huperzine A, 102518-79-6

Articles:

PubMed:	Biotransformation of Huperzine A by a Fungal Endophyte of Huperzia serrata Furnished Sesquiterpenoid-Alkaloid Hybrids.
PubMed:	Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A.
PubMed:	[Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors].
PubMed:	Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer's Disease?
PubMed:	Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
PubMed:	Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus.
PubMed:	The neurovascular protective effects of huperzine a on d-galactose-induced inflammatory damage in the rat hippocampus.
PubMed:	The protective effect of huperzine A against hepatic ischemia reperfusion injury in mice.
PubMed:	Cholinesterase Inhibition in Alzheimer's Disease: Is Specificity the Answer?
PubMed:	Design, synthesis, and evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors.
PubMed:	Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways.
PubMed:	Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.
PubMed:	Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.
PubMed:	Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
PubMed:	Marine natural products as acetylcholinesterase inhibitor: comparative quantum mechanics and molecular docking study.
PubMed:	A novel approach to medical countermeasures against organophosphorus compound toxicity.
PubMed:	Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis.
PubMed:	A new role for the nonpathogenic nonsynonymous single-nucleotide polymorphisms of acetylcholinesterase in the treatment of Alzheimer's disease: a computational study.
PubMed:	Whole-Genome Shotgun Assembly and Analysis of the Genome of Shiraia sp. Strain Slf14, a Novel Endophytic Fungus Producing Huperzine A and Hypocrellin A.
PubMed:	Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins.
PubMed:	Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
PubMed:	Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.
PubMed:	Synergistic Effect and Mechanism of Cineole and Terpineol on In-vitro Transdermal Delivery of Huperzine A from Microemulsions.
PubMed:	Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease.
PubMed:	Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms.
PubMed:	Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata.
PubMed:	Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials.
PubMed:	Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain.
PubMed:	Huperzine A inhibits CCL2 production in experimental autoimmune encephalomyelitis mice and in cultured astrocyte.
PubMed:	[Effect of PNS on the activity and content of BACE1 in the brain of SAMP8 mice with Alzheimer's disease].
PubMed:	Current acetylcholinesterase-inhibitors: a neuroinformatics perspective.
PubMed:	Controlled iontophoretic transport of huperzine A across skin in vitro and in vivo: effect of delivery conditions and comparison of pharmacokinetic models.
PubMed:	[Effect of litchi seed aqueous extracts on learning and memory obstacles induced by D-galactose in mice and its mechanism].
PubMed:	[Determination of huperzine A and semi-quantitative RT-PCR analysis of lysine decarboxylase gene in different parts of Huperzia serrata from western Hunan].
PubMed:	Natural products as sources of new lead compounds for the treatment of Alzheimer's disease.
PubMed:	Study of the interaction of Huperzia saururus Lycopodium alkaloids with the acetylcholinesterase enzyme.
PubMed:	The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
PubMed:	[Effect of Huperzine A on neural lesion of acute organophosphate poisoning in mice].
PubMed:	[Determination of Huperzine A in the extract of Huperzia serrata by high performance liquid chromatography].
PubMed:	[The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer's disease].
PubMed:	Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease.
PubMed:	The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain.
PubMed:	Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026.
PubMed:	Eleutheroside B or E enhances learning and memory in experimentally aged rats.
PubMed:	Integrative proteomics.
PubMed:	Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert.
PubMed:	Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
PubMed:	Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.
PubMed:	Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.
PubMed:	Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells.
PubMed:	Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A.
PubMed:	Multitarget drugs of plants origin acting on Alzheimer's disease.
PubMed:	The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice.
PubMed:	Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures.
PubMed:	[Effect and mechanism of dingzhixiao wan on scopolamine-induced learning-memory impairment in mice].
PubMed:	Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
PubMed:	Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A.
PubMed:	A novel synthesis of (-)-huperzine A via tandem intramolecular aza-Prins cyclization-cyclobutane fragmentation.
PubMed:	Transepithelial transport of a natural cholinesterase inhibitor, huperzine A, along the gastrointestinal tract: the role of ionization on absorption mechanism.
PubMed:	Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam.
PubMed:	New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease.
PubMed:	The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats.
PubMed:	Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro.
