integerrimine, 480-79-5

Articles:

PubMed:	UPLC-MS/MS method for determination of selected pyrrolizidine alkaloids in feed.
PubMed:	Three new monoterpene glucosides from Senecio solidagineus.
PubMed:	Correction to Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid.
PubMed:	Toxicity of pyrrolizidine alkaloids to Spodoptera exigua using insect cell lines and injection bioassays.
PubMed:	Prenatal exposure to integerrimine N-oxide impaired the maternal care and the physical and behavioral development of offspring rats.
PubMed:	Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica.
PubMed:	Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid.
PubMed:	[Determination of five pyrrolizidine alkaloids in honey by liquid chromatography-tandem mass spectrometry].
PubMed:	Tusanqi and hepatic sinusoidal obstruction syndrome.
PubMed:	Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine.
PubMed:	Development and validation of a rapid multiplex ELISA for pyrrolizidine alkaloids and their N-oxides in honey and feed.
PubMed:	Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model.
PubMed:	Analysis of pyrrolizidine alkaloids and evaluation of some biological activities of Algerian Senecio delphinifolius (Asteraceae).
PubMed:	The relationship between structurally different pyrrolizidine alkaloids and western flower thrips resistance in F(2) hybrids of Jacobaea vulgaris and Jacobaea aquatica.
PubMed:	Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis.
PubMed:	[Simultaneous quantitation of adonifoline and senecionine in Senecio herbs by UPLC-MS].
PubMed:	Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS.
PubMed:	The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS.
PubMed:	Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.
PubMed:	The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury.
PubMed:	Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa.
PubMed:	[Ethyl acetate-soluble chemical constituents from whole plants of Senecio chrysanthemoides].
PubMed:	Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera).
PubMed:	Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids.
PubMed:	Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes.
PubMed:	Pyrrolizidine alkaloids in pollen and pollen products.
PubMed:	Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes.
PubMed:	Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera).
PubMed:	Simultaneous determination of senecionine, adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies.
PubMed:	Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry.
PubMed:	Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia.
PubMed:	Simultaneous characterization of pyrrolizidine alkaloids and N-oxides in Gynura segetum by liquid chromatography/ion trap mass spectrometry.
PubMed:	Safety assessment of food and herbal products containing hepatotoxic pyrrolizidine alkaloids: interlaboratory consistency and the importance of N-oxide determination.
PubMed:	Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes.
PubMed:	The toxicity of Senecio inaequidens DC.
PubMed:	Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang).
PubMed:	Identification and quantification of hepatotoxic pyrrolizidine alkaloids in the Ethiopian medicinal plant Solanecio gigas (Asteraceae).
PubMed:	Pyrrolizidine alkaloids of the endemic Mexican genus Pittocaulon and assignment of stereoisomeric 1,2-saturated necine bases.
PubMed:	Determination of pyrrolizidine alkaloids in senecio species by liquid chromatography/thermospray-mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy.
PubMed:	Pyrrolizidine alkaloid level in Senecio bicolor (Wilid.) Tod, ssp. cineraria (DC.) from middle Europe.
PubMed:	Dynamic pH junction-sweeping capillary electrophoresis for online preconcentration of toxic pyrrolizidine alkaloids in Chinese herbal medicine.
PubMed:	Do naïve ruminants degrade alkaloids in the rumen?
PubMed:	Acquisition, transformation and maintenance of plant pyrrolizidine alkaloids by the polyphagous arctiid Grammia geneura.
PubMed:	Separation and determination of toxic pyrrolizidine alkaloids in traditional Chinese herbal medicines by micellar electrokinetic chromatography with organic modifier.
PubMed:	Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
PubMed:	Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae).
PubMed:	Specific recognition, detoxification and metabolism of pyrrolizidine alkaloids by the polyphagous arctiid Estigmene acrea.
PubMed:	Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle genera.
PubMed:	Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.
PubMed:	Preventive activity of pyrrolizidine alkaloids from Seneciobrasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats.
PubMed:	Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers.
PubMed:	Differential metabolism of the pyrrolizidine alkaloid, senecionine, in Fischer 344 and Sprague-Dawley rats.
