diacerein, 13739-02-1

Articles:

PubMed:	Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters.
PubMed:	Current Treatment Options for Osteoarthritis.
PubMed:	Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats.
PubMed:	Efficacy and Safety of Diacerein in Patients With Inadequately Controlled Type 2 Diabetes: A Randomized Controlled Trial.
PubMed:	Chitosan-coated diacerein nanosuspensions as a platform for enhancing bioavailability and lowering side effects: preparation, characterization, and ex vivo/in vivo evaluation.
PubMed:	Quantitative analysis of anti-inflammatory drugs using FTIR-ATR spectrometry.
PubMed:	Erratum to: Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO.
PubMed:	Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells.
PubMed:	The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats.
PubMed:	Effect of diacerein as an add-on to metformin in patients with type 2 diabetes mellitus and inadequate glycemic control.
PubMed:	Somatostatin receptor targeted liposomes with Diacerein inhibit IL-6 for breast cancer therapy.
PubMed:	Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system.
PubMed:	Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis.
PubMed:	Efficacy of glucosamine plus diacerein versus monotherapy of glucosamine: a double-blind, parallel randomized clinical trial.
PubMed:	Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis.
PubMed:	Ultrasonic Processing Technique as a Green Preparation Approach for Diacerein-Loaded Niosomes.
PubMed:	Development and in-vitro characterization of sorbitan monolaurate and poloxamer 184 based niosomes for oral delivery of diacerein.
PubMed:	Suppression of Cartilage Degradation by Zingerone Involving the p38 and JNK MAPK Signaling Pathway.
PubMed:	[The Analysis of Efficacy of The Application of Interleukin-1 Inhibitor in the Complex Therapy of Secondary Osteoarthritis Taking Into Account the Dynamics of Clinical and Functional Indicators].
PubMed:	Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice.
PubMed:	In Vitro Chondroprotective Potential of Extracts Obtained from Various Phyllantus Species.
PubMed:	Non-surgical treatments for the management of early osteoarthritis.
PubMed:	Melanosis coli due to diacerein.
PubMed:	Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats.
PubMed:	Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO.
PubMed:	Lecithin-gold hybrid nanocarriers as efficient and pH selective vehicles for oral delivery of diacerein-In-vitro and in-vivo study.
PubMed:	Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: Results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study.
PubMed:	Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer.
PubMed:	Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.
PubMed:	Multi-drug intoxication fatality involving atorvastatin: A case report.
PubMed:	Diacerein reduces joint damage, pain behavior and inhibits transient receptor potential vanilloid 1, matrix metalloproteinase and glial cells in rat spinal cord.
PubMed:	Design and synthesis of aloe-emodin derivatives as potent anti-tyrosinase, antibacterial and anti-inflammatory agents.
PubMed:	Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats.
PubMed:	Diacerein: A potential therapeutic drug for the management of experimental periodontitis in rats.
PubMed:	Development and Pharmacokinetic Evaluation of New Oral Formulations of Diacerein.
PubMed:	Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model.
PubMed:	[Treatment for knee osteoarthritis in patients with oxalate nephropathy].
PubMed:	Combination Therapies of Diacerein and Febuxostat Inhibit IL-1β Responses and Improve Clinical Symptoms in Patients With Refractory Gout.
PubMed:	Novel self-nanoemulsifying self-nanosuspension (SNESNS) for enhancing oral bioavailability of diacerein: Simultaneous portal blood absorption and lymphatic delivery.
PubMed:	Comparison of various SYSADOA for the osteoarthritis treatment: an experimental study in rabbits.
PubMed:	Diacerein. A controversial EU re-evaluation upholds marketing authorisation, unfortunately.
PubMed:	Solid and liquid lipid-based binary solid lipid nanoparticles of diacerein: in vitro evaluation of sustained release, simultaneous loading of gold nanoparticles, and potential thermoresponsive behavior.
PubMed:	Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis.
PubMed:	Diacerein niosomal gel for topical delivery: development, in vitro and in vivo assessment.
PubMed:	Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development and in vitro characterization.
PubMed:	Diacerein improves left ventricular remodeling and cardiac function by reducing the inflammatory response after myocardial infarction.
PubMed:	Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways.
PubMed:	Diacerein-thymol prodrug: in vivo release and pharmacological screening in experimental models of osteoarthritis in Wistar rats.
