breviscapine
scutellarein 7-b-D-glucuronide
 
Notes:
4'-scutellarin-7-glucuronide isolated from the herb erigeron breviscapus (asteraceae); new-breviscapine is a mixture of breviscapine with fe, mg, & ca salts.
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CAS Number: 116122-36-2Picture of molecule3D/inchi
FDA UNII: 16IGP0ML9A
Nikkaji Web: J94.485H
XlogP3-AA: 0.80 (est)
Molecular Weight: 462.36486000
Formula: C21 H18 O12
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 891.58 °C. @ 760.00 mm Hg (est)
Flash Point: 599.00 °F. TCC ( 314.90 °C. ) (est)
logP (o/w): 0.426 (est)
Soluble in:
 water, 7023 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Changsha Organic Herb
Erigeron breviscapus Extract
Coompo
For experimental / research use only.
Breviscapine from Plants ≥98%
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  1314 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 14, Pg. 33, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for breviscapine usage levels up to:
 not for fragrance use.
 
Recommendation for breviscapine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 185617
National Institute of Allergy and Infectious Diseases: Data
 (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Chemidplus: 0116122362
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References:
 (2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 185617
Pubchem (sid): 135164598
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 erigeron breviscapus
Search Trop  Picture
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Synonyms:
 breviscapin
(2S,3S,4S,5R,6S)-6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
 scutellarein 7-b-D-glucuronide
 scutellarin
 viminol R2
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Articles:
PubMed: [Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels].
PubMed: [Study on the extraction of breviscapine from Erigeron breviscapus with ultrasonic wave technology optimized by central composite design-response surface method].
PubMed: Improved oral bioavailability of breviscapine via a Pluronic P85-modified liposomal delivery system.
PubMed: Mixed polyethylene glycol-modified breviscapine-loaded solid lipid nanoparticles for improved brain bioavailability: preparation, characterization, and in vivo cerebral microdialysis evaluation in adult Sprague Dawley rats.
PubMed: Progress on the protective effect of compounds from natural medicines on cerebral ischemia.
PubMed: Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats.
PubMed: Breviscapine reduces acute lung injury induced by left heart ischemic reperfusion in rats by inhibiting the expression of ICAM-1 and IL-18.
PubMed: Solid dispersion tablets of breviscapine with polyvinylpyrrolidone K30 for improved dissolution and bioavailability to commercial breviscapine tablets in beagle dogs.
PubMed: Pharmacokinetic interaction between scutellarin and valsartan in rats.
PubMed: Development of ionic-complex-based nanostructured lipid carriers to improve the pharmacokinetic profiles of breviscapine.
PubMed: Superior renoprotective effects of the combination of breviscapine with enalapril and its mechanism in diabetic rats.
PubMed: [Evaluation of transdermal property in vitro of different breviscapine lipid carrier gels].
PubMed: [Protective effect of breviscapine on human hepatocytes under hypoxia/re-oxygenation and its possible mechanism].
PubMed: Lipid emulsion as a drug delivery system for breviscapine: formulation development and optimization.
PubMed: UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats.
PubMed: Breviscapine inhibits high glucose-induced proliferation and migration of cultured vascular smooth muscle cells of rats via suppressing the ERK1/2 MAPK signaling pathway.
PubMed: Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery.
PubMed: [Intestinal lymphatic transport of breviscapine orally administered in rat].
PubMed: Metabolic transformation of DMBA-induced carcinogenesis and inhibitory effect of salvianolic acid b and breviscapine treatment.
PubMed: Preparation, characterization and evaluation of breviscapine lipid emulsions coated with monooleate-PEG-COOH.
PubMed: [The anti-injury effect of breviscapine injection on the hypoxic ischemic brain damage of neonatal rats and the expression of Bcl-2 and Bax].
PubMed: [Study on the extraction of breviscapine from Erigeron breviscapus with ultrasonic wave technology optimized by central composite design-response surface method].
PubMed: Optimized preparation, characterization and biodistribution in heart of breviscapine lipid emulsion.
PubMed: Characterization, biodistribution and targeting evaluation of breviscapine lipid emulsions following intravenous injection in mice.
PubMed: [Formula screening and optimizing for the dispersible tablets of breviscapine by orthogonal experiment].
PubMed: [Protective effect of breviscapine on cardiac function in children after cardiopulmonary bypass undergoing open heart surgery].
PubMed: [Protective effects of Fufangdengzhanhua dripping pill on apoptosis induced by glutamate in cultured primary hippocampal neurons of rats].
PubMed: [Advances in studies on pharmacokinetics of scutellarin and scutellarein].
PubMed: Breviscapine protects against cardiac hypertrophy through blocking PKC-alpha-dependent signaling.
PubMed: Breviscapine-induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity.
