bile extract
 
Notes:
tsca definition 2008: extractives and their physically modified derivatives such as proteins, lipids, carbohydrates, nucleic acids, inorganic ions, etc. obtained from mammalian bile.
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CAS Number: 8008-63-7 
MDL: MFCD00130641
Category: emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
184.1560 Ox bile extract View - review
FDA Mainterm (SATF):8008-63-7 ; OX BILE EXTRACT
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1560 Ox bile extract.
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
American Laboratories
Extract of Hog Bile Granular 038
American Laboratories
Extract of Hog Bile Powder 037
American Laboratories
Extract of Ox Bile Fine Granular 730
American Laboratories
Extract of Ox Bile Granular 034
American Laboratories
Extract of Ox Bile Powder 033
American Laboratories
Extract of Ox Bile Powder, 45% Cholic Acid 145
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for bile extract usage levels up to:
 not for fragrance use.
 
Recommendation for bile extract flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on monitoring procedures at slaughterhouses for pigs
View page or View pdf
EPA Substance Registry Services (TSCA): 8008-63-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0008008637
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References:
Canada Domestic Sub. List: 8008-63-7
Pubchem (sid): 135361689
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
FDA Listing of Food Additive Status: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
hog bile extract
ox bile extract
 oxgall extract powdered
 sodium choleate
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Articles:
PubMed: Bile-mediated activation of the acrAB and tolC multidrug efflux genes occurs mainly through transcriptional derepression of ramA in Salmonella enterica serovar Typhimurium.
PubMed: Validation of candidate reference genes in Bifidobacterium adolescentis for gene expression normalization.
PubMed: Anti-inflammatory activity of bioaccessible fraction from Eryngium foetidum leaves.
PubMed: Isolation and characterization of antifungal compound from Lactobacillus plantarum KCC-10 from forage silage with potential beneficial properties.
PubMed: Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride.
PubMed: Apoptosis induced by aqueous extracts of crocodile bile in human heptacarcinoma SMMC-7721.
PubMed: Development of a standardised human in vitro digestion protocol based on macronutrient digestion using response surface methodology.
PubMed: Effect of prebiotic carbohydrates on the growth and tolerance of Lactobacillus.
PubMed: Apoptosis mechanism of human cholangiocarcinoma cells induced by bile extract from crocodile.
PubMed: Transport across Caco-2 cell monolayer and sensitivity to hydrolysis of two anxiolytic peptides from αs1-casein, α-casozepine, and αs1-casein-f91-97: effect of bile salts.
PubMed: Anti-inflammatory activity of the oriental herb medicine, Arisaema cum Bile, in LPS-induced PMA-differentiated THP-1 cells.
PubMed: In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems.
PubMed: Bioaccessibility of carotenoids and vitamin e from pasta: evaluation of an in vitro digestion model.
PubMed: Probiotic potential of Staphylococcus hominis MBBL 2-9 as anti-Staphylococcus aureus agent isolated from the vaginal microbiota of a healthy woman.
PubMed: Mutagenicity of blue rayon extracts of fish bile as a biomarker in a field study.
PubMed: Identification of metabolites in human hepatic bile using 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS.
PubMed: Bioaccessibility of phenols in common beans ( Phaseolus vulgaris L.) and iron (Fe) availability to Caco-2 cells.
PubMed: Effect of interfacial protein cross-linking on the in vitro digestibility of emulsified corn oil by pancreatic lipase.
PubMed: Concentrations and bioaccessibility of polycyclic aromatic hydrocarbons in wastewater-irrigated soil using in vitro gastrointestinal test.
PubMed: Influence of lipid physical state on the in vitro digestibility of emulsified lipids.
PubMed: Calcium from LactoCalcium milk mineral after digestion with pepsin stimulates mineralized bone nodule formation in human osteoblast-like SaOS-2 cells in vitro and may be rendered bioavailable in vivo.
PubMed: Arsenic bioaccessibility and speciation in clams and seaweed from a contaminated marine environment.