PubMed:	Benefit-risk assessment of diacerein in the treatment of osteoarthritis.
PubMed:	Supplementary methods in the nonsurgical treatment of osteoarthritis.
PubMed:	[Correction of an inflammatory process with an interleukin-1 inhibitor in the combination treatment of secondary osteoarthritis in the presence of comorbid condition].
PubMed:	Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model.
PubMed:	Diacerein is a potent and selective inhibitor of palmitoylethanolamide inactivation with analgesic activity in a rat model of acute inflammatory pain.
PubMed:	Experimental osteoarthritis model by means of medial meniscectomy in rats and effects of diacerein administration and hyaluronic acid injection.
PubMed:	Combination of diacerhein and antiepileptic drugs after local peripheral, and oral administration in the rat formalin test.
PubMed:	Nanosizing of a poorly soluble drug: technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers.
PubMed:	The disease modifying osteoarthritis drug diacerein is able to antagonize pro inflammatory state of chondrocytes under mild mechanical stimuli.
PubMed:	Stability-indicating HPLC method for quantification of celecoxib and diacerein along with its impurities in capsule dosage form.
PubMed:	Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages.
PubMed:	Spectroscopic characterization of both aqueous and solid-state diacerhein/hydroxypropyl-β-cyclodextrin inclusion complexes.
PubMed:	Simultaneous spectrophotometric determination of celecoxib and diacerein in bulk and capsule by absorption correction method and chemometric methods.
PubMed:	Diacerein for osteoarthritis.
PubMed:	Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats.
PubMed:	OARSI guidelines for the non-surgical management of knee osteoarthritis.
PubMed:	[The pathogenetic substantiation of new therapeutic approach to the treatment of secondary osteoarthritis in patients with rheumatoid arthritis with basis therapy].
PubMed:	The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination.
PubMed:	Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects.
PubMed:	Disease-modifying effect of anthraquinone prodrug with boswellic acid on collagenase-induced osteoarthritis in Wistar rats.
PubMed:	Topical diacerein for epidermolysis bullosa: a randomized controlled pilot study.
PubMed:	The efficacy of diacerein in hand osteoarthritis: a double-blind, randomized, placebo-controlled study.
PubMed:	Disease-modifying osteoarthritis drugs: in vitro and in vivo data on the development of DMOADs under investigation.
PubMed:	The pathogenetic role of IL-1β in severe epidermolysis bullosa simplex.
PubMed:	Validated stability indicating TLC-densitometric method for the determination of diacerein.
PubMed:	Studies on synthesis, stability, release and pharmacodynamic profile of a novel diacerein-thymol prodrug.
PubMed:	Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate.
PubMed:	Nutraceuticals in the management of osteoarthritis : a critical review.
PubMed:	[Clinical study of Qianggu granule and diacerein capsule in treating knee osteoarthritis].
PubMed:	Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia.
PubMed:	Diacerhein attenuates the inflammatory response and improves survival in a model of severe sepsis.
PubMed:	Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system.
PubMed:	Diacerein decreases visceral pain through inhibition of glutamatergic neurotransmission and cytokine signaling in mice.
PubMed:	[Management of osteoarthritis: oral therapies].
PubMed:	Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.
PubMed:	Fast-dissolving and high-drug-loaded, Fatty Acid-based self-emulsifying solid dispersions of diacerein.
PubMed:	Diacerein: a potential therapeutic drug for periodontal disease.
PubMed:	[Clinical efficacy of bushen huoxue qubi decoction on treatment of knee-osteoarthritis and its effect on hemarheology, anti-inflammation and antioxidation].
PubMed:	Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.
PubMed:	Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.
PubMed:	Quantitative estimation of diacerein in bulk and in capsule formulation using hydrotropic solubilizing agents by UV-spectrophotometry and the first order derivative using the area under curve method.
PubMed:	A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.
PubMed:	[Pharmacological therapies for osteoarthritis].
PubMed:	Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
PubMed:	Diacerhein improves glucose tolerance and insulin sensitivity in mice on a high-fat diet.
PubMed:	Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial.
PubMed:	Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.
PubMed:	Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000.
PubMed:	Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study.
PubMed:	Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
PubMed:	Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms.
PubMed:	Stress degradation studies and development of a validated stability-indicating-assay-method for determination of diacerein in presence of degradation products.
