Articles:
13a-a-berbine, 2,3,9,10-tetramethoxy-
Notes:
None found
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 10097-84-4 Tetrahydropalmatin >98% Rotundine, that is isolated from the root of Stephania tetrandra S. Moore, has significant effect of analgesia at 15min (P=0.022<0.05) and at 30min (P=0.022<0.05). It is ineffective in 60min. Rotundine may be a useful drug for suppressing morphine tolera Antinociceptive
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| CAS Number: | 10097-84-4 |  3D/inchi
|
| FDA UNII: | 3X69CO5I79 | |
| Nikkaji Web: | J31.887F | |
| XlogP3-AA: | 3.20 (est) | |
| Molecular Weight: | 355.43405000 | |
| Formula: | C21 H25 N O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 482.87 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 282.00 °F. TCC ( 138.70 °C. ) (est) |
| logP (o/w): | 0.591 (est) |
| Soluble in: | |
| water, 85.84 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Tetrahydropalmatin >98%
Odor: characteristic Use: Rotundine, that is isolated from the root of Stephania tetrandra S. Moore, has significant effect of analgesia at 15min (P=0.022<0.05) and at 30min (P=0.022<0.05). It is ineffective in 60min. Rotundine may be a useful drug for suppressing morphine tolera
Antinociceptive |
| Changsha Organic Herb |
| Corydalis Yanhusuo Extract |
| Coompo |
| For experimental / research use only. |
| Rotundine from Plants ≥98%
Odor: characteristic Use: Rotundine at 20 mg/kg given subcutaneously (s.c.), which by itself did not produce any antinociceptive effect, significantly inhibited the development of tolerance. The physical dependence was evaluated in male rats. The behavioral signs including jumping, wet-dog shakes, teeth chattering, writhing, diarrhea, ptosis and vocalizing on touch, were observed. Withdrawal was precipitated by a single injection of naloxone in dependent rats. Rotundine (20 mg/kg, s.c.) suppressed jumping, teeth chattering, diarrhea and irritability but not other signs of physical dependence in the rat. The psychic dependence was assessed by the conditioned place preference in male mice. Rotundine (20 mg/kg s.c.), significantly attenuated the place preference induced by morphine. The results suggest that rotundine may be a useful drug for suppressing morphine tolerance and withdrawal symptoms.
Rotundine has significant effect of analgesia at 15min (P=0.022<0.05) and at 30min (P=0.022<0.05). It is ineffective in 60min.Rotundine is used for producing tranquilliser with safe sleeping effect and without side-effects. |
| Nacalai USA |
| For experimental / research use only. |
| dl-Tetrahydropalmatine |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| L-Tetrahydropalmatine |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 100 mg/kg French Medicament Patent Document. Vol. #4818M | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for tetrahydropalmatine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for tetrahydropalmatine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 72301 |
| National Institute of Allergy and Infectious Diseases: | Data |
| (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline | |
| Chemidplus: | 0010097844 |
References:
| (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 72301 |
| Pubchem (sid): | 135076267 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C02890 |
| HMDB (The Human Metabolome Database): | Search |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| corydalis yanhusuo Search Trop Picture | |
| tithomia rotundifolia Search Trop Picture |
Synonyms:
| 13a-a- | berbine, 2,3,9,10-tetramethoxy- |
| caseanine | |
| (-)- | corydalis |
| 6H- | dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (S)- |
| 6H- | dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)- |
| 6h- | dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-,(13as)- |
| gindarine | |
| hyndarin | |
| hyndarine | |
| rotundine | |
| (S)-5,8,13,13a- | tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizine |
| 5,8,13,13a- | tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizine |
| 5,8,13,13a(S)- | tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine |
| (-)- | tetrahydropalmatine |
| 2,3,9,10- | tetramethoxy-13aa-berbine |
| (13aS)-2,3,9,10- | tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline |
| (S)-2,3,9,10- | tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline |
| 2,3,9,10- | tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline |
| (13aS)-2,3,9,10- | tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| (S)-2,3,9,10- | tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline |