galantamine hydrobromide
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
 
Notes:
a benzazepine derived from norbelladine. it is found in galanthus and other amaryllidaceae. it is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine and has been studied as a treatment for alzheimer disease and other central nervous system disorders.
  • BOC Sciences
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      Product(s):
      1953-04-4 Galanthamine hydrobromide 97.5% (TLC).
      Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents a-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. ADCs Cytotoxin
       
       
  • Jiangyin Healthway
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      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
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      Product(s):
      166748 Galantamine Hydrobromide
       
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      Product(s):
      G0293 Galantamine Hydrobromide >98.0%(HPLC)(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 1953-04-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 217-780-5
FDA UNII: MJ4PTD2VVW
MDL: MFCD00067672
Molecular Weight: 368.27094000
Formula: C17 H22 Br N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 439.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 427.00 °F. TCC ( 219.50 °C. ) (est)
logP (o/w): 1.750 (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Galanthamine hydrobromide 98%
BOC Sciences
For experimental / research use only.
Galanthamine hydrobromide 97.5% (TLC).
Odor: characteristic
Use: Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents a-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. ADCs Cytotoxin
Changsha Organic Herb
Galanthamine HBr Hydrobromide - Lycoris Radiate Extract
Jiangyin Healthway
Galantamine Hydrobromide
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
Galantamine Hydrobromide
Sigma-Aldrich
For experimental / research use only.
Galantamine Hydrobromide
European Pharmacopoeia (EP) Reference Standard
TCI AMERICA
For experimental / research use only.
Galantamine Hydrobromide >98.0%(HPLC)(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for galantamine hydrobromide usage levels up to:
 not for fragrance use.
 
Recommendation for galantamine hydrobromide flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 121587
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0001953044
RTECS: DF8075000 for cas# 1953-04-4
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 121587
Pubchem (sid): 135263390
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
KEGG (GenomeNet): D02173
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2934.99.4400
MedlinePlusSupp: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•razadyne •oral: solution: 4 mgml (of galantamine), (reminyl), (janssen). tablets: 4 mg (of galantamine), (reminyl), (janssen); 8 mg (of galantamine), (reminyl), (janssen); 12 mg (of galantamine), (reminyl), (janssen). galantamine hydrobromide
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide
6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1)
 galanthamine bromhydrate (1:1)
 galanthamine HBr
 galanthamine hydrobromide
 galanthamine hydrobromide (1:1)
 galanthamine hydrobromide from lycoris sp.
 galanthamine hydrogen bromide
 galanthamine hydrogenbromide
 galanthaminehydrobromide
 galanthaminhydrobromid(1:1)
 lycoremine hydrobromide
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
 nivaline
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Articles:
PubMed: Gypsogenin Derivatives: An Unexpected Class of Inhibitors of Cholinesterases.
PubMed: Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry.
PubMed: Benzophenones from Hypericum elegans with antioxidant and acetylcholinesterase inhibitory potential.
PubMed: Synthesis of imperatorin analogs and their evaluation as acetylcholinesterase and butyrylcholinesterase inhibitors.
PubMed: Quantification of galantamine in human plasma by validated liquid chromatography-tandem mass spectrometry using glimepride as an internal standard: application to bioavailability studies in 32 healthy Korean subjects.
PubMed: Controlled release reservoir mini tablets approach for controlling the drug release of Galantamine Hydrobromide.
PubMed: Development and in vivo evaluation of novel monolithic controlled release compositions of galantamine hydrobromide as against reservoir technology.
PubMed: Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide.
PubMed: The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.
PubMed: Galantamine is a novel post-exposure therapeutic against lethal VX challenge.
PubMed: Bullous pemphigoid precipitated by galantamine hydrobromide.
PubMed: Optimal dosing of galantamine in patients with mild or moderate Alzheimer's disease: post Hoc analysis of a randomized, double-blind, placebo-controlled trial.
PubMed: A double-blind comparison of galantamine hydrobromide ER and placebo in Parkinson disease.
PubMed: [Criminal clozapine intoxications].
PubMed: Pharmacokinetics and bioequivalence studies of galantamine hydrobromide dispersible tablet in healthy male Chinese volunteers.
PubMed: Cholinesterase inhibitors in the treatment of dementia.
PubMed: Capillary electrophoresis-mass spectrometry in impurity profiling of pharmaceutical products.
PubMed: A prospective, double-blind, community-controlled comparison of three doses of galantamine in the treatment of mild to moderate Alzheimer's disease in a Korean population.
PubMed: Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial.
PubMed: The clinical efficacy and safety of galantamine in the treatment of Alzheimer's disease.
PubMed: Pharmacokinetics and tissue distribution of galantamine and galantamine-related radioactivity after single intravenous and oral administration in the rat.
PubMed: The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial.
PubMed: Antioxidant properties of galantamine hydrobromide.
PubMed: Galantamine hydrobromide: an agent for Alzheimer's disease.
PubMed: Gateways to clinical trials.
PubMed: Gateways to clinical trials.
PubMed: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease.
PubMed: Gateways to Clinical Trials. June 2002.
PubMed: Galantamine hydrobromide.
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