lactalbumin
colostrum
 
Notes:
tsca definition 2008: a protein, belonging to the albumins, derived from milk.
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CAS Number: 9013-90-5 
ECHA EC Number: 232-750-1
MDL: MFCD00130492
Formula: unspecified
Category: special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 763 Alpha-lactalbumin View - notice PDF
GRN 809 Fractionated whey protein concentrate containing 41% alpha-lactalbumin View - notice PDF
GRN 909 Whey protein containing 41% alpha-lactalbumin View - notice PDF
FDA Mainterm (SATF):9013-90-5 ; LACTALBUMIN
FDA Regulation:
FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.111 Acidified milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.112 Cultured milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.170 Eggnog.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.200 Yogurt.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.203 Lowfat yogurt.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.206 Nonfat yogurt.
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
skin protecting agents
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Suppliers:
American Laboratories
Bovine Colostrum Powder W150
American Laboratories
Colostrum 15% IgG Powder 819
American Laboratories
Colostrum 20% IgG Powder 774
American Laboratories
Colostrum 30% IgG Powder 720
American Laboratories
Colostrum 30% IgG Powder 826
American Laboratories
Colostrum 40% IgG Powder 994
American Laboratories
Colostrum 9% IgG Powder 691
Maypro Industries
Colostrum
Pangaea Sciences
Colostrum
Sigma-Aldrich: Sigma
For experimental / research use only.
Lactalbumin
Silver Fern Chemical
Colostrum Powder
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for lactalbumin usage levels up to:
 not for fragrance use.
 
Recommendation for lactalbumin flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 9013-90-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0009013905
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References:
Canada Domestic Sub. List: 9013-90-5
Pubchem (sid): 135340269
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 colostrum
 lactalbumin
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Articles:
PubMed: Nanotubular structures developed from whey-based α-lactalbumin fractions for food applications.
J-Stage: Comparison of the Efficacy of Alpha-Lactalbumin from Equine, Bovine, and Human Milk in the Growth of Intestinal IEC-6 Cells
PubMed: [The effect of natural whey proteins on mechanisms of blood pressure regulation].
PubMed: [The effect of natural whey proteins on mechanisms of blood pressure regulation].
PubMed: Spermine Sepharose as a clustered-charge anion exchange adsorbent.
PubMed: Effects of Lactobacillus gasseri OLL2809 and α-lactalbumin on university-student athletes: a randomized, double-blind, placebo-controlled clinical trial.
PubMed: Inhibition of dipeptidyl peptidase (DPP)-IV and α-glucosidase activities by pepsin-treated whey proteins.
PubMed: Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): unique and shared effects on signaling and death.
PubMed: Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes.
PubMed: Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins.
PubMed: A molecular complex of bovine milk protein and oleic acid selectively kills cancer cells in vitro and inhibits tumour growth in an orthotopic rat bladder tumour model.
PubMed: Comprehensive assessment of milk composition in transgenic cloned cattle.
PubMed: Structural insights into the stability perturbations induced by N-terminal variation in human and goat α-lactalbumin.
PubMed: Global and local indices for characterizing biomolecular flexibility and rigidity.
PubMed: Characterizing natural colloidal/particulate-protein interactions using fluorescence-based techniques and principal component analysis.
PubMed: The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents.
PubMed: A synthetic garden of state of the art natural protein nanoarchitectures dispersed in nanofluids.
PubMed: A novel method for preparation of HAMLET-like protein complexes.
PubMed: Acceleration of protein aggregation by amphiphilic peptides: transformation of supramolecular structure of the aggregates.
PubMed: Selection of possible marker peptides for the detection of major ruminant milk proteins in food by liquid chromatography-tandem mass spectrometry.
PubMed: Fibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus.
PubMed: Improvement of the antimicrobial and antioxidant activities of camel and bovine whey proteins by limited proteolysis.
PubMed: Different folding pathways taken by highly homologous proteins, goat alpha-lactalbumin and canine milk lysozyme.
PubMed: A bovine whey protein extract stimulates human neutrophils to generate bioactive IL-1Ra through a NF-kappaB- and MAPK-dependent mechanism.
PubMed: Molecular and biotechnological advances in milk proteins in relation to human health.
PubMed: Interaction of antitumor alpha-lactalbumin-oleic acid complexes with artificial and natural membranes.
PubMed: Novel functions of bovine milk-derived alpha-lactalbumin: anti-nociceptive and anti-inflammatory activity caused by inhibiting cyclooxygenase-2 and phospholipase A2.
