glucose isomerase from streptomyces rubiginosus
xylose isomerase from streptomyces rubiginosus
 
Notes:
Used as a food additive [EAFUS]
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FDA internal no.: 977090-06-4 
Category: enzyme preparations and microorganisms
 
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JECFA Food Additive: Glucose Isomerase from Streptomyces rubiginosus
FDA Mainterm (SATF):977090-06-4 ; GLUCOSE ISOMERASE FROM STREPTOMYCES RUBIGINOSUS
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1372 Insoluble glucose isomerase enzyme preparations.
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Physical Properties:
Appearance: whit to brown granules or liquid (est)
Food Chemicals Codex Listed: No
Insoluble in:
 alcohol
 water
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: enzyme preparations and microorganisms
Recommendation for glucose isomerase from streptomyces rubiginosus usage levels up to:
 not for fragrance use.
 
Recommendation for glucose isomerase from streptomyces rubiginosus flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Safety evaluation of the food enzyme xylose isomerase from the genetically modified Streptomyces rubiginosus strain DP-Pzn37
View page or View pdf
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0977090064
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References:
Pubchem (sid): 135353155
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): HMDB32295
FooDB: FDB009499
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 glucose isomerase
Search  PMC Picture
 streptomyces rubiginosus
Search  PMC Picture
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Synonyms:
 xylose isomerase from streptomyces rubiginosus
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Articles:
PubMed: Engineering acidic Streptomyces rubiginosus D-xylose isomerase by rational enzyme design.
PubMed: A common mechanism underlying amyloid fibrillation and protein crystallization revealed by the effects of ultrasonication.
PubMed: Role of invariant water molecules and water-mediated ionic interactions in D-xylose isomerase from Streptomyces rubiginosus.
PubMed: An innovative biocatalyst for production of ethanol from xylose in a continuous bioreactor.
PubMed: Thermoinactivation mechanism of glucose isomerase.
PubMed: Characterization of the pH-dependent dissociation of a multimeric metalloprotein Streptomyces rubiginosus xylose isomerase by ESI FT-ICR mass spectrometry.
PubMed: Cryogenic (<20 K) helium cooling mitigates radiation damage to protein crystals.
PubMed: Locating active-site hydrogen atoms in D-xylose isomerase: time-of-flight neutron diffraction.
PubMed: A quasi-Laue neutron crystallographic study of D-xylose isomerase.
PubMed: Direct comparison of the crystal and solution structure of glucose/xylose isomerase from Streptomyces rubiginosus.
PubMed: Engineering the substrate specificity of xylose isomerase.
PubMed: Chromatographic separation of nucleosides using a cross-linked xylose isomerase crystal stationary phase.
PubMed: A preliminary time-of-flight neutron diffraction study of Streptomyces rubiginosus D-xylose isomerase.
PubMed: SAD manganese in two crystal forms of glucose isomerase.
PubMed: Simultaneous catalysis and product separation by cross-linked enzyme crystals.
PubMed: Stability of native and cross-linked crystalline glucose isomerase.
PubMed: Lowering the pH optimum of D-xylose isomerase: the effect of mutations of the negatively charged residues.
PubMed: Extranuclear expression of the bacterial xylose isomerase (xylA) and the UDP-glucose dehydrogenase (hasB) genes in yeast with Kluyveromyces lactis linear killer plasmids as vectors.
PubMed: Probing the roles of active site residues in D-xylose isomerase.
PubMed: A structural role for arginine in proteins: multiple hydrogen bonds to backbone carbonyl oxygens.
PubMed: Perturbing the metal site in D-xylose isomerase. Effect of mutations of His-220 on enzyme stability.
PubMed: X- and Q-band EPR studies on the two Mn(2+)-substituted metal-binding sites of D-xylose isomerase.
PubMed: Genetic organization and regulation of the xylose degradation genes in Streptomyces rubiginosus.
PubMed: Visible, EPR and electron nuclear double-resonance spectroscopic studies on the two metal-binding sites of oxovanadium (IV)-substituted D-xylose isomerase.
PubMed: A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 A Streptomyces rubiginosus structures with xylitol and D-xylose.
PubMed: Spectroscopic studies on the metal-ion-binding sites of Co2(+)-substituted D-xylose isomerase from Streptomyces rubiginosus.
PubMed: Localization of the essential histidine and carboxylate group in D-xylose isomerases.
PubMed: X-ray analysis of D-xylose isomerase at 1.9 A: native enzyme in complex with substrate and with a mechanism-designed inactivator.
PubMed: Comparison of backbone structures of glucose isomerase from Streptomyces and Arthrobacter.
PubMed: X-ray crystal structure of D-xylose isomerase at 4-A resolution.
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