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Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 207.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 430.00 to 431.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 417.00 °F. TCC ( 214.00 °C. ) (est)
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| logP (o/w): | -0.661 (est) |
| Soluble in: |
| | water, 2.567e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | special dietary and nutritional additives |
| Recommendation for laevo-theanine usage levels up to: | | | not for fragrance use.
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| Recommendation for laevo-theanine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2S)-2-2S)-2- | amino-4-(N-ethylcarbamoyl)butanoic acid | | (2S)-2- | amino-5-(ethylamino)-5-oxopentanoic acid | | (S)-2- | amino-5-(ethylamino)-5-oxopentanoic acid | | N- | ethyl-L-glutamine | | N- | ethyl-laevo-glutamine | | L- | glutamine, N-ethyl- | | | suntheanine | | L- | theanine |
Articles:
| PubMed: | Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double-blind, placebo-controlled trial. |
| J-Stage: | The Involvement of L-Type Amino Acid Transporters in Theanine Transport |
| PubMed: | L-Theanin, Unique Aminoacid of Tea, and Its Metabolism, Health Effects, Safety. |
| PubMed: | Protective Effect of L-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway. |
| PubMed: | Quantification of total polyphenols, catechin, caffeine, L-theanine, determination of antioxidant activity and effect on antileishmanial drugs of ethiopian tea leaves extracts. |
| PubMed: | Fast Dissolving/Disintegrating Dosage Forms: Growth from Immediate Release to Sustained Release and Traditional Medicines. |
| PubMed: | Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration? |
| PubMed: | Epigallocatechin-3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFα-stimulated human endothelial cells. |
| PubMed: | Effect of l-theanine on glutamatergic function in patients with schizophrenia. |
| PubMed: | An overview of biological production of L-theanine. |
| PubMed: | l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor. |
| PubMed: | A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. |
| PubMed: | In Search of a Safe Natural Sleep Aid. |
| PubMed: | Tea (Camellia Sinensis (L.)): a Putative Anticancer Agent in Bladder Carcinoma? |
| PubMed: | Tea (Camellia sinensis (L.)): a putative anticancer agent in bladder carcinoma? |
| PubMed: | Investigational drugs for anxiety in patients with schizophrenia. |
| PubMed: | Acute effects of dietary constituents on motor skill and cognitive performance in athletes. |
| PubMed: | L-theanine synthesis using γ-glutamyl transpeptidase from Bacillus licheniformis ER-15. |
| PubMed: | Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression. |
| PubMed: | Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives. |
| PubMed: | L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin. |
| PubMed: | Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. |
| PubMed: | Mitochondrial toxic effects of Aβ through mitofusins in the early pathogenesis of Alzheimer's disease. |
| PubMed: | Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain - histopathological, and biochemical approach. |
| PubMed: | L-Theanine elicits umami taste via the T1R1 + T1R3 umami taste receptor. |
| PubMed: | Identifying key non-volatile compounds in ready-to-drink green tea and their impact on taste profile. |
| PubMed: | Effect of L-theanine on sensorimotor gating in healthy human subjects. |
| PubMed: | Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum. |
| PubMed: | L-theanine (suntheanin): effects of L-theanine, an amino acid derived from Camellia sinensis (green tea), on stress response parameters. |
| PubMed: | Physiological effects of L-theanine on Drosophila melanogaster. |
| PubMed: | To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder. |
| PubMed: | Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action. |
| PubMed: | Electron paramagnetic resonance studies of gamma-irradiated DL-alanine ethyl ester hydrochloride, L-theanine and L-glutamic acid dimethyl ester hydrochloride. |
| PubMed: | Effect of electrolyzed reduced water on chiral theanine and polyphenols in tea. |
| PubMed: | Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. |
| PubMed: | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. |
| PubMed: | L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway. |
| PubMed: | The involvement of L-type amino acid transporters in theanine transport. |
| PubMed: | [Mechanisms of cerebral protection from ischemia by tea constituents]. |
| PubMed: | Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. |
| PubMed: | L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. |
| PubMed: | Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea. |
| PubMed: | l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice. |
| PubMed: | Rapid and selective quantification of L-theanine in ready-to-drink teas from Chinese market using SPE and UPLC-UV. |
| PubMed: | L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation. |
| PubMed: | Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice. |
