects of the aqueous extract of Salvia Miltiorrhiza (danshen) and its magnesium tanshinoate B-enriched form on blood pressure.
PubMed: Optimization of liquid chromatographic method for the separation of nine hydrophilic and hydrophobic components in Salviae miltiorrhizae Radix et Rhizoma (Danshen) using microemulsion as eluent.
PubMed: Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion.
PubMed: Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen).
PubMed: Postmarketing safety evaluation: depside salt injection made from Danshen (Radix Salviae Miltiorrhizae).
PubMed: Molecular evidence of cryptotanshinone for treatment and prevention of human cancer.
PubMed: A simple and reliable method for distinguishing danshen in salvia: simultaneous quantification of six active compositions by HPLC.
PubMed: Danshen (Salvia miltiorrhiza) extract inhibits proliferation of breast cancer cells via modulation of Akt activity and p27 level.
PubMed: The role of traditional Chinese medicines in osteogenesis and angiogenesis.
PubMed: Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.
PubMed: Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats.
PubMed: [Study on "multi-dimensional structure and process dynamics quality control system" of Danshen infusion solution based on component structure theory].
PubMed: Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926 cells.
PubMed: [Determination of the allergic impurities in the parenteral injection of Chinese traditional medicines containing Salvia miltiorrhiza].
PubMed: Investigation of the absorbed and metabolized components of Danshen from Fuzheng Huayu recipe and study on the anti-hepatic fibrosis effects of these components.
PubMed: [Effects of danshen on NO and ET-1 secreted by endothelial cells induced by the serum of pre-eclampsia patients].
PubMed: [Experimental study on anti-atherosclerotic effect of compatibility of active components of danshen and shanzha].
PubMed: Monitoring batch-to-batch reproducibility using direct analysis in real time mass spectrometry and multivariate analysis: a case study on precipitation.
PubMed: [Experimental study on anaphylactoid reactions of guinea pig induced by danshen injection and its components].
PubMed: Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture.
PubMed: [Analysis on patent network of compound Danshen extracts built by Tasly].
PubMed: Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins.
PubMed: [Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits].
PubMed: [Effect of compound danshen dripping pill combined with intravenous transplantation of human umbilical cord blood mononuclear cells on local inflammatory response in the myocardium of rabbits with acute myocardial infarction].
PubMed: Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection.
PubMed: [Regulatory roles of compound danshen in the downstream path of cyclooxygenases in rheumatoid arthritis patients' synovium].
PubMed: [Meta-analysis on impact of Danshen on liver regeneration in rats].
PubMed: Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities.
PubMed: [Study on fingerprint chromatograms of water-soluble constituents of Salvia miltiorrhiza Bge. by high performance liquid chromatography].
PubMed: [Multistage multivariate statistic quality control (MMSQC) for monitoring production process of traditional Chinese medicines].
PubMed: Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts.
PubMed: Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia.
PubMed: Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.
PubMed: Chinese herbal medicine Danshen formulations for preventing renal disease in Henoch-Schönlein Purpura: a systematic review and meta-analysis.
PubMed: Quality by design for herbal drugs: a feedforward control strategy and an approach to define the acceptable ranges of critical quality attributes.
PubMed: Evaluation of cardiomyocyte hypoxia injury models for the pharmacological study in vitro.
PubMed: Effect of danshen on the zero-stress state of rat's abdominal aorta.
PubMed: A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment.
PubMed: A target analogue imprinted polymer for the recognition of antiplatelet active ingredients in Radix Salviae Miltiorrhizae by LC/MS/MS.
PubMed: Protective and antioxidant effect of Danshen polysaccharides on cerebral ischemia/reperfusion injury in rats.
PubMed: Enhanced antioxidant bioactivity of Salvia miltiorrhiza (Danshen) products prepared using nanotechnology.
PubMed: Direct vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization.
PubMed: Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCɛ/mK(ATP) pathway in rats.
PubMed: Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).
