| PubMed: | RNAi-mediated pinoresinol lariciresinol reductase gene silencing in flax (Linum usitatissimum L.) seed coat: Consequences on lignans and neolignans accumulation. |
| PubMed: | Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage. |
| PubMed: | The impact of dietary isoflavonoids on malignant brain tumors. |
| PubMed: | Ruminal Prevotella spp. may play an important role in the conversion of plant lignans into human health beneficial antioxidants. |
| PubMed: | Identification and functional characterization of a flax UDP-glycosyltransferase glucosylating secoisolariciresinol (SECO) into secoisolariciresinol monoglucoside (SMG) and diglucoside (SDG). |
| PubMed: | Isolation, characterization and antihyperlipidemic activity of secoisolariciresinol diglucoside in poloxamer-407-induced experimental hyperlipidemia. |
| PubMed: | Secoisolariciresinol Diglucoside (SDG) Isolated from Flaxseed, an Alternative to ACE Inhibitors in the Treatment of Hypertension. |
| PubMed: | Permeability and conjugative metabolism of flaxseed lignans by Caco-2 human intestinal cells. |
| PubMed: | Phenolic compounds in flaxseed: a review of their properties and analytical methods. An overview of the last decade. |
| PubMed: | Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process. |
| PubMed: | Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). |
| PubMed: | Cloning, expression, and characterization of the β-glucosidase hydrolyzing secoisolariciresinol diglucoside to secoisolariciresinol from Bacteroides uniformis ZL1. |
| PubMed: | Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity. |
| PubMed: | Radiation mitigating properties of the lignan component in flaxseed. |
| PubMed: | Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats. |
| PubMed: | Flaxseed - a miraculous defense against some critical maladies. |
| PubMed: | The biomedical potential of genetically modified flax seeds overexpressing the glucosyltransferase gene. |
| PubMed: | Investigation of in vitro and in vivo antioxidant potential of secoisolariciresinol diglucoside. |
| PubMed: | Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). |
| PubMed: | Flaxseed lignan complex administration in older human type 2 diabetics manages central obesity and prothrombosis-an invitation to further investigation into polypharmacy reduction. |
| PubMed: | Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells. |
| PubMed: | Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms. |
| PubMed: | Production of secoisolariciresinol from defatted flaxseed by bacterial biotransformation. |
| PubMed: | [Nutritional value and functional properties of flaxseed]. |
| PubMed: | Lignans in seeds of Linum species. |
| PubMed: | [Effects of secoisolariciresinol diglucoside combined with bortezomib on induction of apoptosis in lung cancer cell line A549]. |
| PubMed: | Concentration kinetics of secoisolariciresinol diglucoside and its biosynthetic precursor coniferin in developing flaxseed. |
| PubMed: | Flaxseed bioactive compounds change milk, hormonal and biochemical parameters of dams and offspring during lactation. |
| PubMed: | Potential effects of lignan-enriched flaxseed powder on bodyweight, visceral fat, lipid profile, and blood pressure in rats. |
| PubMed: | A review of animal and human studies for management of benign prostatic hyperplasia with natural products: perspective of new pharmacological agents. |
| PubMed: | Qualitative and quantitative analysis of the major phenolic compounds as antioxidants in barley and flaxseed hulls using HPLC/MS/MS. |
| PubMed: | Comparative effects of sesame seed lignan and flaxseed lignan in reducing the growth of human breast tumors (MCF-7) at high levels of circulating estrogen in athymic mice. |
| PubMed: | Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer. |
| PubMed: | [Effects of flaxseed extract on rheological properties of blood in experimental ovariectomy]. |
| PubMed: | Abscisic acid regulates pinoresinol-lariciresinol reductase gene expression and secoisolariciresinol accumulation in developing flax (Linum usitatissimum L.) seeds. |
| PubMed: | Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside. |
| PubMed: | Effects of flaxseed lignan and oil on bone health of breast-tumor-bearing mice treated with or without tamoxifen. |
| PubMed: | IR and Raman studies of oil and seedcake extracts from natural and genetically modified flax seeds. |
| PubMed: | Effect of flaxseed lignans added to milk or fed to cows on oxidative degradation of dairy beverages enriched with polyunsaturated fatty acids. |
| PubMed: | Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside. |
| PubMed: | Natural products in regression and slowing of progression of atherosclerosis. |
