silybum marianum seed extract
extract of the seeds of the lady's thistle, silybum marianum (l.), asteraceae
 
Notes:
None found
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Name: silybum marianum l. seed extract
CAS Number: 84604-20-6 
ECHA EC Number: 283-298-7
Category: cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
AuNutra® Industries
Milk Thistle Seed P.E
Bio-Botanica®
Milk Thistle Seed Silybum Marianum Seed Extract
Bio-Botanica®
Milk Thistle, AF – 5510
Bio-Botanica®
Milk Thistle, FE – 5090D
Bristol Botanicals
Milk Thistle seed fluid extract Carduus marianus 1:1 50%
Dongguan Meiherb Biotech
Milk Thistle Extract
Odor: characteristic
Use: Milk Thistle extract is prepared from the milk thistle, a plant that belongs to the sunflower family, which has been revered for thousands of years as an effective healing herb. Milk Thistle extract is popular in Europe and the United States as it is used for various types of liver diseases. It is also used for viral hepatitis, acute and chronic hepatitis, cirrhosis, fatty liver, nutritional and metabolic disease and cardiovascular disease.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  681 mg/kg
Indian Journal of Experimental Biology. Vol. 22, Pg. 487, 1984.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for silybum marianum seed extract usage levels up to:
 not for fragrance use.
 
Recommendation for silybum marianum seed extract flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
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AIDS Citations: Search
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 silybum marianum l. seed extract
Chemidplus: 0084604206
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References:
 silybum marianum l. seed extract
Pubchem (sid): 135252480
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Other Information:
MedlinePlusSupp: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 milk thistle seed
Search Trop  Picture
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Synonyms:
 extract of the seeds of the lady's thistle, silybum marianum (l.), asteraceae
lady's thistle seed extract
ladys thistle seed extract
milk thistle seed extract
st. mary's thistle seed extract
st. marys thistle seed extract
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Articles:
PubMed: Synergistic effects of drought stress and photoperiods on phenology and secondary metabolism of Silybum marianum.
PubMed: Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil.
PubMed: Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage.
PubMed: Screening for soil streptomycetes from North Jordan that can produce herbicidal compounds.
PubMed: Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury.
PubMed: Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.
PubMed: The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants.
PubMed: Pretreatment of milk thistle seed to increase the silymarin yield: an alternative to petroleum ether defatting.
PubMed: [Formation of flavanolignane in the white-flowered variety (Szibilla) of Silybum marianum in relation to fruit development].
PubMed: Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process.
PubMed: The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial.
PubMed: Variability pattern and correlation studies in Silybum marianum Gaertn.
PubMed: Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner).
PubMed: Silymarin, a possible hepatoprotector in dairy cows: biochemical and histological observations.
PubMed: Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus.
PubMed: Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents.
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