gossypol acetate
(2,2'-binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-, hexaacetate
 
Notes:
None found
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CAS Number: 30719-67-6Picture of molecule3D/inchi
Other(deleted CASRN): 109968-48-1
Nikkaji Web: J126.058H
XlogP3-AA: 6.50 (est)
Molecular Weight: 770.78554000
Formula: C42 H42 O14
BioActivity Summary: listing
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Category: natural substances and extractives
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 836.28 °C. @ 760.00 mm Hg (est)
Flash Point: 631.00 °F. TCC ( 332.90 °C. ) (est)
logP (o/w): 5.028 (est)
Soluble in:
 water, 5.134e-008 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for gossypol acetate usage levels up to:
 not for fragrance use.
 
Recommendation for gossypol acetate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
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EPA ACToR: Toxicology Data
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Laboratory Chemical Safety Summary : 35450
National Institute of Allergy and Infectious Diseases: Data
 [3,8-diacetyloxy-1-formyl-6-methyl-4-propan-2-yl-7-(1,6,7-triacetyloxy-8-formyl-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalen-2-yl] acetate
Chemidplus: 0030719676
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References:
 [3,8-diacetyloxy-1-formyl-6-methyl-4-propan-2-yl-7-(1,6,7-triacetyloxy-8-formyl-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalen-2-yl] acetate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 35450
Pubchem (sid): 135000276
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
(2,2'-binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-, hexaacetate
[2,2'-binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexakis(acetyloxy)-3,3'-dimethyl-5,5'-bis(1-methylethyl)-
[3,8-diacetyloxy-1-formyl-6-methyl-4-propan-2-yl-7-(1,6,7-triacetyloxy-8-formyl-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalen-2-yl] acetate
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Articles:
PubMed: Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.
PubMed: [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone].
PubMed: [Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line].
PubMed: [Effect of liuwei dihuang decoction and its additives on boosting spermatogenesis in spermatogenesis obstruction rat].
PubMed: In vitro effect of gossypol acetate on yellow perch (Perca flavescens) spermatozoa.
PubMed: Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia).
PubMed: [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells].
PubMed: Non-steroidal antifertility agents.
PubMed: Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats.
PubMed: Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells.
PubMed: Effects of gossypol acetate on pituitary-adrenal axis in male albino rats.
PubMed: [Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ].
PubMed: [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro].
PubMed: Studies on mechanism(s) of antifertility action of gossypol in rat and hamster.
PubMed: [Effect of gossypol acetate on the testicular HCG reactivity and its receptor in the rats].
PubMed: Sites of action of gossypol studied by autoradiography and enzyme histochemistry.
PubMed: Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships.
PubMed: Inhibition of glycerolipid synthesis by gossypol acetate.
PubMed: Cytogenetic analysis of a gossypol-induced murine myxosarcoma.
PubMed: Antifertility treating with long term gossypol.
PubMed: Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis.
PubMed: [Gossypol acetate users].
PubMed: [Synergic effects of gossypol acetate and sulphadiazine on the LDH-x activity and viability of human sperm].
PubMed: Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro.
PubMed: [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes].
PubMed: Gossypol-induced inhibition of guinea pig sperm capacitation in vitro.
PubMed: [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells].
PubMed: [Effects of gossypol acetate on neuromuscular transmission (author's transl)].
PubMed: Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats.
PubMed: [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)].
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