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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 262.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 430.38 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 364.00 °F. TCC ( 184.50 °C. ) (est)
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| logP (o/w): | 0.884 (est) |
| Soluble in: |
| | alcohol | | | water, 7.213e+004 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 429 mg/kg Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 87, 1987.
intravenous-mouse LD50 375 mg/kg Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 87, 1987.
oral-mouse LD50 5370 mg/kg Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 87, 1987.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for daphnetin usage levels up to: | | | not for fragrance use.
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| Recommendation for daphnetin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2H-1- | benzopyran-2-one, 7,8-dihydroxy- | | 2H-1- | benzopyran-2-one, 7,8-dihydroxy- (9CI) | | | coumarin, 7,8-dihydroxy- | | | daphnetol | | 7,8- | dihydroxy-2H-1-benzopyran-2-one | | 7,8- | dihydroxy-2H-chromen-2-one | | 7,8- | dihydroxy-chromen-2-one | | 7,8- | dihydroxy-coumarin | | 7,8- | dihydroxychromen-2-one | | 7,8- | dihydroxycoumarin |
Articles:
| PubMed: | Immunosuppressive Activity of Daphnetin, One of Coumarin Derivatives, Is Mediated through Suppression of NF-κB and NFAT Signaling Pathways in Mouse T Cells. |
| PubMed: | Daphnetin attenuates microglial activation and proinflammatory factor production via multiple signaling pathways. |
| PubMed: | The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats. |
| PubMed: | Protective effects of daphnetin on sodium taurocholate‑induced severe acute pancreatitis in rats. |
| PubMed: | Total synthesis of six 3,4-unsubstituted coumarins. |
| PubMed: | Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury. |
| PubMed: | Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives. |
| PubMed: | 7,8-dihydroxycoumarin may promote sciatic nerve regeneration by suppressing NF-κB expression in mice. |
| PubMed: | 7,8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of Akt/NF-κB signaling. |
| PubMed: | Coumarins of Matricaria chamomilla L.: aglycones and glycosides. |
| PubMed: | 7,8-Dihydroxy coumarin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells. |
| PubMed: | Isolation and characterization of polyphenol oxidase from Sardinian poisonous and non-poisonous chemotypes of Ferula communis (L.). |
| PubMed: | Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris. |
| PubMed: | [Chemical constituents from rhizome of Daphne papyracea var. crassiuscula]. |
| PubMed: | Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons. |
| PubMed: | Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. |
| PubMed: | Daphnetin methylation stabilizes the activity of phosphoribulokinase in wheat during cold acclimation. |
| PubMed: | Biotransformation of hydroxycoumarin derivatives by cultured suspension cells of Catharanthus roseus. |
| PubMed: | Daphnetin prevents chronic unpredictable stress-induced cognitive deficits. |
| PubMed: | The therapeutic effects of daphnetin in collagen-induced arthritis involve its regulation of Th17 cells. |
| PubMed: | Efficacy of Daphne oleoides subsp. kurdica used for wound healing: identification of active compounds through bioassay guided isolation technique. |
| PubMed: | [Analysis of metabolites of daphnetin in the intestinal wall of rats by liquid chromatography and quatrupole-time of flight mass spectrometry]. |
| PubMed: | Regulatory effect of daphnetin, a coumarin extracted from Daphne odora, on the balance of Treg and Th17 in collagen-induced arthritis. |
| PubMed: | [Chemical constituents of Daphne odora var. margirmta]. |
| PubMed: | [Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats]. |
| PubMed: | Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. |
| PubMed: | [Biotransformation of daphnetin by suspension transgenic hairy roots of Polygonum multiflorum]. |
| PubMed: | Potential utility of daphnetin as a novel treatment for pemphigus vulgaris. |
| PubMed: | [Studies on the chemical constituents from Daphne tangutica]. |
| PubMed: | Novel insights into the mechanism of decreased expression of type X collagen in human mesenchymal stem cells from patients with osteoarthritis cultured on nitrogen-rich plasma polymers: implication of cyclooxygenase-1. |
| PubMed: | Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of daphnetin. |
| PubMed: | [Intestinal absorption of daphnetin by rats single pass perfusion in situ]. |
| PubMed: | Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships. |