PubMed:	Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
PubMed:	Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.
PubMed:	Huperzine A for mild cognitive impairment.
PubMed:	Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.
PubMed:	Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart.
PubMed:	[Effect of Panax notoginseng saponins on expression of alpha-secretase mRNA in brains of senescence-accelerated SAMP8 mice].
PubMed:	A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
PubMed:	The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells.
PubMed:	Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.
PubMed:	Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain.
PubMed:	New insights into huperzine A for the treatment of Alzheimer's disease.
PubMed:	On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis.
PubMed:	Molecular cloning and characterization of copper amine oxidase from Huperzia serrata.
PubMed:	An efficient total synthesis of (-)-huperzine A.
PubMed:	Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
PubMed:	Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors.
PubMed:	Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
PubMed:	Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).
PubMed:	Examining the interactome of huperzine A by magnetic biopanning.
PubMed:	Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release.
PubMed:	Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.
PubMed:	Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.
PubMed:	Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice.
PubMed:	Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
PubMed:	Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
PubMed:	Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia.
PubMed:	Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations.
PubMed:	Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
PubMed:	Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.
PubMed:	Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
PubMed:	Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
PubMed:	Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.
PubMed:	Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.
PubMed:	Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets.
PubMed:	Treatment with Huperzine A improves cognition in vascular dementia patients.
PubMed:	[+]-Huperzine A protects against soman toxicity in guinea pigs.
PubMed:	Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies.
PubMed:	An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production.
PubMed:	Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
PubMed:	The role of phytochemicals in the treatment and prevention of dementia.
PubMed:	Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation.
PubMed:	A phase II trial of huperzine A in mild to moderate Alzheimer disease.
PubMed:	Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.
PubMed:	Preventing H₂O₂-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone.
PubMed:	Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.
PubMed:	The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
PubMed:	[Analysis of dynamic change of huperzine A content in Huperzia serrata].
PubMed:	Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners.
PubMed:	Modification and validation of a high-performance liquid chromatography method for quantification of Huperzine A in Huperzia crispata.
PubMed:	Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.
PubMed:	Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors.
PubMed:	Pharmacological agents in the prophylaxis/treatment of organophosphorous pesticide intoxication.
PubMed:	Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation.
PubMed:	Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method.
PubMed:	Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius.
PubMed:	Huperzine alkaloids from Australasian and southeast Asian Huperzia.
PubMed:	Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice.
PubMed:	Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
PubMed:	A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata.
PubMed:	Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
PubMed:	Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.
PubMed:	Analysis of expressed sequence tags from the Huperzia serrata leaf for gene discovery in the areas of secondary metabolite biosynthesis and development regulation.
PubMed:	AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion.
PubMed:	Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.
PubMed:	Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre.
PubMed:	[Research advances of Huperzia serrata (Thunb.) Trev].
PubMed:	Detection by UPLC/ESI-TOF-MS of alkaloids in three Lycopodiaceae species from French Polynesia and their anticholinesterase activity.
PubMed:	Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
PubMed:	[Release mechanism of huperzine-A swelling sustained-release tablets].
PubMed:	Total synthesis of (-)-huperzine A.
PubMed:	Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.
PubMed:	Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats.
PubMed:	Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
PubMed:	A systematic review of single chinese herbs for Alzheimer's disease treatment.
PubMed:	Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
PubMed:	Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
PubMed:	Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids.
PubMed:	Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
PubMed:	Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
PubMed:	Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.
PubMed:	Drug development for Alzheimer's disease: where are we now and where are we headed?
PubMed:	Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
PubMed:	The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease.
PubMed:	Huperzine A for vascular dementia.
PubMed:	BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
PubMed:	Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.
PubMed:	Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
PubMed:	Role of huperzine a in the treatment of Alzheimer's disease.
PubMed:	Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis.
PubMed:	Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.
PubMed:	Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.
PubMed:	Review: insufficient evidence on Huperzine A for Alzheimer's.
PubMed:	Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization Fourier transform mass spectrometry.
PubMed:	Alternative medicine and Alzheimer disease.
PubMed:	The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
PubMed:	Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs.
PubMed:	Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.
PubMed:	[Effects of microbes on rooting and on several physiological and biochemical indexes of cuttings of Huperzia serrata].
PubMed:	[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
PubMed:	Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
PubMed:	Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.
