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Category: sweeteners, bulking agents, anticaking agents, glazing agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 788.53 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 807.00 °F. TCC ( 430.70 °C. ) (est)
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| logP (o/w): | -4.907 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) | | | alcohol, very slightly |
Organoleptic Properties:
Odor Description: at 100.00 %. | odorless |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| American International Chemical, LLC. |
| Isomalt (galenIQ™)
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| Anhui Haibei |
| isoMalt
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| BOC Sciences |
| For experimental / research use only. |
| Isomalt
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| Cargill, Inc. |
| Isomaltidex® isomalt
Flavor: characteristic Isomalt polyol sweeteners have low hygroscopicity, very low cooling effect, provides bulk, texture and it provides the preservative benefits of sucrose in sugar-free and calorie-reduced products. |
| ECSA Chemicals |
| ISOMALT
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| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| Foodchem International |
| isoMalt
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| Glentham Life Sciences |
| Palatinitol
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| Nactis Flavours |
| Isomalt
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| O'Laughlin Industries |
| ISOMALTOLIN
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| Sinofi Food Ingredients |
| Isomalt
Flavor: characteristic Sugar Substitutes, Chewing Gum, Dairy Products, Confections, Candies, Baking Food, Soft Drink, Yogurt, Desserts, Alcoholic Beverages, Instant Coffee, Ice Cream, Anticaking Agent, Bulking Agent, Glazing Agent, Pharmaceutical. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | sweeteners, bulking agents, anticaking agents, glazing agents |
| Recommendation for isomalt usage levels up to: | | | not for fragrance use.
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| Recommendation for isomalt flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 3034828 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol |
| Chemidplus: | 0064519820 |
| RTECS: | LZ4394500 for cas# 64519-82-0 |
References:
| | (3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 3034828 |
| Pubchem (sid): | 135066178 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 6-O-alpha-D- | glucopyranosyl-D-glucitol mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol | | iso | maltitol | | hydrogenated iso | maltulose | | | palatinit | | (3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5- | trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol |
Articles:
| PubMed: | Effects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial. |
| PubMed: | Comparative dissolution study of drug and inert isomalt based core material from layered pellets. |
| PubMed: | Impact of fillers on dissolution kinetic of fenofibrate dry foams. |
| PubMed: | Formulation development and evaluation of metformin chewing gum with bitter taste masking. |
| PubMed: | Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin. |
| PubMed: | Potential intakes of total polyols based on UK usage survey data. |
| PubMed: | Supramolecular elucidation of the quality attributes of microcrystalline cellulose and isomalt composite pellet cores. |
| PubMed: | Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial. |
| PubMed: | Preparation, Characterization and Stability Studies of Glassy Solid Dispersions of Indomethacin using PVP and Isomalt as carriers. |
| PubMed: | Deformation properties of pharmaceutical excipients determined using an in-die and out-die method. |
| PubMed: | Assessment of isomalt for colon-specific delivery and its comparison with lactulose. |
| PubMed: | Evaluation of a sieve classification method for characterization of low-dose interactive mixtures. |
| PubMed: | Freeze-thaw stability of duck surimi-like materials with different cryoprotectants added. |
| PubMed: | Dissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt. |
| PubMed: | Compaction behavior of isomalt after roll compaction. |
| PubMed: | Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. |
| PubMed: | Energy evaluation of the compaction process of directly compressible isomalt. |
| PubMed: | Frozen yogurt with added inulin and isomalt. |
| PubMed: | A pilot human pharmacokinetic study and influence of formulation factors on orodispersible tablet incorporating meloxicam solid dispersion using factorial design. |
| PubMed: | Evaluation of drug release from coated pellets based on isomalt, sugar, and microcrystalline cellulose inert cores. |
| PubMed: | Evaluation of certain food additives. |
| PubMed: | Casein phosphopeptide-amorphous calcium phosphate incorporated into sugar confections inhibits the progression of enamel subsurface lesions in situ. |
| PubMed: | Multimodality vascular imaging phantoms: a new material for the fabrication of realistic 3D vessel geometries. |
| PubMed: | Improved metabolic control after 12-week dietary intervention with low glycaemic isomalt in patients with type 2 diabetes mellitus. |
| PubMed: | Acidogenic potential of "sugar-free" cough drops. |
| PubMed: | Compaction properties of isomalt. |
| PubMed: | Polyols as filler-binders for disintegrating tablets prepared by direct compaction. |
| PubMed: | Isomalt production by cloning, purifying and expressing of the MDH gene from Pseudomonas fluorescens DSM 50106 in different strains of E. coli. |
| PubMed: | Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of alpha-glucosylsaccharides in the small intestine. |
| PubMed: | Effects of Isomalt on enamel de- and remineralization, a combined in vitro pH-cycling model and in situ study. |
| PubMed: | Human rectal mucosal gene expression after consumption of digestible and non-digestible carbohydrates. |
| PubMed: | Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers. |
| PubMed: | Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers. |
| PubMed: | Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects? |
| PubMed: | Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. |
| PubMed: | [A new cause of false positives when analyzing expired air carbon monoxide]. |