PubMed: Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca(2+)-cycling proteins in streptozotocin-induced diabetic rats.
PubMed: Breviscapine improves functions of spatial learning and memory of focal cerebral ischemia rats.
PubMed: [Study on physicochemical properties and influence factors on stability of breviscapine].
PubMed: [Comparison of the distribution of breviscapine in the brain by different administration routes].
PubMed: Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway.
PubMed: Preparation, characterization, and biodistribution of breviscapine proliposomes in heart.
PubMed: [The effect of polyamidoamine (PAMAM) dendrimers on the solubility and pharmacokinetics of breviscapine].
PubMed: [Effects of Dengzhan Xixin on blood-brain barrier permeability and metabolites after cerebral ischemia-reperfusion injuries].
PubMed: [Effects of in vitro conditions on release behavior of different types of sustained and controlled release formulations of breviscapin].
PubMed: Breviscapine, a traditional Chinese medicine, alleviates myocardial ischaemia reperfusion injury in diabetic rats.
PubMed: [The effect of breviscapine on the pulmonary arterial pressure and the expression of Rho-kinase in pulmonary arterioles of hypoxic rats].
PubMed: Studies on antioxidant activities of breviscapine in the cell-free system.
PubMed: Dengzhanhua preparations for acute cerebral infarction.
PubMed: Comparative pharmacokinetics of breviscapine liposomes in dogs, rabbits and rats.
PubMed: Pharmacokinetics and biodistribution of surface modification polymeric nanoparticles.
PubMed: Effect of ion-pairing and enhancers on scutellarin skin permeability.
PubMed: Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats.
PubMed: Breviscapine alleviates hepatic injury and inhibits PKC-mRNA and its protein expression in brain-dead BA-Ma mini pigs.
PubMed: [Effect of Erigeron Breviscapine on premaxillary suture distraction osteogenesis in rabbit].
PubMed: Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats.
PubMed: [Protective effects of breviscapine against cultured rat hippocampal neuronal toxicity induced by glutamate].
PubMed: Isolation and identification of ten metabolites of breviscapine in rat urine.
PubMed: Prevention of early liver injury by breviscapine in streptozotocin-induced diabetic rats.
PubMed: Two major urinary metabolites of scutellarin in rats.
PubMed: Amelioration of graft ischemia-reperfusion injury by breviscapine in rat small bowel transplantation.
PubMed: [Protective effects of Denghuang injection on cerebral infarction in animal].
PubMed: Effect of breviscapine on fractalkine expression in chronic hypoxic rats.
PubMed: Protective effects of breviscapine on ischemic vascular dementia in rats.
PubMed: Renoprotective effect of breviscapine through suppression of renal macrophage recruitment in streptozotocin-induced diabetic rats.
PubMed: [How brain-dead state affects the hepatic morphology and function of Ba-Ma mini pigs and its mechanism].
PubMed: [Pharmacokinetics of breviscapine liposomes following intravenous injection in Beagle dogs].
PubMed: Preparation and pharmacokinetics in rabbits of breviscapine unilamellar vesicles.
PubMed: [Pharmacokinetics of breviscapine in dogs and rabbits following single intravenous administration].
PubMed: Distribution of liposomal breviscapine in brain following intravenous injection in rats.
PubMed: Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats.
PubMed: Determination of aglycone conjugated metabolites of scutellarin in rat plasma by HPLC.
PubMed: [Pharmacokinetics of breviscapine and its beta-cyclodextrin complex in rats].
PubMed: Multivesicular liposome formulation for the sustained delivery of breviscapine.
PubMed: Enhanced oral bioavailability of breviscapine after encapsulation in a liposomal formulation.
PubMed: Clinical observation on Breviscapine in treating hypertension patients complicated with micro-albuminuria of renal impairment.
PubMed: [Enhanced absorption of breviscapine photosomes in small intestine of rats].
PubMed: [Determination of entrapment efficiency of breviscapine nanoliposomes].
PubMed: [Regulation of pre-mRNA alternative spicing in U251 cells by TPA].
PubMed: A study of the cardioprotective effect of breviscapine during hypoxia of cardiomyocytes.
PubMed: Study on pharmacokinetics of scutellarin in rabbits.
PubMed: [Pharmacokinetics of scutellarin in rabbits].
PubMed: [Effect of breviscapine on urinary micro-albumine in patients with diabetes mellitus type 2].
PubMed: [Regulation of the expression of pulmonary arterial collagen by protein kinase C and breviscapine in chronic hypoxic rats].
PubMed: Differential effects of new breviscapine on arachidonic acid metabolisms in blood cells and endothelial cells.
PubMed: Effect of new-breviscapine on fibrinolysis and anticoagulation of human vascular endothelial cells.
PubMed: [An experimental study on the anti-reoxidation injury on myocardium of Erigeron breviscapus].
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