| PubMed: | Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. |
| PubMed: | Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor. |
| PubMed: | Therapeutic effects of daphnetin on adjuvant-induced arthritic rats. |
| PubMed: | Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin. |
| PubMed: | In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum. |
| PubMed: | [In vitro effect of daphnetin on cytochrome C oxidase and ribonucleotide reductase of plasmodium falciparum]. |
| PubMed: | Determination of kava lactones and flavonoid glycoside in Scorzonera austriaca by capillary zone electrophoresis. |
| PubMed: | Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). |
| PubMed: | [Studies on the chemical constituents in roots of Daphne odora var. atrocaulis]. |
| PubMed: | Comparative study on schizontocidal activity of recrystallized or crude daphnetin against malaria parasites. |
| PubMed: | Solid-phase extraction of esculetin from the ash bark of Chinese traditional medicine by using molecularly imprinted polymers. |
| PubMed: | [Additive therapeutic effect of a combination of artemether and daphnetin against Plasmodium berghei in mice]. |
| PubMed: | Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities. |
| PubMed: | Iron chelator daphnetin against Pneumocystis carinii in vitro. |
| PubMed: | Binding of the bioactive component daphnetin to human serum albumin demonstrated using tryptophan fluorescence quenching. |
| PubMed: | Bioactivity guided isolation of antifungal compounds from the liverwort Bazzania trilobata (L.) S.F. Gray. |
| PubMed: | Spectrofluorimetric study of the binding of daphnetin to bovine serum albumin. |
| PubMed: | Daphnetin induced differentiation of human renal carcinoma cells and its mediation by p38 mitogen-activated protein kinase. |
| PubMed: | [Effect of daphnetin on SOD activity and DNA synthesis of Plasmodium falciparum in vitro]. |
| PubMed: | Identification and characterisation of the chinese herb Langdu by LC-MS/MS analysis. |
| PubMed: | [Effect of daphnetin on the exo-erythrocytic stage of rodent malaria]. |
| PubMed: | The schizontocidal activity of daphnetin against malaria parasites in vitro and in vivo. |
| PubMed: | In vitro antimalarial effect of daphnetin relating to its iron-chelating activity. |
| PubMed: | [Anti-hemolytic and anti-membranous lipid peroxidation effects of daphnetin]. |
| PubMed: | Daphnetin methylation by a novel O-methyltransferase is associated with cold acclimation and photosystem II excitation pressure in rye. |
| PubMed: | In vitro cytotoxic potential and mechanism of action of selected coumarins, using human renal cell lines. |
| PubMed: | Coumarin glucosides from Cruciata taurica. |
| PubMed: | Antimicrobial evaluation of coumarins and flavonoids from the stems of Daphne gnidium L. |
| PubMed: | In vitro inhibitory effects of Daphne oleoides ssp. oleoides on inflammatory cytokines and activity-guided isolation of active constituents. |
| PubMed: | [Sensitization and crossreaction of simple coumarins]. |
| PubMed: | Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. |
| PubMed: | [Scavenging effects of daphnetin and its Cu, Zn complexes on superoxide radical]. |
| PubMed: | [Chemical constituents of Stellera chamaejasme L]. |
| PubMed: | Studies on the preparation of bioactive lignans by oxidative coupling reaction. IV. Oxidative coupling reaction of methyl (E)-3-(3,4-dihydroxy-2-methoxyphenyl)propenoate and lipid peroxidation inhibitory effects of the produced lignans. |
| PubMed: | Antimalarial quinones: redox potential dependence of methemoglobin formation and heme release in erythrocytes. |
| PubMed: | [Preparation method and quality control of compound Daphne injection]. |
| PubMed: | Activated oxygen generation by a primaquine metabolite: inhibition by antioxidants derived from Chinese herbal remedies. |
| PubMed: | Daphnetin: a novel antimalarial agent with in vitro and in vivo activity. |
| PubMed: | [Effect of daphnetin on lipoprotein cholesterol content of serum]. |
| PubMed: | The sensitizing capacity of coumarins (II). |
| PubMed: | [Antithrombotic effect of daphnetin in the rat]. |
| PubMed: | Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins. |
| PubMed: | [The relationship between daphnetin analgesia and central neurotransmitters of monoamines]. |
| PubMed: | [Metabolism and pharmacokinetics of daphnetin]. |
| PubMed: | Characteristics of coumarin metabolism by liver microsomes from cobalt-pretreated mice. |
| PubMed: | Isolation of daphnetin-8-beta-glucoside from Daphne acuminata. |
| PubMed: | Isolation of daphnetin-8-beta-glucoside from Daphne papyracea. |
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