PubMed:	Comparison of methods used for the determination of cholinesterase activity in whole blood.
PubMed:	In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease.
PubMed:	Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.
PubMed:	Flexibility versus "rigidity" of the functional architecture of AChE active center.
PubMed:	Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.
PubMed:	Huperzine A for Alzheimer's disease.
PubMed:	Enzyme inhibitor screening by electrospray mass spectrometry with immobilized enzyme on magnetic silica microspheres.
PubMed:	[Progress of study on treatment of Alzheimer's disease with active ingredients of Chinese herbal medicines].
PubMed:	Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
PubMed:	Pharmacokinetics of huperzine A following oral administration to human volunteers.
PubMed:	Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs.
PubMed:	[Effects of huperzine A on cognitive function of rats recovering from general anesthesia].
PubMed:	An update on huperzine A as a treatment for Alzheimer's disease.
PubMed:	Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method.
PubMed:	Huprines for Alzheimer's disease drug development.
PubMed:	Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
PubMed:	Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis.
PubMed:	Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
PubMed:	The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.
PubMed:	East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
PubMed:	Complete (1)H NMR spectral fingerprint of huperzine A.
PubMed:	Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.
PubMed:	Huperzine A from Huperzia species--an ethnopharmacolgical review.
PubMed:	Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.
PubMed:	Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate.
PubMed:	Matrix-assisted laser desorption/ionization mass spectrometry (MALDI TOF MS) study of Huperzine A, a natural anti-Alzheimer's disease product, its derivatization and its detection by highly sensitive laser induced fluorescence (LIF).
PubMed:	Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.
PubMed:	Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice.
PubMed:	Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.
PubMed:	Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.
PubMed:	The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
PubMed:	Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
PubMed:	Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
PubMed:	[Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration].
PubMed:	Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.
PubMed:	Huperzine A in rat plasma and CSF following intranasal administration.
PubMed:	Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats.
PubMed:	A concise and convergent (formal) total synthesis of huperzine A.
PubMed:	Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
PubMed:	Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation.
PubMed:	Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
PubMed:	Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography.
PubMed:	[Plant metabolites as nootropics and cognitives].
PubMed:	[Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia].
PubMed:	Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines.
PubMed:	Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
PubMed:	Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.
PubMed:	Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease.
PubMed:	The determination of huperzine A in European Lycopodiaceae species by HPLC-UV-MS.
PubMed:	[Effect of preparation technique on in vitro release mechanism of huperzine A microspheres].
PubMed:	Editorial: natural products chemistry in China.
PubMed:	Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies.
PubMed:	Harmless herbs? Think again: merits of a complete medication history.
PubMed:	Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
PubMed:	[Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim].
PubMed:	Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation.
PubMed:	Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
PubMed:	Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs.
PubMed:	Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
PubMed:	[Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
PubMed:	Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
PubMed:	Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
PubMed:	Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations.
PubMed:	Acetylcholinesterase triggers the aggregation of PrP 106-126.
PubMed:	Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
PubMed:	Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.
PubMed:	[Synthesis and AchE inhibitory activity of 2-phenoxy-indan-1-one derivatives].
PubMed:	Herbal medicine in the treatment of Alzheimer's disease.
PubMed:	Butyrylcholinesterase in guinea pig lung lavage: a novel biomarker to assess lung injury following inhalation exposure to nerve agent VX.
PubMed:	Application of L-Amino acid in determination of Huperzine A by high performance liquid chromatography.
PubMed:	[Effect of yizhi jiannao granule on the behavior and neuron apoptosis in SAMP/8 mice].
PubMed:	High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts.
PubMed:	Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.
PubMed:	Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
PubMed:	Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases.
PubMed:	In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid).
PubMed:	Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation.
PubMed:	Pharmacological strategies for the prevention of Alzheimer's disease.
PubMed:	Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
PubMed:	A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales.
PubMed:	Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS.
PubMed:	Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection.
PubMed:	Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.
PubMed:	Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
PubMed:	Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.
PubMed:	Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
PubMed:	How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations.
PubMed:	Preparation and in vivo evaluation of huperzine A-loaded PLGA microspheres.
PubMed:	A survey of potential huperzine A natural resources in China: the Huperziaceae.
PubMed:	Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease.
PubMed:	Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks.