PubMed:	Acquired and partially de novo synthesized pyrrolizidine alkaloids in two polyphagous arctiids and the alkaloid profiles of their larval food-plants.
PubMed:	Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea.
PubMed:	Evaporative light scattering detection of pyrrolizidine alkaloids.
PubMed:	Taste receptors for pyrrolizidine alkaloids in a monophagous caterpillar.
PubMed:	Pyrrolizidine alkaloids as oviposition stimulants for the cinnabar moth, Tyria jacobaeae.
PubMed:	Uptake and metabolism of pyrrolizidine alkaloids in Longitarsus flea beetles (Coleoptera: Chrysomelidae) adapted and non-adapted to alkaloid-containing host plants.
PubMed:	Biochemical strategy of sequestration of pyrrolizidine alkaloids by adults and larvae of chrysomelid leaf beetles.
PubMed:	Toxicity of Senecio vernalis to laying hens and evaluation of residues in eggs.
PubMed:	Toxic pyrrolyzidine alkaloids from three mongolian plants. a possible risk for cattle poisoning.
PubMed:	Pyrrolizidine alkaloid profiles of some Senecio species from Egypt.
PubMed:	Structure-activity relationships of pyrrolizidine alkaloids in insect chemical defense against the orb-weaving spider Nephila clavipes.
PubMed:	Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography.
PubMed:	Alkaloids from Senecio aquaticus.
PubMed:	Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae.
PubMed:	Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years.
PubMed:	Interplant alkaloid variation and Senecio vernalis toxicity in cattle.
PubMed:	Defensive chemistry of Senecio miser.
PubMed:	Variability in chemical constituents in Petasites hybridus from Austria.
PubMed:	SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest).
PubMed:	Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island.
PubMed:	Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.
PubMed:	[Veno-occlusive disease after prolonged treatment with senecionine (Hemoluol)].
PubMed:	The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamsters.
PubMed:	Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine.
PubMed:	Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS.
PubMed:	The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids.
PubMed:	Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster.
PubMed:	Pyrrolizidine alkaloids from Gynura divaricata.
PubMed:	A competitive enzyme immunoassay for the pyrrolizidine alkaloids of the senecionine type.
PubMed:	Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography.
PubMed:	Enzyme-linked immunosorbent assay detection of pyrrolizidine alkaloids: immunogens based on quaternary pyrrolizidinium salts.
PubMed:	Pyrrolizidine alkaloids of three species of senecio in British Columbia.
PubMed:	A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig.
PubMed:	Analysis of pyrrolizidine alkaloids: a competitive enzyme-linked immunoassay (ELISA) for the quantitative determination of some toxic pyrrolizidine alkaloids.
PubMed:	The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs.
PubMed:	Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae).
PubMed:	Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo.
PubMed:	Structural influences on pyrrolizidine alkaloid-induced cytopathology.
PubMed:	Pyrrolizidine alkaloids from Senecio leucanthemifolius and Senecio rodriguezii.
PubMed:	Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine.
PubMed:	Hydrolysis of pyrrolizidine alkaloids by guinea pig hepatic carboxylesterases.
PubMed:	Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids.
PubMed:	Pyrrolizidine alkaloids from Werneria nubigena.
PubMed:	Pyrrolizidine alkaloids from Melampyrum pratense.
PubMed:	Sequestration of ingested [(14)C]senecionineN-oxide in the exocrine defensive secretions of chrysomelid beetles.
PubMed:	DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships.
PubMed:	Flavin-containing monooxygenase: a major detoxifying enzyme for the pyrrolizidine alkaloid senecionine in guinea pig tissues.
PubMed:	Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver.
PubMed:	Mechanisms for pyrrolizidine alkaloid activation and detoxification.
PubMed:	Excretion and blood radioactivity levels following [14C]senecionine administration in the rat.
PubMed:	N-acetylcysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine.
PubMed:	The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells.
PubMed:	Honeydew analysis for detecting phloem transport of plant natural products : Implications for host-plant resistance to sap-sucking insects.
PubMed:	[Studies on the alkaloids of Gynura segetum (Lour.) Merr].
