fenazaquin
quinazoline, 4-[2-[4-(1,1-dimethylethyl)phenyl]ethoxy]-
 
Notes:
an experimental miticide.
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CAS Number: 120928-09-8Picture of molecule3D/inchi
FDA UNII: DK5Q534WEE
Nikkaji Web: J739.230C
Beilstein Number: 8331263
MDL: MFCD01656049
XlogP3: 5.70 (est)
Molecular Weight: 306.40854000
Formula: C20 H22 N2 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 78.50 °C. @ 760.00 mm Hg
Boiling Point: 460.99 °C. @ 760.00 mm Hg (est)
Flash Point: 329.00 °F. TCC ( 165.10 °C. ) (est)
logP (o/w): 5.510
Soluble in:
 water, 0.2219 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Fenazaquin
Sigma-Aldrich
For experimental / research use only.
Fenazaquin PESTANAL®, analytical standard
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  1789 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. OTS0543587

oral-quail LD50  > 2000 mg/kg
Pesticide Manual. Vol. 9, Pg. 363, 1991.

oral-rat LD50  136 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. OTS0543600

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LD50 1820 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0543610

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Safety in Use Information:
Category: herbicides / pesticides
Recommendation for fenazaquin usage levels up to:
 not for fragrance use.
 
Recommendation for fenazaquin flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Conclusion on the peer review of the pesticide risk assessment of the active substance fenazaquin
View page or View pdf
Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
Setting of an import tolerance for fenazaquin in almonds
View page or View pdf
Review of the existing maximum residue levels for fenazaquin according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 86356
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline
Chemidplus: 0120928098
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References:
 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 86356
Pubchem (sid): 135043591
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C18727
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Formulations/Preparations:
•emulsifiable concentrate; suspension concentrate. •fenazaquin technical (gowan company, llc) fenazaquin 99.4% •gwn-1708 miticideinsecticide (gowan company, llc) fenazaquin 18.79%
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
4-tert-butylphenethyl quinazolin-4-yl ether
4-tert-butylphenethylquinazolin-4-yl ether
4-[2-(4-tert-butylphenyl)ethoxy]quinazoline
4-[2-[4-(1,1-dimethylethyl)phenyl]ethoxy]quinazoline
4-{2-[4-(2-methyl-2-propanyl)phenyl]ethoxy}quinazoline
 quinazoline, 4-[2-[4-(1,1-dimethylethyl)phenyl]ethoxy]-
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Articles:
PubMed: Acaricide resistance in Tetranychus urticae (Acari: Tetranychidae) populations from Cyprus.
PubMed: Degradation studies of fenazaquin in soil under field and laboratory conditions.
PubMed: DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity.
PubMed: Evaluation of the efficacy of Oberon (Spiromesifen), to contain infestations of mites and whiteflies on Capsicum annuum L.
PubMed: Evaluation of the efficacy and selectivity of Oberon (Spiromesifen) for the control of Tetranychus urticae on strawberry.
PubMed: Multi-residue analysis of 30 currently used pesticides in fine airborne particulate matter (PM 2.5) by microwave-assisted extraction and liquid chromatography-tandem mass spectrometry.
PubMed: Effect of household processing on fenazaquin residues in okra fruits.
PubMed: Pesticide extraction from table grapes and plums using ionic liquid based dispersive liquid-liquid microextraction.
PubMed: Ionic liquid based dispersive liquid-liquid microextraction for the extraction of pesticides from bananas.
PubMed: Antimutagenic and antigenotoxic effects of vegetable matrices on the activity of pesticides.
PubMed: Exposure to pesticides residues from consumption of Italian blood oranges.
PubMed: Side-effects of fenazaquin on a cellular model of Paramecium.
PubMed: Application of hollow fibre liquid phase microextraction for the multiresidue determination of pesticides in alcoholic beverages by ultra-high pressure liquid chromatography coupled to tandem mass spectrometry.
PubMed: Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae).
PubMed: Efficacy of five selected acaricides against Tetranychus urticae (Acari: Tetranychidae) and their side effects on relevant natural enemies occurring in citrus orchards.
PubMed: Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease.
PubMed: Multiple resistance and biochemical mechanisms of pyridaben resistance in Tetranychus urticae (Acari: Tetranychidae).
PubMed: Investigation in tea on fate of fenazaquin residue and its transfer in brew.
PubMed: Metabolism of fenazaquin, an acaricide in tea plant.
PubMed: Fenpyroximate resistance in Tetranychus urticae (Acari: Tetranychidae): cross-resistance and biochemical resistance mechanisms.
PubMed: Application of liquid chromatography with electrospray tandem mass spectrometry to the determination of a new generation of pesticides in processed fruits and vegetables.
PubMed: Investigation in tea on fate of fenazaquin residue and its transfer in brew.
PubMed: Photodecomposition of an acaricide, fenazaquin, in aqueous alcoholic solution.
PubMed: Synthesis and fungicidal activity of a series of novel aryloxylepidines.
PubMed: Incidence and inheritance of resistance to METI-acaricides in European strains of the two-spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae).
PubMed: Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).
PubMed: NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells.
PubMed: Regulatory implications of peroxisome proliferation: an industrial perspective.
PubMed: Insecticidal quinazoline derivatives with (trifluoromethyl)diazirinyl and azido substituents as NADH:ubiquinone oxidoreductase inhibitors and candidate photoaffinity probes.
PubMed: Use of vancomycin hydrochloride for treatment of Clostridium difficile enteritis in Syrian hamsters.
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