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Category: carrier solvents, encapsulating agent for food additives, flavorings, stabilizers and absorbents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline solid (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 278.00 °C. @ 760.00 mm Hg
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| logP (o/w): | -6.550 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) | | | alcohol, very slightly |
Organoleptic Properties:
Odor Description: at 100.00 %. | odorless |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-rat LD50 788 mg/kg American Journal of Pathology. Vol. 83, Pg. 367, 1976.
intraperitoneal-rat LD50 1000 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 287, 1983.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | carrier solvents, encapsulating agent for food additives, flavorings, stabilizers and absorbents |
| Recommendation for alpha-cyclodextrin usage levels up to: | | | not for fragrance use.
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| Recommendation for alpha-cyclodextrin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | alfadex | | | alfadexum | | alpha- | cycloamylase | | alpha- | cycloamylose | | alpha- | schardinger dextrin |
Articles:
| PubMed: | Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice. |
| PubMed: | The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes. |
| PubMed: | Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying. |
| PubMed: | Cyclodextrin encapsulation to prevent the loss of l-menthol and its retention during drying. |
| PubMed: | Mutations enhance β-cyclodextrin specificity of cyclodextrin glycosyltransferase from Bacillus circulans. |
| PubMed: | An experimental design based strategy to optimize a capillary electrophoresis method for the separation of 19 polycyclic aromatic hydrocarbons. |
| PubMed: | Transglycosylation of engineered cyclodextrin glucanotransferases as O-glycoligases. |
| PubMed: | Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo. |
| PubMed: | Calcium ion contribution to thermostability of cyclodextrin glycosyltransferase is closely related to calcium-binding site CaIII. |
| PubMed: | Molecular cloning and enzymatic characterization of cyclomaltodextrinase from hyperthermophilic archaeon Thermococcus sp. CL1. |
| PubMed: | Intravenous topiramate: comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers. |
| PubMed: | Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography. |
| PubMed: | Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins. |
| PubMed: | An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex. |
| PubMed: | Production of α-cyclodextrin glycosyltransferase in Bacillus megaterium MS941 by systematic codon usage optimization. |
| PubMed: | Enhanced mineralization of diuron using a cyclodextrin-based bioremediation technology. |
| PubMed: | Sorption of ochratoxin A from aqueous solutions using β-cyclodextrin-polyurethane polymer. |
| PubMed: | In vitro and in vivo characterization of amorphous, nanocrystalline, and crystalline ziprasidone formulations. |
| PubMed: | Encapsulation of ethylene gas into α-cyclodextrin and characterisation of the inclusion complexes. |
| PubMed: | [Enhanced storage stability of recombinant enzyme preparation of alpha-CGTase from Paenibacillus macerans by chemical additives]. |
| PubMed: | High-level extracellular production of α-cyclodextrin glycosyltransferase with recombinant Escherichia coli BL21 (DE3). |
| PubMed: | Extracellular expression and biochemical characterization of alpha-cyclodextrin glycosyltransferase from Paenibacillus macerans. |
| PubMed: | Effect of alpha-cyclodextrin-cinnamic acid inclusion complexes on populations of Escherichia coli O157:H7 and Salmonella enterica in fruit juices. |
| PubMed: | Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice. |
| PubMed: | Mutations of Lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhance beta-cyclodextrin specificity. |
| PubMed: | Delayed supplementation of glycine enhances extracellular secretion of the recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli. |
| PubMed: | Calcium leads to further increase in glycine-enhanced extracellular secretion of recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli. |
| PubMed: | Mutations at subsite -3 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhancing alpha-cyclodextrin specificity. |
| PubMed: | Kinetics of molecular encapsulation of 1-methylcyclopropene into alpha-cyclodextrin. |
| PubMed: | Release of 1-methylcyclopropene from heat-pressed polymer films. |
| PubMed: | Changes in the catalytic properties of Pyrococcus furiosus thermostable amylase by mutagenesis of the substrate binding sites. |
| PubMed: | Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys. |
| PubMed: | Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome. |
| PubMed: | Stereoisomeric distribution of 3-mercaptohexan-1-ol and 3-mercaptohexyl acetate in dry and sweet white wines made from Vitis vinifera (Var. Sauvignon Blanc and Semillon). |
| PubMed: | Retention of a European pear aroma model mixture using different types of saccharides. |
| PubMed: | Cyclodextrin (CD) complexes of cholesterol--their potential use in reducing dietary cholesterol intake. |
| PubMed: | The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats. |
| PubMed: | Evaluation of certain food additives. |
| PubMed: | The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes. |
| PubMed: | Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme. |
| PubMed: | Disposition of 14C-alpha-cyclodextrin in germ-free and conventional rats. |
| PubMed: | Safety evaluation of an alpha-cyclodextrin glycosyltranferase preparation. |
| PubMed: | Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rabbits. |
| PubMed: | Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rats. |
| PubMed: | Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs. |
| PubMed: | Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying. |
| PubMed: | Paenibacillus stellifer sp. nov., a cyclodextrin-producing species isolated from paperboard. |
| PubMed: | Evaluation of certain food additives and contaminants. |
| PubMed: | Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria. |
| PubMed: | Inclusion complex of conjugated linoleic acid (CLA) with cyclodextrins. |
| PubMed: | Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis. |
| PubMed: | Hydrolytic action of alpha-amylase on high-amylose starch of low molecular mass. |
| PubMed: | Enantiomeric purity and odor characteristics of 2- and 3-acetoxy-1, 8-cineoles in the rhizomes of Alpinia galanga willd. |
| PubMed: | Cloning and sequencing of a cyclodextrin glycosyltransferase gene from Brevibacillus brevis CD162 and its expression in Escherichia coli. |
| PubMed: | Crystal structure of recombinant soybean beta-amylase complexed with beta-cyclodextrin. |
| PubMed: | Comparison of the binding of beta-cyclodextrin and alpha- and gamma-cyclodextrins with pullulanase from Klebsiella pneumoniae as studied by equilibrium and kinetic fluorometry. |
| PubMed: | Two sulfhydryl groups near the active site of soybean beta-amylase. |
| PubMed: | Affinity purification of beta-amylases originating from plant using cyclomaltohexaose-immobilized Sepharose 6B in the presence of ammonium sulfate. |
| PubMed: | Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins. |
| PubMed: | Expression and mutation of soybean beta-amylase in Escherichia coli. |
| PubMed: | Interaction between pullulanase from Klebsiella pneumoniae and cyclodextrins. |
| PubMed: | Effect of some constituents of chicken egg yolk lipoprotein on the growth and IgM production of human-human hybridoma cells and other human-derived cells. |
| PubMed: | Three-dimensional structure of soybean beta-amylase determined at 3.0 A resolution: preliminary chain tracing of the complex with alpha-cyclodextrin. |
| PubMed: | Affinity labeling of a subsite of Taka-amylase A by the fluorescent reagent o-phthalaldehyde. |
| PubMed: | Repeating use of Chalara paradoxa amylase by alpha-cyclodextrin affinity column. |
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