PubMed: Probiotic properties of Lactobacillus and Bifidobacterium strains isolated from porcine gastrointestinal tract.
PubMed: [In vitro screening of 32 traditional Chinese herbal extracts against U2OS human osteosarcoma cells].
PubMed: Assessment of the bioaccessibility of polycyclic aromatic hydrocarbons in soils from Beijing using an in vitro test.
PubMed: Arsenosugars in raw and cooked edible seaweed: characterization and bioaccessibility.
PubMed: Proteomic analysis of global changes in protein expression during bile salt exposure of Bifidobacterium longum NCIMB 8809.
PubMed: In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media.
PubMed: Stability and bioaccessibility of isoflavones from soy bread during in vitro digestion.
PubMed: Assimilation of cholesterol by yeast strains isolated from infant feces and Feta cheese.
PubMed: Estimation of arsenic bioaccessibility in edible seaweed by an in vitro digestion method.
PubMed: Stability of recombinant human alpha-1-antitrypsin produced in rice in infant formula.
PubMed: Breast milk fractions solubilize Fe(III) and enhance iron flux across Caco-2 cells.
PubMed: In vitro excystation of Haplorchis taichui (Trematoda: Heterophyidae).
PubMed: Estimation of carotenoid accessibility from carrots determined by an in vitro digestion method.
PubMed: Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon.
PubMed: Estimation of carotenoid bioavailability from fresh stir-fried vegetables using an in vitro digestion/Caco-2 cell culture model.
PubMed: Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli.
PubMed: Development of an in vitro digestion method to assess carotenoid bioavailability from meals.
PubMed: Effects of the composition of bacteriological growth media on a chemiluminometric assay of beta-galactosidase in Escherichia coli.
PubMed: Malt-yeast extract-sucrose agar, a suitable medium for enumeration and isolation of fungi from silage.
PubMed: Caco-2 cell iron uptake from meat and casein digests parallels in vivo studies: use of a novel in vitro method for rapid estimation of iron bioavailability.
PubMed: Modification of an in-vitro method for estimating the bioavailability of zinc and calcium from foods.
PubMed: 32P-postlabeling of bile components: bulky adduct-like behavior in polyethyleneimine-cellulose thin layer chromatography.
PubMed: Luminal bile salts and neurotensin release in the isolated vascularly perfused rat jejuno-ileum.
PubMed: Physico-chemical conditions necessary for the in vitro excystment of Zygocotyle lunata (Trematoda:Paramphistomatidae).
PubMed: Treatment of severe steatorrhea with ox bile in an ileectomy patient with residual colon.
PubMed: Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide.
PubMed: Plasma electrolyte changes after ingestion of bile extract of the grass carp (Ctenopharyngodon idellus) in rats.
PubMed: Lipid analysis of Giardia lamblia and its culture medium.
PubMed: Bile acids from the harp seals, Phoca groenlandica.
PubMed: Use of 125I-labeled-histamine-cyclosporin C for monitoring serum cyclosporine concentrations in transplantation patients.
PubMed: Methadone metabolism in the rat in vivo: identification of a novel formamide metabolite.
PubMed: The renal, cardiovascular and hemolytic actions in the rat of a toxic extract from the bile of the grass carp (Ctenopharyngodon idellus).
PubMed: The comparison of six media for chlamydospore production by Candida albicans.
PubMed: Rapid identification of Bacteroides fragilis with bile and antibiotic disks.
PubMed: [Protection against histamine bronchospasm and Herxheimer anaphylactic microshock using a bile extract].
PubMed: Modified Littman oxgall agar to isolate Cryptococcus neoformans.
PubMed: [CLINICAL, PHYSIOPATHOLOGICAL AND PHARMACODYNAMIC DATA FOR THE TREATMENT OF ESSENTIAL ARTERIAL HYPERTENSION WITH A BILE EXTRACT OR DIALYSATE].
PubMed: [Qualitative determination of ox bile extract].
PubMed: Hog bile extract; an identification test.
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