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Category: nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | -1.747 (est) |
| Soluble in: |
| | water, 1996 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 365 mg/kg Toxicology and Applied Pharmacology. Vol. 44, Pg. 225, 1978.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | nutrient supplements |
| Recommendation for riboflavin 5'-phosphate usage levels up to: | | | not for fragrance use.
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| Recommendation for riboflavin 5'-phosphate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Assessment of one published review on health risks associated with phosphate additives in food View page or View pdf |
Safety and efficacy of vitamin B2 (riboflavin and riboflavin 5’-phosphate ester monosodium salt) produced by Bacillus subtilis for all animal species based on a dossier submitted by DSM View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8965 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | [(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate |
| Chemidplus: | 0000146178 |
References:
| | [(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 8965 |
| Pubchem (sid): | 134974780 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| [(2S,3R,4R)-5-(7,8- | dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate | | | flanin | | | riboflavin mononucleotide | | | riboflavine dihydrogen phosphate | | | vitamin B2 phosphate |
Articles:
| PubMed: | A thixotropic supramolecular hydrogel of adenine and riboflavin-5'-phosphate sodium salt showing enhanced fluorescence properties. |
| PubMed: | Matrix tablets based on a carrageenan with the modified-release of sodium riboflavin 5'-phosphate. |
| PubMed: | Evaluating in vivo delivery of riboflavin with coulomb-controlled iontophoresis for corneal collagen cross-linking: a pilot study. |
| PubMed: | [Ion-pair HPLC analysis of B vitamins in syrup products in Indonesia]. |
| PubMed: | Modified-release capsules containing sodium riboflavin 5'-phosphate. |
| PubMed: | Tailored beads made of dissolved cellulose--investigation of their drug release properties. |
| PubMed: | Electron acceptor dependence of electron shuttle secretion and extracellular electron transfer by Shewanella oneidensis MR-1. |
| PubMed: | Enhancement of corneal permeation of riboflavin-5'-phosphate through vitamin E TPGS: a promising approach in corneal trans-epithelial cross linking treatment. |
| PubMed: | Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride. |
| PubMed: | The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase. |
| PubMed: | Simultaneous controlled vitamin release from multiparticulates: theory and experiment. |
| PubMed: | A novel riboflavin gastro-mucoadhesive delivery system based on ion-exchange fiber. |
| PubMed: | Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method. |
| PubMed: | Shewanella secretes flavins that mediate extracellular electron transfer. |
| PubMed: | Molecular determinants for FMN-binding in Desulfovibrio gigas flavoredoxin. |
| PubMed: | Relationship between the redox change in yellow fluorescent protein of Vibrio fischeri strain Y1 and the reversible change in color of bioluminescence in vitro. |
| PubMed: | Activity coupling of Vibrio harveyi luciferase and flavin reductase (FRP): oxygen as a probe. |
| PubMed: | Kinetic mechanism and quaternary structure of Aminobacter aminovorans NADH:flavin oxidoreductase: an unusual flavin reductase with bound flavin. |
| PubMed: | Energy transfer evidence for in vitro and in vivo complexes of Vibrio harveyi flavin reductase P and luciferase. |
| PubMed: | A two [4Fe-4S]-cluster-containing ferredoxin as an alternative electron donor for 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. |
| PubMed: | Automated determination of selected water-soluble vitamins in tablets using a bench-top robotic system coupled to reversed-phase (RP-18) HPLC with UV detection. |
| PubMed: | Rapid determination of thiamine, riboflavin, pyridoxine, and niacinamide in infant formulas by liquid chromatography. |
| PubMed: | The iron-sulfur clusters in 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. Biochemical and spectroscopic investigations. |
| PubMed: | Activities of the bimodal fluorescent protein produced by Photobacterium phosphoreum strain bmFP in the luciferase reaction in vitro. |
| PubMed: | 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum. |
| PubMed: | Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food. |
| PubMed: | Computational analysis of the oxygen addition at the C4a site of reduced flavin in the bacterial luciferase bioluminescence reaction. |