| PubMed: | L-Theanine extends lifespan of adult Caenorhabditis elegans. |
| PubMed: | Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. |
| PubMed: | L-theanine partially counteracts caffeine-induced sleep disturbances in rats. |
| PubMed: | [Raman spectral analysis of theanine]. |
| PubMed: | Tea and cognitive health in late life: current evidence and future directions. |
| PubMed: | The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. |
| PubMed: | Nerve and behavioral responses of mice to various umami substances. |
| PubMed: | l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes. |
| PubMed: | Behavioral and molecular evidence for psychotropic effects in L-theanine. |
| PubMed: | Optimum conditions for the water extraction of L-theanine from green tea. |
| PubMed: | L-Theanine: properties, synthesis and isolation from tea. |
| PubMed: | Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients. |
| PubMed: | Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice. |
| PubMed: | Production of bioactive γ-glutamyl transpeptidase in Escherichia coli using SUMO fusion partner and application of the recombinant enzyme to L-theanine synthesis. |
| PubMed: | A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. |
| PubMed: | L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. |
| PubMed: | A randomized targeted amino acid therapy with behaviourally at-risk adopted children. |
| PubMed: | The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. |
| PubMed: | L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. |
| PubMed: | Anxiolytic effects of L-theanine--a component of green tea--when combined with midazolam, in the male Sprague-Dawley rat. |
| PubMed: | L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. |
| PubMed: | Effects of (L)-cystine and (L)-theanine supplementation on the common cold: a randomized, double-blind, and placebo-controlled trial. |
| PubMed: | Neuroprotection by radical avoidance: search for suitable agents. |
| PubMed: | Combined administration of (L)-cystine and (L)-theanine enhances immune functions and protects against influenza virus infection in aged mice. |
| PubMed: | l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways. |
| PubMed: | Impact of two types of Internet-based information on medical students' performance in an Objective Structured Clinical Exam (OSCE). |
| PubMed: | Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. |
| PubMed: | Tea and health: preventive and therapeutic usefulness in the elderly? |
| PubMed: | L-theanine elicits an umami taste with inosine 5'-monophosphate. |
| PubMed: | The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. |
| PubMed: | The combined effects of L-theanine and caffeine on cognitive performance and mood. |
| PubMed: | L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. |
| PubMed: | L-theanine, a natural constituent in tea, and its effect on mental state. |
| PubMed: | Immobilization of Escherichia coli novablue gamma-glutamyltranspeptidase in Ca-alginate-kappa-carrageenan beads. |
| PubMed: | Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. |
| PubMed: | Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells. |
| PubMed: | L-theanine intervention enhances human gammadeltaT lymphocyte function. |
| PubMed: | Psychological effects of dietary components of tea: caffeine and L-theanine. |
| PubMed: | Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine. |
| PubMed: | [Separation and quantification of theanine enantiomers using high performance liquid chromatography coupled with chiral derivatization]. |
| PubMed: | Bioactive food components that enhance gammadelta T cell function may play a role in cancer prevention. |
| PubMed: | Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin. |
| PubMed: | The effects of L-theanine, caffeine and their combination on cognition and mood. |
| PubMed: | Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: II. Characterization in the freely moving rat by means of quantitative field potential analysis. |
| PubMed: | Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: I. electrophysiological characterization in the rat hippocampus in-vitro. |
| PubMed: | Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. |
| PubMed: | The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. |
| PubMed: | Expression optimization and biochemical characterization of a recombinant gamma-glutamyltranspeptidase from Escherichia coli novablue. |
| PubMed: | Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. |
| PubMed: | L-Theanine reduces psychological and physiological stress responses. |
| PubMed: | A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats. |
| PubMed: | Molecular and sensory studies on the umami taste of Japanese green tea. |
| PubMed: | L-theanine . Monograph. |
| PubMed: | Pharmacokinetics of theanine enantiomers in rats. |
| PubMed: | The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. |
| PubMed: | Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry. |
| PubMed: | Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. |
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