PubMed:	Improvement in the dissolution profile of diacerein using a surfactant-based solid dispersion technique.
PubMed:	Are FoxO transcription factors implicated in osteoarthritis? Influence of Diacerhein.
PubMed:	Effects of diacerein at the molecular level in the osteoarthritis disease process.
PubMed:	A stability-indicating high performance liquid chromatographic method for the determination of diacerein in capsules.
PubMed:	Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials.
PubMed:	Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats.
PubMed:	Efficacy and safety of diacerein in early knee osteoarthritis: a randomized placebo-controlled trial.
PubMed:	Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay.
PubMed:	Anti-inflammatory and anti-peroxidative roles of diacerein are possibly mediated through an alteration in thyroid functions in animal model of inflammation.
PubMed:	Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma.
PubMed:	Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.
PubMed:	[Non-surgical treatment of osteoarthritis of large joints - new aspects].
PubMed:	Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study).
PubMed:	Physico-chemical and structural characterization of diacerhein.
PubMed:	Isolation and structural elucidation of two impurities from a diacerein bulk drug.
PubMed:	Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
PubMed:	[Treatment of osteoarthritis with drugs and other modalities].
PubMed:	In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties.
PubMed:	Bioequivalence study of two capsule formulations containing diacerein 50 mg in healthy human subjects.
PubMed:	Comment on: comparison between chondroprotective effects of glucosamine, curcumin and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.
PubMed:	An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK).
PubMed:	Clinical review of chondroitin sulfate in osteoarthritis.
PubMed:	The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
PubMed:	Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
PubMed:	In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators.
PubMed:	Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice.
PubMed:	[Effectiveness of drugs used in degenerative joint diseases (arthroses)].
PubMed:	Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.
PubMed:	Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.
PubMed:	On "Effectiveness of nonpharmacological and nonsurgical interventions..." Moe et al. Phys Ther. 2008;88: 1716-1727.
PubMed:	OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines.
PubMed:	The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period.
PubMed:	[Review of the evidence about drugs used as SYSADOA].
PubMed:	DMOAD developments: present and future.
PubMed:	Effectiveness of nonpharmacological and nonsurgical interventions for hip osteoarthritis: an umbrella review of high-quality systematic reviews.
PubMed:	Nutraceuticals in the management of osteoarthritis.
PubMed:	Direct spectrophotometric determination of diacerhein in capsules.
PubMed:	Review: diacerein is more effective than placebo and is as effective as NSAIDs for knee and hip osteoarthritis.
PubMed:	The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study.
PubMed:	Selection of reliable reference genes for qPCR studies on chondroprotective action.
PubMed:	Diacerhein versus glucosamine in a rat model of osteoarthritis.
PubMed:	A meta-analysis of controlled clinical studies with diacerein in the treatment of osteoarthritis.
PubMed:	[Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action].
PubMed:	IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein.
PubMed:	Studies in animal models of osteoarthritis as predictors of a structure-modifying effect of diacerhein in humans with osteoarthritis.
PubMed:	Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis.
PubMed:	Evaluation of efficacy and safety of diacerein in knee osteoarthritis in Chinese patients.
PubMed:	Effect of oral diacerein (DAR) in an experimental hip chondrolysis model.
PubMed:	Diacerein for osteoarthritis.
PubMed:	Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort.
PubMed:	The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
PubMed:	Chondroprotective drugs in degenerative joint diseases.
PubMed:	Heat-shock proteins and their role in chondrocyte protection, an application for autologous transplantation.
PubMed:	Osteoarthritis: an overview of the disease and its treatment strategies.
PubMed:	Tissue engineering of human cartilage and osteochondral composites using recirculation bioreactors.
PubMed:	Pharmaceutical and nutraceutical management of canine osteoarthritis: present and future perspectives.
PubMed:	Disease modification in osteoarthritis: are drugs the answer?
PubMed:	A validated HPLC stability-indicating method for the determination of diacerhein in bulk drug substance.
PubMed:	[Pharmacological treatment of osteoarthritis. Expectations and reality].
PubMed:	Future treatment of osteoarthritis.
PubMed:	Diacerein has a structure/disease-modifying effect on hip osteoarthritis.
PubMed:	Expedient total syntheses of rhein and diacerhein via Fries rearrangement.
PubMed:	Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis.