| PubMed: | Effects of mutations of the alpha His45 residue of Vibrio harveyi luciferase on the yield and reactivity of the flavin peroxide intermediate. |
| PubMed: | Preparation of riboflavin 4',5'-cyclic phosphate by incubation of flavin-adenine dinucleotide with Mn2+ in the absence of riboflavin 5'-phosphate cyclase. |
| PubMed: | Development of a novel controlled-release system for gastric retention. |
| PubMed: | Extent of Intramolecular Aromatic-Ring Stacking in Ternary Cu(2+) Complexes Formed by 2,2'-Bipyridyl or 1,10-Phenanthroline and Flavin Mononucleotide (FMN(2)(-))(1)(,)(2). |
| PubMed: | Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by vitamins, porphyrins and related compounds, and vegetable and fruit juices and solvent extracts. |
| PubMed: | Binding of the oxidized, reduced, and radical flavin species to chorismate synthase. An investigation by spectrophotometry, fluorimetry, and electron paramagnetic resonance and electron nuclear double resonance spectroscopy. |
| PubMed: | Kinetics and thermodynamics of the binding of riboflavin, riboflavin 5'-phosphate and riboflavin 3',5'-bisphosphate by apoflavodoxins. |
| PubMed: | Cloning and analysis of structural genes from Streptomyces pristinaespiralis encoding enzymes involved in the conversion of pristinamycin IIB to pristinamycin IIA (PIIA): PIIA synthase and NADH:riboflavin 5'-phosphate oxidoreductase. |
| PubMed: | Purification of the two-enzyme system catalyzing the oxidation of the D-proline residue of pristinamycin IIB during the last step of pristinamycin IIA biosynthesis. |
| PubMed: | Catalytically active forms of the individual subunits of Vibrio harveyi luciferase and their kinetic and binding properties. |
| PubMed: | Probing the Vibrio harveyi luciferase beta subunit functionality and the intersubunit domain by site-directed mutagenesis. |
| PubMed: | Mechanism of aldehyde inhibition of Vibrio harveyi luciferase. Identification of two aldehyde sites and relationship between aldehyde and flavin binding. |
| PubMed: | Purification and characterization of a NADH oxidase from the thermophile Thermus thermophilus HB8. |
| PubMed: | Flavin levels in the rat retina. |
| PubMed: | [Effect of preliminarily administered aspartate to the body and its combination with a vitamin-coenzyme complex on the catabolism of L-[14C]-aspartate in tissues of various mouse organs in hermetically closed space]. |
| PubMed: | Amplified colorimetric assay of alkaline phosphatase using riboflavin 4'-phosphate: a simple method for measuring riboflavin and riboflavin 5'-phosphate. |
| PubMed: | A new reducing agent of flavins and its application to the assay of bacterial luciferase. |
| PubMed: | Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase activity. |
| PubMed: | [Mechanisms of organic drug electrophoresis]. |
| PubMed: | Analysis of water-soluble vitamins in total parenteral nutrition solution by high pressure liquid chromatography. |
| PubMed: | Enhancement of adriamycin-induced mortality during riboflavin administration and riboflavin deficiency in rats. |
| PubMed: | The simultaneous assay of riboflavin 5-phosphate sodium and other water-soluble vitamins in liquid multivitamin formulations by liquid chromatograph. |
| PubMed: | Quantification of riboflavin, riboflavin 5'-phosphate and flavin adenine dinucleotide in plasma and urine by high-performance liquid chromatography. |
| PubMed: | Riboflavin metabolism in the hypothyroid human adult. |
| PubMed: | A comparative carbon-13, nitrogen-15, and phosphorus-31 nuclear magnetic resonance study on the flavodoxins from Clostridium MP, Megasphaera elsdenii, and Azotobacter vinelandii. |
| PubMed: | Vitamin stability in a TPN mixture stored in an EVA plastic bag. |
| PubMed: | [A variant of pathogenetic therapy in the acute period of perinatal hypoxic-traumatic brain lesions in premature infants]. |
| PubMed: | Carbon-13 and nitrogen-15 nuclear-magnetic-resonance investigation on Desulfovibrio vulgaris flavodoxin. |
| PubMed: | Effects of vitamins on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells. |
| PubMed: | Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro. |
| PubMed: | Metabolism of vitamin B-6 by human liver. |
| PubMed: | Direct cross-linking of three domains in the myosin head. |
| PubMed: | In-vitro riboflavin binding and endogenous flavins in Phycomyces blakesleeanus. |
| PubMed: | On the mobility of riboflavin 5'-phosphate in Megasphaera elsdenii flavodoxin as studied by 13C-nuclear-magnetic-resonance relaxation. |
| PubMed: | Phosphates of riboflavin and riboflavin analogs: a reinvestigation by high-performance liquid chromatography. |