PubMed: Expression and characterization of bioactive recombinant human alpha-lactalbumin in the milk of transgenic cloned cows.
PubMed: Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics.
PubMed: Update on optimized purification and characterization of natural milk allergens.
PubMed: Effect of alpha-lactalbumin on aerosol-OT phase structures in oil/water mixtures.
PubMed: Role of intermolecular forces in defining material properties of protein nanofibrils.
PubMed: Construction and characterization of a Lipotes vexillifer genomic DNA BAC library.
PubMed: A role for milk proteins and their peptides in cancer prevention.
PubMed: Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
PubMed: Effect of the pH of heating on the qualitative and quantitative compositions of the sera of reconstituted skim milks and on the mechanisms of formation of soluble aggregates.
PubMed: Emerging therapeutic potential of whey proteins and peptides.
PubMed: alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.
PubMed: On the complexation of proteins and polyelectrolytes.
PubMed: Continuous matrix assisted refolding of alpha-lactalbumin by ion exchange chromatography with recycling of aggregates combined with ultradiafiltration.
PubMed: Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins.
PubMed: Matrix assisted refolding of proteins by ion exchange chromatography.
PubMed: Preparation of antioxidant enzymatic hydrolysates from alpha-lactalbumin and beta-lactoglobulin. Identification of active peptides by HPLC-MS/MS.
PubMed: R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable.
PubMed: Effect of pH and ionic strength on competitive protein adsorption to air/water interfaces in aqueous foams made with mixed milk proteins.
PubMed: Conformation-dependent interaction of alpha-lactalbumin with model and biological membranes: a spin-label ESR study.
PubMed: Structures and relative free energies of partially folded states of proteins.
PubMed: Use of cell culture media for cultivation of the mite pathogenic fungi Neozygites tanajoae and Neozygites floridana.
PubMed: Autoimmune enteropathy and colitis in an adult patient.
PubMed: The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification.
PubMed: Antimicrobial peptides from food proteins.
PubMed: Structural analysis, identification, and design of calcium-binding sites in proteins.
PubMed: Plasma Trp/LNAA ratio increases during chronic ingestion of an alpha-lactalbumin diet in rats.
PubMed: Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro.
PubMed: Induced lactation in prepubertal Holstein heifers.
PubMed: Inhibitors of complement activity in human breast-milk: a proposed hypothesis of their physiological significance.
PubMed: Selective degradation of unfolded proteins by the self-compartmentalizing HtrA protease, a periplasmic heat shock protein in Escherichia coli.
PubMed: Structural and thermodynamic responses of mutations at a Ca2+ binding site engineered into human lysozyme.
PubMed: The heat-shock protein HslVU from Escherichia coli is a protein-activated ATPase as well as an ATP-dependent proteinase.
PubMed: Effects of purified bovine whey factors on cellular immune functions in ruminants.
PubMed: Production of correctly folded recombinant [13C, 15N]-enriched guinea pig [Val90]-alpha-lactalbumin.
PubMed: Purification and characterization of protease Ci, a cytoplasmic metalloendoprotease in Escherichia coli.
PubMed: Large-scale production of a soluble human beta-1,4-galactosyltransferase using a Saccharomyces cerevisiae expression system.
PubMed: Purification and characterization of a poly-L-lysine-activated serine endoprotease from Lumbricus rubellus.
PubMed: In-vitro co-culture of early stage caprine embryos with oviduct and uterine epithelial cells.
PubMed: Collagenase secretion accompanying changes in cell shape occurs only in the presence of a biologically active cytokine.
PubMed: Proliferative and secretory activity in human breast during natural and artificial menstrual cycles.
PubMed: Cationic activation of galactosyltransferase from rat mammary Golgi membranes by polyamines and by basic peptides and proteins.
PubMed: New protein kinase from plasma membrane of Ehrlich ascites tumor cells activated by natural polypeptides.
PubMed: Energy/protein interrelation in experimental food restriction.
PubMed: Nutritional evaluations of three dietary levels of lactalbumin throughout the lifespan of two generations of Syrian hamsters.
PubMed: Changes in lactoferrin, immunoglobulin G, bovine serum albumin, and alpha-lactalbumin during acute experimental and natural coliform mastitis in cows.
PubMed: Environmental degradation of the insect growth regulator methoprene. VIII. Boving metabolism to natural products in mild and blood.
PubMed: A fluorimetric study of the interactions of insolubilized human alpha-lactalbumin with galactosyl transferase (A-protein) and with anti-alpha-lactalbumin antibodies.
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