PubMed:	[Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis].
PubMed:	[Total hip arthroplasty indication, evaluation criteria for structure modifying trials. Lessons from the ECHODIAH and PHARE studies].
PubMed:	[Chondromodulation in 2003: dream or reality?].
PubMed:	Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis.
PubMed:	Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols.
PubMed:	Measurement of structure (disease) modification in osteoarthritis.
PubMed:	Determination of chromium and selected elements in multimineral and multivitamin preparations and in pharmaceutical raw material.
PubMed:	New perspectives in the management of osteoarthritis. structure modification: facts or fantasy?
PubMed:	Long-term treatment with diacerein has a structure/disease modifying effect on hip osteoarthritis.
PubMed:	Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.
PubMed:	The true results of the ECHODIAH study with diacerein.
PubMed:	[Clinical and radiographic status of patients in the ECHODIAH study who underwent THA Pertinence of the pain-function index for operative decision making].
PubMed:	[Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model].
PubMed:	[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].
PubMed:	Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects.
PubMed:	Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.
PubMed:	Oral and intra-articular remedies: Review of papers published from March 2001 to February 2002.
PubMed:	Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption.
PubMed:	In vitro study of intracellular IL-1beta production and beta1 integrins expression in stimulated chondrocytes--effect of rhein.
PubMed:	COX-1, COX-2 and articular joint disease: a role for chondroprotective agents.
PubMed:	[Current therapeutic possibilities in the treatment of arthrosis].
PubMed:	[Total hip replacement: a criterion of coxarthrosis evaluation?].
PubMed:	[Results of the ECHODIAH clinical trial on hip arthrosis].
PubMed:	[Current medical possibilities in the treatment of arthrosis].
PubMed:	Effects of diacerein on indomethacin-induced gastric ulceration.
PubMed:	Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip.
PubMed:	Innovative therapies in osteoarthritis.
PubMed:	Diacerein as a disease-modulating agent in osteoarthritis.
PubMed:	Pharmacological therapy of osteoarthritis.
PubMed:	[Case report of fatal hepatitis from diacerein].
PubMed:	Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis.
PubMed:	[Pharmacy clinics. How I treat...Osteoarthritis. 2nd part: new therapeutic perspectives].
PubMed:	The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.
PubMed:	Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
PubMed:	Reports of equivalence trials should not mask negative or mediocre results.
PubMed:	Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.
PubMed:	A novel microassay for the quantitation of the sulfated glycosaminoglycan content of histological sections: its application to determine the effects of Diacerhein on cartilage in an ovine model of osteoarthritis.
PubMed:	Pharmacologic pain treatment of musculoskeletal disorders: current perspectives and future prospects.
PubMed:	[Preclinical development of a medication: application to diacerhein].
PubMed:	Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.
PubMed:	Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis.
PubMed:	Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein.
PubMed:	Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group.
PubMed:	Synergistic antiinflammatory effect of NF-kappaB inhibitors and steroidal or non steroidal antiinflammatory drugs in the pleural inflammation induced by carrageenan in mice.
PubMed:	Effects of diacerein on biosynthesis activities of chondrocytes in culture.
PubMed:	Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
PubMed:	Effect of diacerein on spontaneous polyarthritis in male New Zealand black/KN mice.
PubMed:	Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan.
PubMed:	Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures.
PubMed:	Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1.
PubMed:	Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis.
PubMed:	[Efficacy and tolerance of diacerhein in the treatment of gonarthrosis and coxarthrosis].
PubMed:	[Evaluation of the effects of diacerhein in the sheep model of arthritis].
PubMed:	Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
PubMed:	Clinical pharmacokinetics of diacerein.
PubMed:	Diacerhein blocks iron regulatory protein activation in inflamed human monocytes.
PubMed:	[Assessment of the placebo effect of symptomatic slow-acting anti-arthritics].
PubMed:	[Functional manifestations of osteoarthritis: key points to the clinical efficacy of diacerhein].
PubMed:	Fatal toxic epidermal necrosis: responsibility of diacerein? A controversy.
PubMed:	Effects of diacerhein on granuloma induced cartilage breakdown in the mouse.
PubMed:	In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.
PubMed:	Effects of diacerhein in an accelerated canine model of osteoarthritis.
PubMed:	[Pragmatic study of diacerhein: results on clinical signs, quality of life and medico-economic costs].