| PubMed: | Isolation of bacterial luciferases by affinity chromatography on 2,2-diphenylpropylamine-Sepharose: phosphate-mediated binding to an immobilized substrate analogue. |
| PubMed: | Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate. |
| PubMed: | Studies on the NADH and NADPH: riboflavin 5'-phosphate (FMN) oxidoreductases from Beneckea harveyi: characterization of the FMN binding sites. |
| PubMed: | New polyacrylamide matrices for drift-free isoelectric focusing. |
| PubMed: | Structural and dynamic information on the complex of Megasphaera elsdenii apoflavodoxin and riboflavin 5'-phosphate. A phosphorus-31 nuclear magnetic resonance study. |
| PubMed: | Binding of 2,2-diphenylpropylamine at the aldehyde site of bacterial luciferase increases the affinity of the reduced riboflavin 5'-phosphate site. |
| PubMed: | Interaction of riboflavin-5'-phosphate with poly-(alpha-L-lysine) & poly-(alpha-L-histidine) in aqueous medium. |
| PubMed: | Apoflavodoxin aggregation following dissociation of flavin. |
| PubMed: | Preparation and properties of immobilized flavokinase. |
| PubMed: | Spectroscopic studies of pyridoxamine (pyridoxine) 5'-phosphate oxidase. Equilibrium dissociation constants and spectra for riboflavin 5'-phosphate and analogues. |
| PubMed: | Solubilization and properties of a particulate hydrogenase from Methanobacterium strain G2R. |
| PubMed: | Purification and properties of nitroalkane oxidase from Fusarium oxysporum. |
| PubMed: | In vitro photodecomposition of uric acid in presence of riboflavin II. |
| PubMed: | A route dependent bioavailability in active metabolite suggested in riboflavin-5'-phosphate pharmacokinetics. |
| PubMed: | A continuous fluorometric assay for flavokinase. Properties of flavokinase from Peptostreptococcus elsdenii. |
| PubMed: | 15N nuclear magnetic resonance of flavins. |
| PubMed: | Histochemistry of normal and diseased human lymph nodes. |
| PubMed: | Properties of immobilized flavodoxin from Peptostreptococcus elsdenii. An affinity ligand for the purification of riboflavin 5'-phosphate (FMN) and its analogues. |
| PubMed: | Fluorescence titration with apoflavodoxin: a sensitive assay for riboflavin 5'-phosphate and flavin adenine dinucleotide in mixtures. |
| PubMed: | Effect of carbonated beverages and of an antiemetic containing carbohydrate and phosphoric acid on riboflavin bioavailability and salicylamide biotransformation in humans. |
| PubMed: | [Effect of riboflavin mononucleotide, ATP and nospanum hydrochloricum on the electric activity of the retina, ocular hemodynamics and ophthalmotonus (experimental-clinical study)]. |
| PubMed: | [Characteristics of the subconjunctival administration of a riboflavin-mononucleotide solution]. |
| PubMed: | The binding of riboflavin-5'-phosphate in a flavoprotein: flavodoxin at 2.0-Angstrom resolution. |
| PubMed: | [Riboflavin-mononucleotide in the ophthalmic practice]. |
| PubMed: | [Riboflavin mononucleotide]. |
| PubMed: | Riboflavin 5'-phosphate: a potent activator or brain glutaminase. |
| PubMed: | Studies on riboflavin metabolism in the rat. 3. Disappearance rate and urinary excretion rate of flavin after intravenous infusion of riboflavin-5'-phosphate. |
| PubMed: | Studies on riboflavin metabolism in the rat. I. Urinary and faecal excretion after oral administration of riboflavin-5'-phosphate. |
| PubMed: | Plasma protein binding of riboflavin and riboflavin-5'-phosphate in man. |
| PubMed: | Studies on riboflavin metabolism in the rat. II. Metabolic flavin elimination after oral or intraperitoneal administration of riboflavin-5'-phosphate. |
| PubMed: | Absorption, metabolism, and excretion of riboflavin-5'-phosphate in man. |
| PubMed: | Hydrolysis of riboflavin 5'-phosphate by phosphatases of rat kidney. |
| PubMed: | [Resorption of cocarboxylase, riboflavin-5'-phosphate sodium and vitamin A in the colon]. |
| PubMed: | [Riboflavin-5'-phosphate as electron donor in photosensibilized reduction of oxidized glutathione]. |
| PubMed: | [Riboflavin-5'-phosphate and hematoporphyrin sensitized by photooxidation of yeast alcohol dehydrogenase]. |
| PubMed: | Interaction between riboflavin and rutin. |
| PubMed: | Metal chelates and antitubercular activity. V. Riboflavin, riboflavin-5'-phosphate, alloxan, phthaloylhydrazine. |
| PubMed: | Photooxidations catalyzed by plant and bacterial extracts and by riboflavin-5'-phosphate. |
| PubMed: | [Influence of the reaction of the medium on the chemical hydrolysis of riboflavin-5'-phosphate]. |
| PubMed: | Synthetic riboflavin-5'-phosphate. |
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