osteopontin
2ar peptide
 
Notes:
None found
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CAS Number: 106441-73-0 
Category: special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 716 Bovine milk osteopontin View - notice PDF
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Sigma-Aldrich: Sigma
For experimental / research use only.
Osteopontin human recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE), ≥97% (HPLC), cell culture tested
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for osteopontin usage levels up to:
 not for fragrance use.
 
Recommendation for osteopontin flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0106441730
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References:
Pubchem (sid): 135329030
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Other Information:
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 2ar peptide
 44 kda phosphoprotein
 bone sialoprotein I
 eta-1 protein
bovine milk osteopontin
 phosphoprotein I, 2aR
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Articles:
PubMed: Pre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan® OPN-10.
PubMed: Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse.
PubMed: Seminal plasma proteome of electroejaculated Bos indicus bulls.
PubMed: Stimulation of Osteogenic Activity in Human Osteoblast Cells by Edible Uraria crinita.
PubMed: Age-related differences in kidney injury biomarkers induced by cisplatin.
PubMed: Effect of Sleeve Gastrectomy on Osteopontin Circulating Levels and Expression in Adipose Tissue and Liver in Rats.
PubMed: Increased blood-circulating interferon-γ, interleukin-17, and osteopontin levels in bovine paratuberculosis.
PubMed: Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers.
PubMed: Collagen hydrolysates increased osteogenic gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts.
PubMed: An exploratory evaluation of the utility of transcriptional and urinary kidney injury biomarkers for the prediction of aristolochic acid-induced renal injury in male rats.
PubMed: Unraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 years.
PubMed: Serum osteopontin concentration is decreased by exercise-induced fat loss but is not correlated with body fat percentage in obese humans.
PubMed: Change in kidney damage biomarkers after 13 weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae.
PubMed: Effects of sodium citrate on melamine-cyanuric acid mixture-induced urolithiasis in rats.
PubMed: Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns.
PubMed: 12 weeks' aerobic and resistance training without dietary intervention did not influence oxidative stress but aerobic training decreased atherogenic index in middle-aged men with impaired glucose regulation.
PubMed: Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health.
PubMed: Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media.
PubMed: Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.
PubMed: Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats.
PubMed: Differential effects of high-fat-diet rich in lard oil or soybean oil on osteopontin expression and inflammation of adipose tissue in diet-induced obese rats.
PubMed: Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.
PubMed: Osteopontin is involved in estrogen-mediated protection against diethylnitrosamine-induced liver injury in mice.
PubMed: Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370.
PubMed: Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials.
PubMed: Differentiation of osteoprogenitor cells is induced by high-frequency pulsed electromagnetic fields.
PubMed: Biological activities of glucosamine and its related substances.
PubMed: Proteomic analysis and immunodetection of the bovine milk osteopontin isoforms.
PubMed: Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat.
PubMed: Hepatic endothelin-1 and endocannabinoids-dependent effects of hyperleptinemia in nonalcoholic steatohepatitis-cirrhotic rats.
PubMed: Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats.
PubMed: Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells.
PubMed: Effects of water uptake on melamine renal stone formation in mice.
PubMed: A Prunus mume extract stimulated the proliferation and differentiation of osteoblastic MC3T3-E1 cells.
PubMed: Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro.
PubMed: Renal glomerular and tubular injury after gastric bypass in obese rats.
PubMed: Male reproductive traits and their relationship to reproductive traits in their female progeny: a systematic review.
PubMed: Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells.
PubMed: Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats.
PubMed: Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats.
PubMed: Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach.
PubMed: Comparative studies on bone structure in dairy cows with different feeding conditions.
PubMed: Mass spectrometry and renal calculi.
PubMed: Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs.
PubMed: Protective effects of bovine colostrum acid proteins on bone loss of ovariectomized rats and the ingredients identification.
PubMed: Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals.
PubMed: Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells.
PubMed: Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.
PubMed: Evaluation of subchronic toxicity of pet food contaminated with melamine and cyanuric acid in rats.
PubMed: Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis.
PubMed: Seminal plasma proteins as potential markers of relative fertility in boars.
PubMed: Calcium transport in strongly calcifying laying birds: mechanisms and regulation.
PubMed: Preventive effects of nutritional doses of polyphenolic molecules on cardiac fibrosis associated with metabolic syndrome: involvement of osteopontin and oxidative stress.
PubMed: The effect of weight loading and subsequent release from loading on the postnatal skeleton.
PubMed: Aberrant expression of retinol-binding protein, osteopontin and fibroblast growth factor 7 in the porcine uterine endometrium of pregnant recipients carrying embryos produced by somatic cell nuclear transfer.
PubMed: Osteoblast differentiation and bone formation gene expression in strontium-inducing bone marrow mesenchymal stem cell.
PubMed: Effects of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester application.
PubMed: Inhibitory activity of bovine milk osteopontin and its fragments on the formation of calcium phosphate precipitates.
PubMed: Structural features of incremental line-like striations in mandibular condylar cartilage of c-src-deficient mice.
PubMed: Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects.
PubMed: Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats.
PubMed: The effect of vitamin K2 on bone metabolism in aged female rats.
PubMed: Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation.
PubMed: Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice.
PubMed: The effect of altered functional forces on the expression of bone-matrix proteins in developing mouse mandibular condyle.
PubMed: Vitamin A and carotenoids stimulate differentiation of mouse osteoblastic cells.
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