| PubMed: | Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. |
| PubMed: | Extraction of lignans from flaxseed and evaluation of their biological effects on breast cancer MCF-7 and MDA-MB-231 cell lines. |
| PubMed: | The effect of secoisolariciresinol diglucoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways. |
| PubMed: | Bacterial transformation of dietary lignans in gnotobiotic rats. |
| PubMed: | Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. |
| PubMed: | Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways. |
| PubMed: | Concentration of the mammalian lignans enterolactone and enterodiol in milk of cows fed diets containing different concentrations of whole flaxseed. |
| PubMed: | Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice. |
| PubMed: | Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. |
| PubMed: | Weekly excretion of the mammalian lignan enterolactone in milk of dairy cows fed flaxseed meal. |
| PubMed: | Further studies on a human intestinal bacterium Ruminococcus sp. END-1 for transformation of plant lignans to mammalian lignans. |
| PubMed: | Flaxseed and cardiovascular health. |
| PubMed: | Ruminal metabolism of flaxseed ( Linum usitatissimum) lignans to the mammalian lignan enterolactone and its concentration in ruminal fluid, plasma, urine and milk of dairy cows. |
| PubMed: | Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal. |
| PubMed: | Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats. |
| PubMed: | The chain length of lignan macromolecule from flaxseed hulls is determined by the incorporation of coumaric acid glucosides and ferulic acid glucosides. |
| PubMed: | Patented techniques for the extraction and isolation of secoisolari-ciresinol diglucoside from flaxseed. |
| PubMed: | Determination of lignans in flaxseed using liquid chromatography with time-of-flight mass spectrometry. |
| PubMed: | Hydrolysis kinetics of secoisolariciresinol diglucoside oligomers from flaxseed. |
| PubMed: | Validation of a reversed phase high performance thin layer chromatographic-densitometric method for secoisolariciresinol diglucoside determination in flaxseed. |
| PubMed: | Effect of feeding flax or linseed meal on progesterone clearance rate in ovariectomized ewes. |
| PubMed: | The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. |
| PubMed: | Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem. |
| PubMed: | Lignans are accessible to human breast cancer xenografts in athymic mice. |
| PubMed: | Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. |
| PubMed: | Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the flaxseed extract by high-performance liquid chromatography. |
| PubMed: | Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. |
| PubMed: | Hydroxycinnamic acids are ester-linked directly to glucosyl moieties within the lignan macromolecule from flaxseed hulls. |
| PubMed: | Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. |
| PubMed: | Enhancing lignan biosynthesis by over-expressing pinoresinol lariciresinol reductase in transgenic wheat. |
| PubMed: | Secoisolariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hypercholesterolemic myocardium. |
| PubMed: | Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria. |
| PubMed: | Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. |
| PubMed: | Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. |
| PubMed: | Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro. |
| PubMed: | Microwave-assisted extraction of the main phenolic compounds in flaxseed. |
| PubMed: | Determination of mammalian lignans in biological samples by modified gas chromatography/mass spectrometry. |
| PubMed: | Purification of secoisolariciresinol diglucoside with column chromatography on a sephadex LH-20. |
| PubMed: | Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone. |
| PubMed: | Feeding flaxseed oil but not secoisolariciresinol diglucoside results in higher bone mass in healthy rats and rats with kidney disease. |
| PubMed: | AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG. |
| PubMed: | Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside. |
| PubMed: | The flavonoid herbacetin diglucoside as a constituent of the lignan macromolecule from flaxseed hulls. |
| PubMed: | Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury. |
| PubMed: | Effect of processing and storage on the stability of flaxseed lignan added to dairy products. |
| PubMed: | Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism. |
| PubMed: | Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women. |
| PubMed: | Assessing exposure to lignans and their metabolites in humans. |
| PubMed: | Flax lignans--analytical methods and how they influence our lunderstanding of biological activity. |