PubMed:	Pyrrolizidine alkaloids in Senecio vulgaris L. growing in Iceland.
PubMed:	Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.
PubMed:	The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine.
PubMed:	Human embryotoxicity of pyrrolizidine-containing drugs.
PubMed:	Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes.
PubMed:	Sites of synthesis, translocation and accumulation of pyrrolizidine alkaloid N-oxides in Senecio vulgaris L.
PubMed:	Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L.
PubMed:	Metabolic links between the biosynthesis of pyrrolizidine alkaloids and polyamines in root cultures of Senecio vulgaris.
PubMed:	Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.
PubMed:	Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris.
PubMed:	Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.
PubMed:	Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea.
PubMed:	Livestock poisoning in South America by species of the Senecio plant.
PubMed:	Species differences in the hepatic microsomal metabolism of the pyrrolizidine alkaloid senecionine.
PubMed:	Alkaloid patterns and biosynthetic capacity of root cultures from some pyrrolizidine alkaloid producing Senecio species.
PubMed:	Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals.
PubMed:	Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats.
PubMed:	Microsomal metabolism of pyrrolizidine alkaloids: N-oxidation of seneciphylline and senecionine.
PubMed:	[Solvent extraction and isolation of alkaloids A and B from Senecio fuberi].
PubMed:	Metabolism and toxicity of anacrotine, a pyrrolizidine alkaloid, in rats.
PubMed:	Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenal trans-4-OH-2-hexenal.
PubMed:	Microsomal metabolism of pyrrolizidine alkaloids from Senecio jacobaea. Isolation and quantification of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine and N-oxides by high performance liquid chromatography.
PubMed:	Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals.
PubMed:	Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro.
PubMed:	Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants.
PubMed:	The formation of 6,7-dihydro-7-hydroxy-1-hydroxy-methyl-5H-pyrrolizine, a metabolite of pyrrolizidine alkaloids.
PubMed:	Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography.
PubMed:	Determination of pyrrolizidine alkaloids in Senecio inaequidens D.C. by capillary gas chromatography.
PubMed:	In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules.
PubMed:	Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins.
PubMed:	trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine.
PubMed:	Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine.
PubMed:	Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes.
PubMed:	In vivo covalent binding of retronecine-labelled [3H]seneciphylline and [3H]senecionine to DNA of rat liver, lung and kidney.
PubMed:	Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats.
PubMed:	Senecionine from Gynura segetum.
PubMed:	New guaianolides from Centaurea kandavanensis.
PubMed:	Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes.
PubMed:	Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.
PubMed:	Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues.
PubMed:	Comparison of the toxicities of Senecio jacobaea, Senecio vulgaris and Senecio glabellus in rats.
PubMed:	A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro.
PubMed:	Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice.
PubMed:	Carcinogenic and mutagenic activity of an alkaloidal extract of Senecio nemorensis ssp. fuchsii.
PubMed:	Alkaloids from Senecio aegyptius and S. desfontainei.
PubMed:	Metabolism, cytotoxicity, and genotoxicity of the pyrrolizidine alkaloid senecionine in primary cultures of rat hepatocytes.
PubMed:	Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on aminopyrine N-demethylase activity on the rat liver S-10 fraction.
PubMed:	[On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species].
PubMed:	[Spasmolytic properties of pyrrolizidine alkaloids].
PubMed:	Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.)
PubMed:	Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.
PubMed:	Senecionine, Seneciphylline, Jacobine and Otosenine from Senecio cineraria.
PubMed:	Pyrrolizidine alkaloid biosynthesis. Relative rates of incorporation of the isomers of isoleucine into the necic acid component of senecionine.
PubMed:	[Various biochemical changes in the rat liver following acute senecionine poisoning. I. Changes in content of reduced glutathione, plasma proteins and bilirubin].
PubMed:	Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.
PubMed:	Pharmacological properties of integerrimine, an alkaloid isolated from Crotalaria brevifolia.
PubMed:	Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis.
PubMed:	The action of alloxan, senecionine, sulfadiazine, and thiouracil in the hamster.
PubMed:	The effects of senecionine on the monkey.
PubMed:	Effects of senecionine on the hamster and monkey.