monopotassium glutamate
L-glutamic acid potassium salt (1:1)
 
Notes:
salts and esters of glutamic acid. Flavour enhancer; salt substitute Monopotassium glutamate is a compound with formula KC5H8NO4. It is a potassium acid salt of glutamic acid.; See glutamic acid for more information. This compound is a non-sodium MSG alternative.
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CAS Number: 19473-49-5Picture of molecule3D/inchi
Other(deleted CASRN): 70938-17-9
ECHA EINECS - REACH Pre-Reg: 243-094-0
FDA UNII: GQ82EXX32T
Molecular Weight: 185.22086000
Formula: C5 H8 K N O4
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor enhancers, salt substitute
 
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 FDA/DG SANTE Petitions, Reviews, Notices:
182.1516 Monopotassium L-glutamate View - review
JECFA Food Additive: Monopotassium L-Glutamate
GSFA Codex: Monopotassium L-glutamate (622)
DG SANTE Food Additives: monopotassium glutamate
FDA Mainterm (SATF):19473-49-5 ; MONOPOTASSIUM GLUTAMATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart D--Special Dietary and Nutritional Additives
Sec. 172.320 Amino acids.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart B--Multiple Purpose GRAS Food Substances
Sec. 182.1516 Monopotassium glutamate.
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Physical Properties:
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Ajinomoto USA
Monopotassium Glutamate
Flavor: characteristic
Effective, low-sodium flavor enhancers which provide exceptional mouthfeel and a fuller flavor profile.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  4500 mg/kg
Farmakologiya i Toksikologiya Vol. 42, Pg. 274, 1979.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor enhancers, salt substitute
Recommendation for monopotassium glutamate usage levels up to:
 not for fragrance use.
 
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety of the change in the production method of L-glutamic acid (E620), monosodium L-glutamate (E621), monopotassium L-glutamate (E622), calcium di-L-glutamate (E623), monoammonium L-glutamate (E624) and magnesium di-L-glutamate (E625)
View page or View pdf
Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 19473-49-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23669634
National Institute of Allergy and Infectious Diseases: Data
 potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate
Chemidplus: 0019473495
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References:
 potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 19473-49-5
Pubchem (cid): 23669634
Pubchem (sid): 135019167
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): Search
FooDB: FDB020321
FDA Listing of Food Additive Status: View
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
L-glutamic acid potassium salt (1:1)
laevo-glutamic acid potassium salt (1:1)
 potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate
 potassium diglutamate
monopotassium L-glutamate
monopotassium laevo-glutamate
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Articles:
Google Patents: Potassium chloride, glutamic acid, monopotassium glutamate, potassium citrate, potassium phosphate
PubMed: Mice Perceive Synergistic Umami Mixtures as Tasting Sweet.
J-Stage: Evaluation of the Suppressive Effect on Bitter Taste of Gluconate
PubMed: Gustatory modulation of the responses of trigeminal subnucleus caudalis neurons to noxious stimulation of the tongue in rats.
PubMed: Speed and accuracy of taste identification and palatability: impact of learning, reward expectancy, and consummatory licking.
PubMed: Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa.
PubMed: Sweet-bitter and umami-bitter taste interactions in single parabrachial neurons in C57BL/6J mice.
PubMed: Umami taste in mice uses multiple receptors and transduction pathways.
PubMed: Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice.
PubMed: Taste preference and nerve response to 5'-inosine monophosphate are enhanced by glutathione in mice.
PubMed: Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.
PubMed: Response properties of the pharyngeal branch of the glossopharyngeal nerve for umami taste in mice and rats.
PubMed: Umami taste responses are mediated by alpha-transducin and alpha-gustducin.
PubMed: Taste of glutamate salts in young and elderly subjects: role of inosine 5'-monophosphate and ions.
PubMed: Taste effectiveness of glutamate compounds with different cations in rat.
PubMed: Glutamate neurotoxicity in culture depends on the presence of glutamine: implications for the role of glial cells in normal and pathological brain development.
PubMed: High-performance liquid chromatographic assay for pteroylpolyglutamate hydrolase.
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