Articles:
| None found yet. Try the PubMed Search. |
Notes:
nci: an enzyme isolated from the bacterium escherichia coli or the bacterium erwinia carotovora with antileukemic activity. asparaginase hydrolyzes l-asparagine to l-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the g1 phase, and apoptosis in susceptible leukemic cell populations. see more at nci
-
BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 9015-68-3 Leucogen;Asparaginase;Colaspase 95%
-
-
Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GX2339 L-Asparaginase
-
| CAS Number: | 9015-68-3 | |
| Other(deleted CASRN): | 9037-33-6 | |
| ECHA EC Number: | 232-765-3 | |
| FDA UNII: | G4FQ3CKY5R | |
| Formula: | unspecified | |
Category: enzyme preparations and microorganisms
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA/DG SANTE Petitions, Reviews, Notices: | |
| GRN 428 | Asparaginase enzyme preparation from genetically modified Aspergillus niger View - notice PDF |
| GRN 214 | Asparaginase enzyme preparation from Aspergillus niger expressing the asparaginase gene from A. niger View - notice PDF |
| JECFA Food Additive: | Asparaginase from Aspergillus niger expressed in A.niger |
Physical Properties:
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Leucogen;Asparaginase;Colaspase 95% |
| Glentham Life Sciences |
| L-Asparaginase |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 7500 ul/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 919, 1971. intravenous-rat LD50 7568 mg/kg Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969. intraperitoneal-rat LD50 8204 mg/kg Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969. intravenous-rabbit LD50 2.273 mg/kg Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969. | |
| Dermal Toxicity: | |
|
subcutaneous-rat LD50 8204 mg/kg Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 271, 1969. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | enzyme preparations and microorganisms | ||
| Recommendation for asparaginase from aspergillus niger expressed in aspergillus niger usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for asparaginase from aspergillus niger expressed in aspergillus niger flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Annual report on the preparatory work for the evaluation of food enzymes – Toxicological part View page or View pdf | |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| National Institute of Allergy and Infectious Diseases: | Data |
| Chemidplus: | 0009015683 |
| EPA/NOAA CAMEO: | hazardous materials |
References:
| Pubchem (sid): | 135362876 |
Other Information:
| HMDB (The Human Metabolome Database): | Search |
| FDA Listing of Food Additive Status: | View |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| Wikipedia: | View |
| Wikipedia2: | View2 |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| asparaginase Search PMC Picture | |
| asparaginase II Search PMC Picture | |
| asparagine amidohydrolase Search PMC Picture | |
| aspergillus niger Search PMC Picture |
Synonyms:
| alpha- | asparaginase |
| L- | asparaginase |
| laevo- | asparaginase |
| asparaginase enzyme preparation from genetically modified aspergillus niger | |
| asparaginase II | |
| L- | asparagine amidohydrolase |
| laevo- | asparagine amidohydrolase |