PubMed:	Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
PubMed:	Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
PubMed:	Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.
PubMed:	Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease.
PubMed:	[Advances on study of organophosphate poisoning prevented by Huperzine A].
PubMed:	Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
PubMed:	Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.
PubMed:	Huperzine A--human serum albumin association: chromatographic and thermodynamic approach.
PubMed:	Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China.
PubMed:	Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.
PubMed:	(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
PubMed:	Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.
PubMed:	Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.
PubMed:	The Lycopodium alkaloids.
PubMed:	Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.
PubMed:	Protective effect of tetramethylpyrazine on learning and memory function in D-galactose-lesioned mice.
PubMed:	Recent pharmacological studies on natural products in China.
PubMed:	Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons.
PubMed:	Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons.
PubMed:	Identification and characterization of the major huperzine a metabolite in rat blood.
PubMed:	Selagoline, a new alkaloid from Huperzia selago.
PubMed:	Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
PubMed:	Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells.
PubMed:	Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma.
PubMed:	A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry.
PubMed:	1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.
PubMed:	[Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats].
PubMed:	Huperzine A.
PubMed:	Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain.
PubMed:	Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A.
PubMed:	[Effect of tetramethylpyrazine on learning, memory and cholinergic system in D-galactose-lesioned mice].
PubMed:	Complementary and alternative medicines in the treatment of dementia: an evidence-based review.
PubMed:	Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease.
PubMed:	A convergent approach to huperzine A and analogues.
PubMed:	[Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].
PubMed:	Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.
PubMed:	Effects of huperzine A on liver cytochrome P-450 in rats.
PubMed:	Analysis of optically active compounds using conventional chromatography with a circular dichroism detector.
PubMed:	The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease.
PubMed:	Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle.
PubMed:	Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection.
PubMed:	Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases.
PubMed:	Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids.
PubMed:	Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.
PubMed:	Acute effects of huperzine A and tacrine on rat liver.
PubMed:	Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.
PubMed:	[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
PubMed:	Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
PubMed:	Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
PubMed:	Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
PubMed:	Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.
PubMed:	Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
PubMed:	Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia.
PubMed:	Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons.
PubMed:	X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
PubMed:	[Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial].
PubMed:	Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
PubMed:	Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons.
PubMed:	Review of the value of huperzine as pretreatment of organophosphate poisoning.
PubMed:	Have you had your moss today?
PubMed:	Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.
PubMed:	[Ethological examination of Alzheimer's disease model rats treated with bushen yizhi decoction].
PubMed:	The NMDA receptor ion channel: a site for binding of Huperzine A.
PubMed:	3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
PubMed:	Effects of chronic administration of huperzine A on memory in guinea pigs.
PubMed:	Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
PubMed:	Tricyclic cyanoguanidines: synthesis, site of action and insecticidal activity of a novel class of reversible acetylcholinesterase inhibitors.
PubMed:	Insecticidal activity of huperzine A from the New Zealand clubmoss, Lycopodium varium.
PubMed:	[Effects of bushen yizhi recipe on somatostatin-like immunopositive and somatostatin messenger ribonucleic acid expressed-positive neurons in Alzheimer's disease model rats].
PubMed:	Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice.
PubMed:	Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.
PubMed:	Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation.
PubMed:	Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
PubMed:	Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick.
PubMed:	Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.
PubMed:	Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells.
PubMed:	Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
PubMed:	Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.
PubMed:	Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation.
PubMed:	Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
PubMed:	Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
PubMed:	The pharmacology of novel acetylcholinesterase inhibitors, (+/-)-huprines Y and X, on the Torpedo electric organ.
PubMed:	Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
PubMed:	Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability.
PubMed:	Effects of Huperzine used as pre-treatment against soman-induced seizures.
PubMed:	Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.
PubMed:	Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance.
PubMed:	Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats.
PubMed:	Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors.
PubMed:	Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss.
PubMed:	New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
PubMed:	Similar potency of the enantiomers of huperzine A in inhibition of [(3)H]dizocilpine (MK-801) binding in rat cerebral cortex.
PubMed:	Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
PubMed:	Dementia research in China.
PubMed:	Synthesis of 5-substituted analogues of huperzine A.
PubMed:	Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury.
PubMed:	Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1.
PubMed:	Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.
