|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 547.00 to 548.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 465.00 °F. TCC ( 240.60 °C. ) (est)
|
| logP (o/w): | 2.634 (est) |
| Soluble in: |
| | water, 24.04 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Sinensetin 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Sinensetin >98%
Odor: characteristic Use: Sinensetin is a natural flavonoid compound isolated from the fruit of Citrus aurantium L. Sinensetin exhibits the anti-inflammatory, antimutagenic and anticancer activities.
antimutagenic, anticancer, anti-inflammatory |
| Coompo |
| For experimental / research use only. |
| Sinensetin from Plants ≥98%
Odor: characteristic Use: Sinensetin exhibits anti-fungal, anti-histamine activity; induce cell differentiation, inhibition of linoleic acid oxidation, inhibition of white blood cells in the human zona protein Interleukin -1-induced expression of tissue factor. |
| ExtraSynthese |
| For experimental / research use only. |
| Sinensetin (HPLC) ≥99%
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Sinensetin
|
| Sigma-Aldrich |
| For experimental / research use only. |
| Sinensetin
analytical standard |
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for sinensetin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for sinensetin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 145659 |
| Pubchem (sid): | 135104143 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy- | | 2-(3,4- | dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one | | 2-(3,4- | dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one | | 5,6,7,3',4'- | pentamethoxyflavone |
Articles:
| PubMed: | Chemical fingerprint and metabolic profile analysis of Citrus reticulate 'Chachi' decoction by HPLC-PDA-IT-MS(n) and HPLC-Quadrupole-Orbitrap-MS method. |
| J-Stage: | Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of I?B-a |
| PubMed: | Orthosiphol A from the aerial parts of Orthosiphon aristatus is putatively responsible for hypoglycemic effect via alpha-glucosidase inhibition. |
| PubMed: | Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids. |
| PubMed: | Sonochemical effects on 14 flavonoids common in citrus: relation to stability. |
| PubMed: | 6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells. |
| PubMed: | Identification of sinensetin metabolites in rat urine by an isotope-labeling method and ultrahigh-performance liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed: | Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. |
| PubMed: | Chemical markers of shiikuwasha juice adulterated with calamondin juice. |
| PubMed: | Potent α-glucosidase and α-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanism. |
| PubMed: | A simple isocratic HPLC method for the simultaneous determination of sinensetin, eupatorin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in Orthosiphon stamineus extracts. |
| PubMed: | In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. |
| PubMed: | Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. |
| PubMed: | Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. |
| PubMed: | Effects of sinensetin on lipid metabolism in mature 3T3-L1 adipocytes. |
| PubMed: | [Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells]. |
| PubMed: | Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. |
| PubMed: | In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes. |
| PubMed: | Evaluation of the genotoxicity of Orthosiphon stamineus aqueous extract. |
| PubMed: | HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves. |
| PubMed: | Isolation of adenosine, iso-sinensetin and dimethylguanosine with antioxidant and HIV-1 protease inhibiting activities from fruiting bodies of Cordyceps militaris. |
| PubMed: | Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. |
| PubMed: | Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. |
| PubMed: | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. |
| PubMed: | Suppression of bacterial cell-cell signalling, biofilm formation and type III secretion system by citrus flavonoids. |
| PubMed: | CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells. |
| PubMed: | UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii. |
| PubMed: | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| PubMed: | Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts. |
| PubMed: | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. |
| PubMed: | Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. |
| PubMed: | Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells. |
| PubMed: | Characterization of polymethoxylated flavones in Fructus aurantii by liquid chromatography with atmospheric pressure chemical ionization combined with tandem mass spectrometry. |
| PubMed: | Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography. |
| PubMed: | Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China. |
| PubMed: | Liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance as complementary analytical techniques for unambiguous identification of polymethoxylated flavones in residues from molecular distillation of orange peel oils (Citrus sinensis). |
| PubMed: | Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. |
| PubMed: | Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection. |
| PubMed: | Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora. |
| PubMed: | Effect of extraction method on the concentrations of selected bioactive compounds in mandarin juice. |
| PubMed: | Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3',4'-pentamethoxyflavone (Sinensetin). |
| PubMed: | Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels. |
| PubMed: | Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. |
| PubMed: | Immunotoxicity of a standardized citrus polymethoxylated flavone extract. |
| PubMed: | Inhibitors of 15-lipoxygenase from orange peel. |
| PubMed: | Constituents of the Vietnamese medicinal plant Orthosiphon stamineus. |
| PubMed: | Inhibition of metallopeptidases by flavonoids and related compounds. |
| PubMed: | A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. |
| PubMed: | Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium. |
| PubMed: | Simultaneous separation of flavanone glycosides and polymethoxylated flavones in citrus juices using liquid chromatography. |
| PubMed: | Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. |
| PubMed: | C18 solid-phase isolation and high-performance liquid chromatography/ultraviolet diode array determination of fully methoxylated flavones in citrus juices. |
| PubMed: | Flavones in citrus exhibit antiadhesive action on platelets. |
| PubMed: | Flavonoids from Chenopodium botrys. |
| PubMed: | Quantitation of polymethoxylated flavones in orange juice by high-performance liquid chromatography. |
|