tocopheryl phosphate
 
Notes:
None found
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CAS Number: 425429-22-7 
Category: emulsifiers, surfactants
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: cleansing agents
emulsifying agents
hair conditioning
surfactants
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for tocopheryl phosphate usage levels up to:
 not for fragrance use.
 
Recommendation for tocopheryl phosphate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
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References:
Pubchem (cas): 425429-22-7
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Other Information:
HMDB (The Human Metabolome Database): Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 tocopheryl phosphate
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Articles:
PubMed: Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed: Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure.
PubMed: The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism.
PubMed: Induction of VEGF expression by alpha-tocopherol and alpha-tocopheryl phosphate via PI3Kγ/PKB and hTAP1/SEC14L2-mediated lipid exchange.
PubMed: α-Tocopheryl Phosphate as a Bioactive Derivative of Vitamin E: A Review of the Literature.
PubMed: Modulation of phosphorylation of tocopherol and phosphatidylinositol by hTAP1/SEC14L2-mediated lipid exchange.
PubMed: α-Tocopheryl-phosphate regulation of gene expression in preadipocytes and adipocytes.
PubMed: The vitamin E derivative, EPC-K1, suppresses inflammation during hepatic ischemia-reperfusion injury and exerts hepatoprotective effects in rats.
PubMed: α-Tocopheryl phosphate--an activated form of vitamin E important for angiogenesis and vasculogenesis?
PubMed: α-tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.
PubMed: The antioxidant EPC-K1 attenuates renal ischemia-reperfusion injury in a rat model.
PubMed: α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse.
PubMed: Modulation of gene expression by α-tocopherol and α-tocopheryl phosphate in THP-1 monocytes.
PubMed: Importance of EPC-K1 in ischemia and reperfusion injury.
PubMed: alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells.
PubMed: alpha-Tocopheryl phosphate--an active lipid mediator?
PubMed: Vitamin E and cancer.
PubMed: alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression.
PubMed: Effect of tocopheryl phosphate on key biomarkers of inflammation: Implication in the reduction of atherosclerosis progression in a hypercholesterolaemic rabbit model.
PubMed: alpha-tocopheryl phosphate suppresses tumor invasion concurrently with dynamic morphological changes and delocalization of cortactin from invadopodia.
PubMed: Inhibitory effect of antioxidants on hydroxyl radical generation from methylguanidine: an ESR study.
PubMed: Cardioprotection with alpha-tocopheryl phosphate: amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation.
PubMed: Modulation of proteasome activity by vitamin E in THP-1 monocytes.
PubMed: Comparison of nitric oxide synthase inhibitors, phospholipase A2 inhibitor and free radical scavengers as attenuators of opioid withdrawal syndrome.
PubMed: Differential effects of the ascorbyl and tocopheryl derivative on the methamphetamine-induced toxic behavior and toxicity.
PubMed: Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention.
PubMed: Molecular mechanism of alpha-tocopheryl-phosphate transport across the cell membrane.
PubMed: Molecular and cellular activities of vitamin E analogues.
PubMed: Alpha-tocopheryl phosphate is a novel apoptotic agent.
PubMed: The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet.
PubMed: Evaluation of the safety of mixed tocopheryl phosphates (MTP) -- a formulation of alpha-tocopheryl phosphate plus alpha-di-tocopheryl phosphate.
PubMed: Alpha-tocopheryl phosphate: a novel, natural form of vitamin E.
PubMed: On the existence of cellular tocopheryl phosphate, its synthesis, degradation and cellular roles: a hypothesis.
PubMed: Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation.
PubMed: The therapeutic role of taurine in ischaemia-reperfusion injury.
PubMed: Dentin is dissolved by high concentrations of L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl-hydrogen phosphate] potassium salt with or without hydrogen peroxide.
PubMed: Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation.
PubMed: A novel antioxidant, EPC-K1, stimulates endothelial nitric oxide production and scavenges hydroxyl radicals.
PubMed: The antioxidant EPC-K1 ameliorates brain injury by inhibiting lipid peroxidation in a rat model of transient focal cerebral ischaemia.
PubMed: Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed: EPC-K1 reduces the expression of inducible nitric oxide synthase (iNOS) in delayed neuronal death (DND).
PubMed: Effects of a hydroxyl radical scavenger, EPC-K1, and neutrophil depletion on reperfusion injury in rat skeletal muscle.
PubMed: Attenuation of oxidative DNA damage with a novel antioxidant EPC-K1 in rat brain neuronal cells after transient middle cerebral artery occlusion.
PubMed: Combination of a free radical scavenger and heparin reduces cerebral hemorrhage after heparin treatment in a rabbit middle cerebral artery occlusion model.
PubMed: Nitric oxide induces oxidative stress and apoptosis in neuronal cells.
PubMed: Novel approach to in vivo screening for radioprotective activity in whole mice: in vivo electron spin resonance study probing the redox reaction of nitroxyl.
PubMed: Characterization of the activity of L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-be nzopyran-6-yl-hydrogen phosphate] potassium salt in hydroxyl radical elimination.
PubMed: Effects of EPC-K1 on lipid peroxidation in experimental spinal cord injury.
PubMed: EPC-K1, a hydroxyl radical scavenger, prevents 6-hydroxydopamine-induced dopamine depletion in the mouse striatum by up-regulation of catalase activity.
PubMed: Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver.
