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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 421.7 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for byakangelicin usage levels up to: | | | not for fragrance use.
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| Recommendation for byakangelicin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxyfuro[3,2-g]chromen-7-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10211 |
| Pubchem (cas): | 482-25-7 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | byak-angelicin | | (R)-9-(2,3- | dihydroxy-3-methylbutoxy)-4-methoxy-7H-furo(3,2-g)(1)benzopyran-7-one | | 9-[(2R)-2,3- | dihydroxy-3-methylbutoxy]-4-methoxyfuro[3,2-g]chromen-7-one | | 7H- | furo(3,2-g)(1)benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-, (R)- |
Articles:
| PubMed: | Spectrum Effect Relationship and Component Knock-Out in Angelica Dahurica Radix by High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer. |
| PubMed: | Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation. |
| PubMed: | Simultaneous determination and pharmacokinetics of sixteen Angelicae dahurica coumarins in vivo by LC-ESI-MS/MS following oral delivery in rats. |
| PubMed: | [Chemical constituents from polarity part in roots of Angelica dahurica var. formosana cv. Chuanbaizhi]. |
| PubMed: | [Chemical constituents from lipophilic parts in roots of Angelica dahurica var. formosana cv. Chuanbaizhi]. |
| PubMed: | [Quantitative determination of three active ingredients for quality evaluation of Angelica dahurica]. |
| PubMed: | Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio. |
| PubMed: | [Chemical constituents of Angelica nitida roots]. |
| PubMed: | Simultaneous determination of 13 chemical marker compounds in Gwakhyangjeonggi-san, a herbal formula, with validated analytical methods. |
| PubMed: | Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery. |
| PubMed: | Identification of the absorbed constituents after oral administration of Yuanhu Zhitong prescription extract and its pharmacokinetic study by rapid resolution liquid chromatography/quadrupole time-of-flight. |
| PubMed: | Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation. |
| PubMed: | [Study on the coumarin glucosides of Angelica dahurica]. |
| PubMed: | [A new natural product from root of Angelica dahurica cv. Qibaizhi]. |
| PubMed: | Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells. |
| PubMed: | [Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method]. |
| PubMed: | Sodium desoxycholate-assisted capillary electrochromatography with methacrylate ester-based monolithic column on fast separation and determination of coumarin analogs in Angelica dahurica extract. |
| PubMed: | Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry. |
| PubMed: | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. |
| PubMed: | An efficient strategy based on MAE, HPLC-DAD-ESI-MS/MS and 2D-prep-HPLC-DAD for the rapid extraction, separation, identification and purification of five active coumarin components from Radix Angelicae Dahuricae. |
| PubMed: | beta-secretase inhibitory effects of furanocoumarins from the root of Angelica dahurica. |
| PubMed: | Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS. |
| PubMed: | [Studies on chemical constituents of the roots of Angelica pubescens]. |
| PubMed: | [Studies on chemical constituents from fruits of Paliurus ramosissimus]. |
| PubMed: | Separation and quantitative analysis of coumarin compounds from Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook. f by pressurized capillary electrochromatography. |
| PubMed: | Agents protecting against sepsis from the roots of Angelica dahurica. |
| PubMed: | [Studies on quality standards of radix Angelicae dahuricae]. |
| PubMed: | Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae. |
| PubMed: | Identification of new urinary metabolites of byakangelicin, a component of Angelicae dahuricae Radix, in rats. |
| PubMed: | Constituents of Peucedanum zenkeri seeds and their antimicrobial effects. |
| PubMed: | Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production. |
| PubMed: | [Studies on chemical constituents of Peucedanum medium Dunn var. garcile Dunn ex Shan at Sheh]. |
| PubMed: | Crystal structure of byakangelicin (C17H18O7). |
| PubMed: | Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells. |
| PubMed: | Minor furocoumarins of Murraya koenigii. |
| PubMed: | Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica. |
| PubMed: | Effect of byakangelicin, an aldose reductase inhibitor, on galactosemic cataracts, the polyol contents and Na(+), K(+)ATPase activity in sciatic nerves of strepto-zotocin-induced diabetic rats. |
| PubMed: | Histamine-release effectors from Angelica dahurica var. dahurica root. |
| PubMed: | Studies on the antitumor-promoting activity of naturally occurring substances. II. Inhibition of tumor-promoter-enhanced phospholipid metabolism by umbelliferous materials. |
| PubMed: | Endocrinological studies on plant products. 8. Inhibitory effect of byakangelicin on and presence of sulphydryl group in pregnant mare's serum gonadotropin. |
| PubMed: | Endocrinological studies on plant products: VII. Further evidences on the presence of sulphydryl group in human chorionic gonadotropin and mechanism of action of byakangelicin. |
| PubMed: | Effect of byakangelicin on placental gonadotropins. |
| PubMed: | Endocrinological studies on plant products: V. Effect of byakangelicin on female sex hormones & on fertility of rats. |
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