PubMed:	[Effects of diacerhein on canine model with accelerated osteoarthritis].
PubMed:	[Effects of diacerhein on cytokine determinations in a model of cartilage degradation induced by granuloma in mice].
PubMed:	[Anti-interleukin-1 effects of diacerhein in vitro].
PubMed:	[Natural history of coxarthrosis: epidemiological data from the ECHODIAH study].
PubMed:	Medico-economic analysis of diacerein with or without standard therapy in the treatment of osteoarthritis.
PubMed:	Effect of diacetylrhein on the development of experimental osteoarthritis. A biochemical investigation.
PubMed:	[Acute hepatitis asociated with ingestion of of diacerein].
PubMed:	Diacerein.
PubMed:	Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation.
PubMed:	[Why pragmatic trials of the treatment of osteoarthritis? Application to the pragmatic study of diacetylrhein].
PubMed:	[Diacetylrhein administrated "curatively" in an experimental model of post-contusion osteoarthritis in rabbits].
PubMed:	[Evaluation methods of osteoarthritis: apropos of the ECHODIAH study].
PubMed:	[Study of ART 50 in daily rheumatological practice].
PubMed:	[Beneficial effects of treatment with diacerhein in guinea pigs with osteoarthritis].
PubMed:	[Molecular mechanisms implicated in the inhibition of collagenase expression by diacerheine].
PubMed:	[Severe diarrhea with hypokalemia attributed to diacetylrhein].
PubMed:	[A new drug for arthroses].
PubMed:	[Study of ART 50 in everyday rheumatic practice].
PubMed:	Diacerhein in the treatment of osteoarthritis of the hip.
PubMed:	Influence of renal function on the pharmacokinetics of diacerein after a single oral dose.
PubMed:	Pharmacokinetics of diacerein in patients with liver cirrhosis.
PubMed:	[Diacetylrhein, a new therapeutic approach of osteoarthritis].
PubMed:	[Diacetylrhein on a postcontusion model of experimental osteoarthritis in the rabbit].
PubMed:	[Effect of diacerhein (ART 50) on the matrix synthesis and collagenase secretion by cultured joint chondrocytes in rabbits].
PubMed:	Influence of renal function on the pharmacokinetics of diacerein after a single oral dose.
PubMed:	Antireactive properties of "chondroprotective" drugs.
PubMed:	[Fangotherapy and diacerein in the treatment of osteoarthrosis of the hip and knee].
PubMed:	Diacetylrhein and rhein: in vivo and in vitro effect on lymphocyte membrane fluidity.
PubMed:	Modulation of urokinase receptors on human synovial cells and osteoarthritic chondrocytes by diacetylrhein.
PubMed:	[Clinical evaluation of diacerein in the treatment of osteoarthrosis].
PubMed:	Effects of diacerein on the quantity and phagocytic activity of thioglycollate-elicited mouse peritoneal macrophages.
PubMed:	Effects of rhein on renal arachidonic acid metabolism and renal function in patients with congestive heart failure.
PubMed:	Simple method for the determination of rhein in biological fluids by high-performance liquid chromatography.
PubMed:	Effect of diacetylrhein on the phagocytosis of polymorphonuclear leucocytes and its influence on the biosynthesis of hyaluronate in synovial cells.
PubMed:	[Drug therapy of arthrosis].
PubMed:	Rhein: an anthraquinone that modulates superoxide anion production from human neutrophils.
PubMed:	[Endoscopic evaluation of the effects of diacerhein and naproxen on the gastroduodenal mucosa].
PubMed:	[Diacereine: an original approach in the treatment of degenerative and/or extra-articular rheumatism].
PubMed:	Studies in vitro on the effects of rhein on the chemotaxis of human leukocytes.
PubMed:	Experimental studies on diacerhein: effects on the phagocytosis of neutrophil cells from subcutaneous carrageenan-induced exudate.
PubMed:	[Influence of diacereine on the gastroduodenal mucosa of ulcer patients in remission and on the diuresis of cirrhosis ascites patients].
PubMed:	[Diacerein].
PubMed:	[Diacetylrhein in the treatment of degenerative arthropathies].
PubMed:	A non steroidal anti-inflammatory drug that stimulates prostaglandin release.
PubMed:	Preliminary experience with diacetylrhein in the treatment of osteoarthritis.