PubMed: The antioxidant EPC-K1 attenuates NO-induced mitochondrial dysfunction, lipid peroxidation and apoptosis in cerebellar granule cells.
PubMed: Reduced reperfusion injury in muscle. A comparison of the timing of EPC-K1 administration in rats.
PubMed: Antioxidant properties of EPC-K1: a study on mechanisms.
PubMed: EPC-K1 attenuates peroxynitrite-induced apoptosis in cerebellar granule cells.
PubMed: Hydroxyl radical generation after the third hour following ischemia contributes to brain damage.
PubMed: Restoration of the glucocorticoid receptor function by the phosphodiester compound of vitamins C and E, EPC-K1 (L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl hydrogen phosphate] potassium salt), via a redox-dependent mechanism.
PubMed: Inhibition of NF-kappaB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1.
PubMed: Effect of EPC-K1 on myocardial infarct size in a rat model with coronary artery occlusion and reperfusion.
PubMed: Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach.
PubMed: Reduced ischemia-reperfusion injury in muscle. Experiments in rats with EPC-K1, a new radical scavenger.
PubMed: The effect of combination therapy with EPC-K1 and low-dose cyclosporine to pulmonary allograft after rat lung transplantation.
PubMed: [Effect of phosphate diester linkage of vitamin E and vitamin C (EPC-K1) on myocardial ischemia reperfusion injury in the isolated working rat heart].
PubMed: EPC-K1 is effective in lung preservation in an ex vivo rabbit lung perfusion model.
PubMed: Hepatropic soluble vitamin E derivative EPC-K1 prevents warm ischemia/reperfusion injury of non-heart-beating donor liver transplantation in pigs.
PubMed: Enhancing effect of thoraco-laparotomy on liver metastasis and the role played by active oxygens in its mechanism.
PubMed: Inhibitory effects of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) on myocardial infarction in rats.
PubMed: Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats.
PubMed: Effects of L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6yl-hydrogen phosphate] potassium salt on cerebral energy state and consciousness recovery following transient forebrain ischemia in gerbils.
PubMed: [Stability studies on L-ascorbic acid dl-alpha-tocopherol phosphoric acid diester potassium salt (EPC-K)].
PubMed: Cytoprotective effect of tocopherols in hepatocytes cultured with polyunsaturated fatty acids.
PubMed: Beneficial effect of EPC-K1 on the survival of warm ischemic damaged graft in rat cardiac transplantation.
PubMed: [Effectiveness of various pharmaceutical forms of alfa-tocopherol].
PubMed: [Comparison of the effectiveness of oil and water solutions of alpha-tocopherol as radiation protection agent].
PubMed: Determination of pipamperone in human plasma by high performance liquid chromatography.
PubMed: A newly developed hydroxyl radical scavenger, EPC-K1 can improve the survival of swine warm ischemia-damaged transplanted liver grafts.
PubMed: [Phosphocreatine, tocopheryl phosphate and their combination in acute ischemia and myocardial reperfusion in dogs: the effect on rhythm disorders, left ventricle contractility and infarct size].
PubMed: Effect of ferric ion and active oxygen scavenger on monoamine release in the striatum of the rat.
PubMed: [The effect of alpha-tocopherol in water-soluble form on human erythrocyte membranes while in contact with oxygen].
PubMed: [Improving the contractility and metabolism of the isolated rat heart during post-ischemia reperfusion with phosphocreatine, tocopheryl phosphate and their combination].
PubMed: [Mechanisms of the conduction of cellular regulatory signals].
PubMed: Increased activity of cyclic AMP phosphodiesterase from frozen-thawed rat liver. A role of lysosomal protease in enzyme activation.
PubMed: [Effect of alpha-tocopheryl phosphate (alpha-TPh) on D-amino acid oxidase and aminoxidase of rat liver homogenates].
PubMed: [The effect of alpha-tocopheryl phosphate (alpha-TPh) on aminoxidase of normal rat diaphragm].
PubMed: On the mechanism of action of alpha-tocopheryl phosphate, with special reference to carbohydrate metabolism of striated muscle. III. Inhibition of insulin-induced glycogenesis in isolated rat diaphragm.
PubMed: On the mechanism of action of alpha-tocopheryl phosphate, with special reference to carbohydrate metabolism of striated muscle. II. Effect on the capacity of rat diaphragm to dissimilate hexose phosphates.
PubMed: On the mechanism of action of alpha-tocopheryl phosphate, with special reference to carbohydrate metabolism of striated muscle. I. Modification of epinephrine effect, hyperlactacidemia, by alpha-tocopheryl phosphate in the rat.
PubMed: [Results with tocopheryl phosphate and inositol therapy of Erb's progressive muscular dystrophy].
PubMed: Effect of alpha-tocopheryl phosphate on enzyme activity.
PubMed: The locus of action of alpha-tocopheryl phosphate in the succinoxidase system.
PubMed: The effect of alpha-tocopheryl phosphate on the inhibition of phosphatase by estrogens in vitro.
PubMed: On the antithrombic and antiproteolytic activity of alpha tocopheryl phosphate.
PubMed: The Effect of agr-Tocopheryl Phosphate on Diphosphopyridine Nucleotidase.
PubMed: Effect of calcium on the inhibition of the succinic oxidase system by d-alpha-tocopheryl phosphate.
PubMed: Effect of calcium on the inhibition of the succinic oxidase system by delta-tocopheryl phosphate.
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