vitex agnus-castus fruit
monks pepper berry
 
Notes:
a genus of trees in the verbenaceae (sometimes classified in the lamiaceae) family containing assorted flavonoids with possible analgesic and antineoplastic properties. the fruit of these trees is used in herbal preparations.
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Name: vitex agnus-castus fruit
CAS Number: 91722-47-3 
ECHA EC Number: 294-446-5
Category: food additive
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Bristol Botanicals
Agnus Castus seed powder Vitex agnus castus
Bristol Botanicals
Agnus Castus seed Vitex agnus castus
Bristol Botanicals
Agnus castus seed Vitex agnus castus
Pride International
Chaste Tree Berry
Whole Herb
Chaste Tree Berries
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: food additive
Recommendation for vitex agnus-castus fruit usage levels up to:
 not for fragrance use.
 
Recommendation for vitex agnus-castus fruit flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 vitex agnus-castus fruit
Chemidplus: 0091722473
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References:
 vitex agnus-castus fruit
Canada Domestic Sub. List: 91722-47-3
Pubchem (sid): 135346033
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Other Information:
FDA Listing of Food Additive Status: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 chasteberry fruit
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Synonyms:
 abraham's balm berry
 abrahams balm berry
 chaste tree berry
 chaste-tree berry
 chasteberry berry
 monk's pepper berry
 monks pepper berry
 vitex agnus castus fruit
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Articles:
PubMed: Metabolic profiling of Vitex agnus castus leaves, fruits and sprouts: analysis by LC/ESI/(QqQ)MS and (HR) LC/ESI/(Orbitrap)/MS n.
PubMed: Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract.
PubMed: Quality evaluation of medicinal products and health foods containing chaste berry (Vitex agnus-castus) in Japanese, European and American markets.
PubMed: Effects of "vitex agnus castus" extract and magnesium supplementation, alone and in combination, on osteogenic and angiogenic factors and fracture healing in women with long bone fracture.
PubMed: Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines.
PubMed: Liquid chromatography tandem mass spectrometry determination of chemical markers and principal component analysis of Vitex agnus-castus L. fruits (Verbenaceae) and derived food supplements.
PubMed: A new diterpenoid glucoside and two new diterpenoids from the fruit of Vitex agnus-castus.
PubMed: Differential attraction of Aedes albopictus in the field to flowers, fruits and honeydew.
PubMed: Phytoconstituents from Vitex agnus-castus fruits.
PubMed: Extraction, separation and isolation of volatiles from Vitex agnus-castus L. (Verbenaceae) wild species of Sardinia, Italy, by supercritical CO2.
PubMed: Three new diterpenoids from the fruit of Vitex agnus-castus.
PubMed: Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints.
PubMed: [The premenstrual syndrome: effectiveness of Vitex agnus castus].
PubMed: Vitex agnus-castus. Monograph.
PubMed: Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: a potential natural anti-cancer substance.
PubMed: Five new diterpenoids, viteagnusins A--E, from the fruit of Vitex agnus-castus.
PubMed: In vitro screening for the tumoricidal properties of international medicinal herbs.
PubMed: Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence?
PubMed: The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats.
PubMed: Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruits growing in Egypt.
PubMed: The effects of phytoestrogens on fracture healing: experimental research in New Zealand white rabbits.
PubMed: Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation.
PubMed: Reduced reproductive function in wild baboons (Papio hamadryas anubis) related to natural consumption of the African black plum (Vitex doniana).
PubMed: Antioxidant activity of Vitex agnus-castus L. extracts.
PubMed: Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents.
PubMed: Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS.
PubMed: A Vitex agnus-castus extract inhibits cell growth and induces apoptosis in prostate epithelial cell lines.
PubMed: Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress.
PubMed: Vitex agnus castus: a systematic review of adverse events.
PubMed: Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry).
PubMed: Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154].
PubMed: Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications.
PubMed: Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth.
PubMed: Vitexagnus-castus essential oil and menopausal balance: a self-care survey.
PubMed: Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study.
PubMed: Pharmacological activities of Vitex agnus-castus extracts in vitro.
PubMed: Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus.
PubMed: Composition of the essential fruit oil of Vitex agnus-castus.
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