asparaginase from aspergillus oryzae expressed in aspergillus oryzae
 
Notes:
nci: an enzyme isolated from the bacterium escherichia coli or the bacterium erwinia carotovora with antileukemic activity. asparaginase hydrolyzes l-asparagine to l-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the g1 phase, and apoptosis in susceptible leukemic cell populations. see more at nci
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CAS Number: 9015-68-3 
ECHA EC Number: 232-765-3
Formula: unspecified
Category: enzyme preparations and microorganisms
 
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 201 Asparaginase enzyme preparation from Aspergillus oryzae expressing the asparaginase gene from A. oryzae View - notice PDF
JECFA Food Additive: Asparaginase from Aspergillus oryzae expressed in A. oryzae
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  7500 ul/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 919, 1971.

intravenous-rat LD50  7568 mg/kg
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.

intraperitoneal-rat LD50  8204 mg/kg
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.

intravenous-rabbit LD50  2.273 mg/kg
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.

Dermal Toxicity:
subcutaneous-rat LD50 8204 mg/kg
Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: enzyme preparations and microorganisms
Recommendation for asparaginase from aspergillus oryzae expressed in aspergillus oryzae usage levels up to:
 not for fragrance use.
 
Recommendation for asparaginase from aspergillus oryzae expressed in aspergillus oryzae flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0009015683
EPA/NOAA CAMEO: hazardous materials
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References:
Pubchem (sid): 135362876
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Other Information:
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
MedlinePlusSupp: View
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 asparaginase
Search  PMC Picture
 aspergillus oryzae
Search  PMC Picture
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Synonyms:
 asparaginase from aspergillus oryzae expressed in aspergillus oryzae
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