| PubMed: | Bioavailability of hydrochlorothiazide from isomalt-based moulded tablets. |
| PubMed: | [Use of a new sugar substitute, erithritol, in the diet therapy of type 2 diabetes patients]. |
| PubMed: | [Comparative study of postprandial glycaemia in type 2 diabetic patients after consumption of mono- and disaccharides and sweeteners]. |
| PubMed: | The comparative gastrointestinal responses of children and adults following consumption of sweets formulated with sucrose, isomalt and lycasin HBC. |
| PubMed: | Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro. |
| PubMed: | The comparative gastrointestinal response of young children to the ingestion of 25 g sweets containing sucrose or isomalt. |
| PubMed: | Direct compression and moulding properties of co-extruded isomalt/drug mixtures. |
| PubMed: | Direct compression properties of melt-extruded isomalt. |
| PubMed: | What clients need to know about sugar replacers. |
| PubMed: | [Effect of mixing of fine carrier particles on dry powder inhalation property of salbutamol sulfate (SS)]. |
| PubMed: | Characterization and evaluation of isomalt performance in direct compression. |
| PubMed: | Bowel function in runners after ingestion of sweeteners. |
| PubMed: | Separation of alditols of interest in food products by high-performance anion-exchange chromatography with pulsed amperometric detection. |
| PubMed: | The effects of isomaltulose, isomalt, and isomaltulose-based oligomers on mineral absorption and retention. |
| PubMed: | Laboratory studies of sweets re-formulated to improve their dental properties. |
| PubMed: | Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate. |
| PubMed: | Variations of the enzymatic activity of the rat's gum glycolytic cycle following administration of sweeteners. |
| PubMed: | Bitterness of sweeteners as a function of concentration. |
| PubMed: | Digestion and absorption of sorbitol, maltitol and isomalt from the small bowel. A study in ileostomy subjects. |
| PubMed: | Dose dependency of fermentation and the extent of renal excretion of palatinit (isomalt) in rats with respect to its energy value. |
| PubMed: | Breath hydrogen after ingestion of the bulk sweeteners sorbitol, isomalt and sucrose in chocolate. |
| PubMed: | Clinical caries studies with polyalcohols. A literature review. |
| PubMed: | 'Determination' of sugar alcohol and Polydextrose absorption in humans by the breath hydrogen (H2) technique: the stoichiometry of hydrogen production and the interaction between carbohydrates assessed in vivo and in vitro. |
| PubMed: | The digestion process of the sugar alcohol isomalt in the intestinal tract of the pig. 2. Studies with administration of isomalt as a sweet. |
| PubMed: | The digestion process of the sugar alcohol isomalt in the intestinal tract of the pig. 1. Studies with administration of isomalt in the feed. |
| PubMed: | Efficacy of sweeteners and sugar substitutes in caries prevention. |
| PubMed: | Comparative studies of gastrointestinal tolerance and acceptability of milk chocolate containing either sucrose, isomalt or sorbitol in healthy consumers and type II diabetics. |
| PubMed: | Effects of conventional sucrose-based, fructose-based and isomalt-based chocolates on postprandial metabolism in non-insulin-dependent diabetics. |
| PubMed: | [Clinical tolerance, intestinal absorption, and energy value of four sugar alcohols taken on an empty stomach]. |
| PubMed: | Analysis of Palatinit (isomalt) and its monomers in rat intestinal samples by high-performance liquid chromatography with ultraviolet detection. |
| PubMed: | Chronic toxicity and carcinogenicity study of isomalt in rats and mice. |
| PubMed: | Embryotoxicity/teratogenicity of isomalt in rats and rabbits. |
| PubMed: | Multigeneration reproduction study of isomalt in rats. |
| PubMed: | Hydrogen excretion after ingestion of five different sugar alcohols and lactulose. |
| PubMed: | Developmental toxicity of isomalt in rats. |
| PubMed: | [Current and future prospects concerning the prevention of dental caries]. |
| PubMed: | [Stepwise study procedure of sugar substitutes--preliminary study with enzymes. 4. Glucosyltransferases of Streptococcus mutans AHT]. |
| PubMed: | Relationship between carbohydrate sweeteners and oral diseases. |
| PubMed: | [Dose dependence of the energy utilization of sugar substitutes]. |
| PubMed: | Sugar substitutes and their energy value for the human body. |
| PubMed: | [Energy utilization of Palatinit]. |
| PubMed: | [Sugar substitutes--new substances]. |
| PubMed: | Hydrolysis of lactitol, maltitol and Palatinit by human intestinal biopsies. |
| PubMed: | On the occurrence of free glucose in the caecal contents of rats. |
| PubMed: | Microcalorimetric investigation into the metabolic activity of rat caecal flora in the presence of different sugars and sugar substitutes. |
| PubMed: | [Utilization of the sugar substitute Palatinit in metabolism]. |
| PubMed: | Dose dependence of breath hydrogen and methane in healthy volunteers after ingestion of a commercial disaccharide mixture, Palatinit. |
| PubMed: | Sweeteners and dental health. |
| PubMed: | Microbiological aspects of some caloric sugar substitutes. |
| PubMed: | The effect of sweeteners on acid production in plaque. |
| PubMed: | Comparative study of isomalt and sucrose by means of continuous indirect calorimetry. |
| PubMed: | [Palatinit--digestibility and energy utilization in model experiments with sows]. |
| PubMed: | Bioavailability of glucose from Palatinit. |
| PubMed: | [Energy metabolism and insulin activity in rats after Palatinit administration]. |
| PubMed: | [Palatinite in type II diabetics. Effect on blood-glucose, serum-insulin, C-peptide and free fatty acids]. |
| PubMed: | [Energetic utilization of Palatinit]. |
| PubMed: | [Anaerobic transformation of Palatinit by microorganisms of the human oral cavity]. |
| PubMed: | [Palatinit and xylitol in a gnotobiotic rat experiment]. |
| PubMed: | [Sweetening agent, Palatinit under specific consideration as to microbiological and caries-prophylactic aspects]. |
| PubMed: | [Studies on cariogenicity of sugar substitutes in xerostomized rats]. |
| PubMed: | [Analytical characterization of palatinit (author's transl)]. |
| PubMed: | [Palatinite--a new sugar substitute and its caries prophylactic evaluation]. |
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