PubMed:	Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells.
PubMed:	Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students.
PubMed:	Huperzine-A in capsules and tablets for treating patients with Alzheimer disease.
PubMed:	Huperzine A.
PubMed:	Treatment of Alzheimer's disease.
PubMed:	[Pretreatment of organophosphate poisoning: potential interests of huperzine A].
PubMed:	Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
PubMed:	Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease.
PubMed:	Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease.
PubMed:	Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
PubMed:	Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.
PubMed:	Predicting relative binding free energies of tacrine-huperzine A hybrids as inhibitors of acetylcholinesterase.
PubMed:	Suppressive action produced by beta-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-D-aspartate receptor-independent: it's offset by (-)huperzine A.
PubMed:	Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury.
PubMed:	[Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential].
PubMed:	Comparison of the effects of cholinesterase inhibitors on [3H]MK-801 binding in rat cerebral cortex.
PubMed:	Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
PubMed:	Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
PubMed:	Modulation of NMDA receptor by huperzine A in rat cerebral cortex.
PubMed:	Molecular dynamics of mouse acetylcholinesterase complexed with huperzine A.
PubMed:	Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
PubMed:	Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance.
PubMed:	Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
PubMed:	Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit.
PubMed:	Mouse acetylcholinesterase unliganded and in complex with huperzine A: a comparison of molecular dynamics simulations.
PubMed:	An analysis of low level doses of cholinesterase inhibitors in cultured neurons and hippocampal slices of rats.
PubMed:	Huperzine A--an interesting anticholinesterase compound from the Chinese herbal medicine.
PubMed:	Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.
PubMed:	Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.
PubMed:	Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.
PubMed:	Interpreting the effect of methyl group at the three carbon bridge of (-)-huperzine A on its anticholinesterase activity by molecular dynamics method.
PubMed:	Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity.
PubMed:	The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
PubMed:	Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
PubMed:	Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease.
PubMed:	Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
PubMed:	Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
PubMed:	Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
PubMed:	Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
PubMed:	Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy.
PubMed:	Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.
PubMed:	Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
PubMed:	Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality.
PubMed:	Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
PubMed:	Huperzine A, a novel promising acetylcholinesterase inhibitor.
PubMed:	Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.
PubMed:	Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.
PubMed:	Huperzine A ameliorates the spatial working memory impairments induced by AF64A.
PubMed:	Pharmacokinetics of tablet huperzine A in six volunteers.
PubMed:	Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.
PubMed:	Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.
PubMed:	Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines.
PubMed:	Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.
PubMed:	Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment.
PubMed:	[Intelligence promoting Chinese materia medica].
PubMed:	Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo.
PubMed:	Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program.
PubMed:	Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies.
PubMed:	Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.
PubMed:	Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
PubMed:	[Facilitation of cholinergic transmission by huperzine A in toad paravertebral ganglia in vitro].
PubMed:	Effect of cholinesterase inhibition in vitro by huperzine analogs.
PubMed:	Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
PubMed:	Revised Stereochemistry of So-Called Isoselagine and Spectroscopic Analysis of 6alpha-Hydroxylycopodine from Lycopodium serratum var. longipetiolatum.
PubMed:	Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo.
PubMed:	Mechanism of inhibition of cholinesterases by huperzine A.
PubMed:	Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
PubMed:	Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase.
PubMed:	Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters.
PubMed:	[Drug evaluation of huperzine A in the treatment of senile memory disorders].
PubMed:	Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease.
PubMed:	Development of natural products as drugs acting on central nervous system.
PubMed:	[Effects of huperzine A on electroencephalography power spectrum in rabbits].
PubMed:	Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
PubMed:	[Improvement of impaired memory in mice by huperzine A and huperzine B].
PubMed:	[Effects of huperzine A on cholinesterase isoenzymes in plasma of mice and dogs].
PubMed:	[Pharmacokinetics of huperzine A in rats and mice].
PubMed:	[Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment].
PubMed:	[Facilitatory effects of huperzine A and B on learning amd memory of spatial discrimination in mice].
PubMed:	[Effects of huperzine A and B on skeletal muscle and the electroencephalogram].
PubMed:	[Effects of huperzine A on learning and the retrieval process of discrimination performance in rats].
PubMed:	[Anti-cholinesterase activity of huperzine A].