| PubMed: | Pinoresinol-lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax (Linum usitatissimum) seeds. |
| PubMed: | Occurrence and activity of human intestinal bacteria involved in the conversion of dietary lignans. |
| PubMed: | Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats. |
| PubMed: | High accumulation of dehydrodiconiferyl alcohol-4-beta-D: -glucoside in free and immobilized Linum usitatissimum cell cultures. |
| PubMed: | Contribution of linseed intake to urine and serum enterolignan levels in German females: a randomised controlled intervention trial. |
| PubMed: | Analysis of enterolignan glucuronides in serum and urine by HPLC-ESI-MS. |
| PubMed: | Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside. |
| PubMed: | Effect of processing and storage on the stability of flaxseed lignan added to bakery products. |
| PubMed: | A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women. |
| PubMed: | Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans. |
| PubMed: | Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. |
| PubMed: | Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside. |
| PubMed: | Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed. |
| PubMed: | High-performance thin-layer chromatographic-densitometric determination of secoisolariciresinol diglucoside in flaxseed. |
| PubMed: | The effects of dietary flaxseed on the Fischer 344 rat: II. Liver gamma-glutamyltranspeptidase activity. |
| PubMed: | Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. |
| PubMed: | Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats. |
| PubMed: | The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress. |
| PubMed: | Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein E and low-density lipoprotein receptor deficient mice. |
| PubMed: | High-performance liquid chromatographic analysis of secoisolariciresinol diglucoside and hydroxycinnamic acid glucosides in flaxseed by alkaline extraction. |
| PubMed: | Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis. |
| PubMed: | Flaxseed: a source of hypocholesterolemic and antiatherogenic agents. |
| PubMed: | Transformation of arctiin to estrogenic and antiestrogenic substances by human intestinal bacteria. |
| PubMed: | On-line liquid-chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry coupling for the separation and characterization of secoisolariciresinol diglucoside isomers in flaxseed. |
| PubMed: | Isolation of the lignan secoisolariciresinol diglucoside from flaxseed (Linum usitatissimum L.) by high-speed counter-current chromatography. |
| PubMed: | Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucoside-hydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed. |
| PubMed: | An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl glutaric acid residues. |
| PubMed: | Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat. |
| PubMed: | Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures. |
| PubMed: | HPLC method for analysis of secoisolariciresinol diglucoside in flaxseeds. |
| PubMed: | Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone. |
| PubMed: | Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. |
| PubMed: | Antioxidant Activity of Secoisolariciresinol Diglucoside-derived Metabolites, Secoisolariciresinol, Enterodiol, and Enterolactone. |
| PubMed: | Quantitation of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. |
| PubMed: | Urinary composition and postprandial blood changes in H-secoisolariciresinol diglycoside (SDG) metabolites in rats do not differ between acute and chronic SDG treatments. |
| PubMed: | Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: effect of secoisolariciresinol diglucoside (SDG). |
| PubMed: | Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism. |
| PubMed: | Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. |
| PubMed: | Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats. |
| PubMed: | Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice. |
| PubMed: | Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. |
| PubMed: | Chronic exposure to secoisolariciresinol diglycoside alters lignan disposition in rats. |
| PubMed: | Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. |
| PubMed: | Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. |
| PubMed: | The influence of flaxseed and lignans on colon carcinogenesis and beta-glucuronidase activity. |
| PubMed: | Investigation of mammalian lignan precursors in flax seed: first evidence of secoisolariciresinol diglucoside in two isomeric forms by liquid chromatograph/mass spectrometry. |
| PubMed: | Revealing the mammalian lignan precursor secoisolariciresinol diglucoside in flax seed by ionspray mass spectrometry. |