PubMed: Effects of the aqueous extract from Salvia miltiorrhiza Bge on the pharmacokinetics of diazepam and on liver microsomal cytochrome P450 enzyme activity in rats.
PubMed: [Medicinal plants in the phytotherapy of alcohol or nicotine addiction. Implication for plants in vitro cultures].
PubMed: Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways.
PubMed: Danshen diversity defeating dementia.
PubMed: [Effect of Salvia miltiorrhiza on the left ventricular diastolic function in coronary artery stenosis].
PubMed: [Experimental study on myocardial protection with verapamil and salvia miltiorrhiza Bunge cardioplegia].
PubMed: Magnetic screening of the potential targeted protein of salvianolic acid B using T7 phage display library.
PubMed: Interaction between warfarin and danshen (Salvia miltiorrhiza).
PubMed: [Effect of salvia miltiorrhiza composita on superoxide dismutase and malonyldialdehyde in treating patients with non-insulin dependent diabetes mellitus (NIDDM)].
PubMed: [Effect of Salvia miltiorrhiza on the cardial ischemia in rats induced by ligation].
PubMed: [Protective effects of nerve growth factor vs Danshen on hippocampal neuron against global ischemia-reperfusion injury in gerbils].
PubMed: [Prevention of radiation injury of the lungs by Salvia miltiorrhiza in mice].
PubMed: [Effects of Danshen injection on glial cell line-derived neurotrophic factor mRNA of acute spinal cord injury rats and its mechanisms].
PubMed: [Effects of different administration of Salvia miltiorrhiza and heparin on antithrombin IIIAg, antithrombin III: A and alpha 2-macroglobulin in patients with cor pulmonale].
PubMed: [Protective mechanism of Salvia miltiorrhiza and Paeonia lactiflora for experimental liver damage].
PubMed: [Protective action of Salvia miltiorrhiza aqueous extract on chemically induced acute myocardial ischemia in rats].
PubMed: The effects of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats.
PubMed: [Prevention and treatment of isoproterenol induced ventricular fibrillation in rats by aqueous extract of Salvia miltiorrhiza].
PubMed: [Effect of Salvia miltiorrhiza co. on angiotensin II and atrial natriuretic polypeptide in rabbits].
PubMed: Mechanism of protective effects of Danshen against iron overload-induced injury in mice.
PubMed: Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats.
PubMed: [Effect of compound danshen dripping pill on arterial intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus].
PubMed: Microsphere resin chromatography combined with microbial biotransformation for the separation and purification of salvianolic acid B in aqueous extract of roots of Salvia multiorrihza Bunge.
PubMed: [The protective effects of Salvia miltiorrhiza on the warm ischemic kidney: experimental study in animals].
PubMed: [Quality evaluation of cultivated Salvia miltiorrhiza Bge. in Chongming, a suburb of Shanghai].
PubMed: [Dilative effect of injection of radix Angelicae, Salvia miltiorrhiza and ligustrazin on the pulmonary vessels in rats].
PubMed: [Effect of Salvia miltiorrhiza on the survival time of a heart allograft in experimental animals].
PubMed: [Effect of Liqustrazini and Salvia miltiorrhiza on extracorporeal fibroblast culture].
PubMed: [Effect of ligustrazine and salvia miltiorrhiza on microcirculation in the hamster cheek pouch].
PubMed: [Effect of Salvia miltiorrhiza on mesenteric microcirculatory blood flow in the dog measured by the Doppler effect of laser light].
PubMed: [Effect of Salvia miltiorrhiza root on calcium deposition in experimental fracture healing].
PubMed: The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats.
PubMed: [Platelet aggregation inhibitors from Salvia miltiorrhiza Bunge].
PubMed: [Effect of Salvia miltiorrhiza on hyperfibrinogen in patients with malignant lymphoma].
PubMed: [Clinical and experimental study on the effect of Salvia miltiorrhiza on microcirculation and 2,3 diphosphoglyceric acid in patients with coronary heart disease].
