Articles:
morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)
Notes:
None found
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 637-58-1 Pramoxine HCl >98% Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulse
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): PRAMOXINE HCL
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 16-65100 PRAMOXINE HYDROCHLORIDE USP
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| CAS Number: | 637-58-1 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 211-293-1 | |
| FDA UNII: | 88AYB867L5 | |
| MDL: | MFCD00054323 | |
| Molecular Weight: | 329.86676000 | |
| Formula: | C17 H28 Cl N O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 181.00 °C. @ 760.00 mm Hg (est) |
| Boiling Point: | 427.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 254.00 °F. TCC ( 123.50 °C. ) (est) |
| logP (o/w): | 3.477 (est) |
| Soluble in: | |
| water, 190.6 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Pramoxine HCl >98%
Odor: characteristic Use: Pramoxine is a topical local anesthetic that has been shown to have antipruritic properties.Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulse |
| Charkit Chemical |
| PRAMOXINE HCL |
| George Uhe Company |
| Pramoxine HCL |
| Penta International |
| PRAMOXINE HYDROCHLORIDE USP |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Pramoxine Hydrochloride |
| Sigma-Aldrich |
| For experimental / research use only. |
| Pramoxine Hydrochloride ≥98% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-guinea pig LDLo 109 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CARDIAC OUTPUT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957. intraperitoneal-mouse LD50 460 mg/kg "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. intravenous-mouse LD50 79500 ug/kg Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959. oral-mouse LD50 1050 mg/kg "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. intravenous-rabbit LD50 39 mg/kg "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 1470 mg/kg CARDIAC: CARDIAC OUTPUT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for pramoxine hydrochloride usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for pramoxine hydrochloride flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 73957 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride | |
| Chemidplus: | 0000637581 |
| RTECS: | QD8750000 for cas# 637-58-1 |
References:
| 4-[3-(4-butoxyphenoxy)propyl]morpholine;hydrochloride | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 73957 |
| Pubchem (sid): | 135032174 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| KEGG (GenomeNet): | D00739 |
| HMDB (The Human Metabolome Database): | Search |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: rectal or topical: aerosol, foam suspension: 1% proctofoamnon-steroid (with parabens), (schwarz); cream: 1% tronolane (with parabens), (ross). topical: 1% hemorrhoidal anesthetic cream, (clay-park), tronothane hydrochloride (with parabens), (ross); gell: 1% itch-x (with sd alcohol 40, benzyl alcohol 10%, parabens, and propylene glycol), (ascher), pramegel (with benzyl alcohol and menthol), (genderm); lotion: 1% prax lotion, (ferndale); pledgets (saturated with solution): 1% fleet pain-relief pads (with glycerin 12.5%), (fleet); solution: 1% itch-x spray (with benzyl alcohol 10%), (ascher). | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 4-(3-(p- | butoxyphenoxy)propyl)morpholine hydrochloride |
| 4-[3-(4- | butoxyphenoxy)propyl]morpholine hydrochloride |
| 4-[3-(p- | butoxyphenoxy)propyl]morpholine hydrochloride |
| 4-[3-(4- | butoxyphenoxy)propyl]morpholine hydrochloride (1:1) |
| 4-[3-(4- | butoxyphenoxy)propyl]morpholine;hydrochloride |
| p- | butoxyphenyl g-morpholinopropyl ether hydrochloride |
| morpholine, 4-(3-(4-butoxyphenoxy)propyl)-, hydrochloride | |
| morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, hydrochloride | |
| morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1) | |
| g- | morpholinopropyl 4-N-butoxyphenyl ether hydrochloride |
| pramocaine hydrochloride | |
| pramoxine HCl | |
| proctocream-HC | |
| proxazocain hydrochloride | |
| tronolane | |
| tronothane hydrochloride |