PubMed: [Changes in plasma 6-keto-PGF1 alpha, TXB2 lipid peroxides in acute cerebral infarction patients and the effects of Salvia miltiorrhiza on these three indices].
PubMed: [Reversed phase HPLC determination of three components in Salvia miltiorrhiza injections].
PubMed: [Water soluble constituents from radix Salvia miltiorrhiza before and after slicing].
PubMed: [The structure of dan-shen spiroketallactone of dan-shen (Salvia miltiorrhiza Bunge)].
PubMed: [Pharmacology of Salvia miltiorrhiza].
PubMed: [Effect of Salvia miltiorrhiza on experimental hepatic regeneration].
PubMed: [The relationship between root growth and cryptotanshinone content of Salvia miltiorrhiza].
PubMed: [Studies on the chemical components of Dan-shen (Salvia miltiorrhiza Bunge) (author's transl)].
PubMed: Pharmacological studies on the sedative-hypnotic effect of Semen Ziziphi spinosae (Suanzaoren) and Radix et Rhizoma Salviae miltiorrhizae (Danshen) extracts and the synergistic effect of their combinations.
PubMed: The quality of randomized controlled trials on DanShen in the treatment of ischemic vascular disease.
PubMed: Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery.
PubMed: [Effect of the mixed liquor of danshen and magnesium sulfate injection on IgG and IgM in serum of rabbits with lumbar intervertebral disc herniation].
PubMed: Rapid and sensitive analysis of multiple bioactive constituents in Compound Danshen preparations using LC-ESI-TOF-MS.
PubMed: Long-term treatment with danshen-gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK(ATP) pathway in rats.
PubMed: The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero.
PubMed: Mechanisms of the relaxant effect of a danshen and gegen formulation on rat isolated cerebral basilar artery.
PubMed: Simultaneous determination of seven active components of Fufang Danshen tablet by high performance liquid chromatography.
PubMed: Pharmacokinetic study of salvianolic acid A in rat after intravenous administration of Danshen injection.
PubMed: Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis.
PubMed: Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis.
PubMed: Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC-ESI-MSn.
PubMed: [Effect of a compound Danshen preparation in preventing long-term gastric lipid emulsion administration-induced nonalcoholic steatohepatitis in rats].
PubMed: Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.
PubMed: Danshen (Chinese medicinal herb) preparations for acute myocardial infarction.
PubMed: [Clinical study of diabetic retinopathy treated by compound danshen dripping pills].
PubMed: Danshen prevents the occurrence of oxidative stress in the eye and aorta of diabetic rats without affecting the hyperglycemic state.
PubMed: Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers.
PubMed: Simultaneous determination of magnesium lithospermate B, rosmarinic acid, and lithospermic acid in beagle dog serum by liquid chromatography/tandem mass spectrometry.
PubMed: Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.
PubMed: [Effect of Danshen root compound on blood lipid and bone biomechanics in mice with hyperlipemia-induced osteoporosis].
PubMed: Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.
PubMed: Impaired protein binding of Chinese medicine DanShen in uremic sera and sera with hyperbilirubinemia: rapid assessment of total and free DanShen concentrations using the fluorescence polarization immunoassay for digoxin.
PubMed: Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.
PubMed: [Identification of Panax notoginseng and its preparations by LC/MS].
PubMed: [Stromal cells from human Wharton's jelly differentiate into neural cells].
PubMed: A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes.
PubMed: Immunomodulatory effects of yun zhi and danshen capsules in health subjects--a randomized, double-blind, placebo-controlled, crossover study.
PubMed: [Studies and preparations of fufang danshen granules].
PubMed: [Effects of Chinese materia medica in activating blood and stimulating menstrual flow on the endocrine function of ovary-uterus and its mechanisms].
PubMed: Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation.
PubMed: [Use of amphotericin B-cells to detect inhibitors of cellular cholesterol biosynthesis].
PubMed: [Identification of tanshinones with related compounds by high performance thin layer chromatography and mass spectrometric analysis].
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