clivorine, 33979-15-6

Articles:

PubMed:	Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication.
PubMed:	Clivorine, an otonecine pyrrolizidine alkaloid from Ligularia species, impairs neuronal differentiation via NGF-induced signaling pathway in cultured PC12 cells.
PubMed:	The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity.
PubMed:	Quercetin prevents pyrrolizidine alkaloid clivorine-induced liver injury in mice by elevating body defense capacity.
PubMed:	Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model.
PubMed:	Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity.
PubMed:	The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury.
PubMed:	Pyrrolizidine alkaloid clivorine induced oxidative injury on primary cultured rat hepatocytes.
PubMed:	Pyrrolizidine alkaloid clivorine-induced oxidative stress injury in human normal liver L-02 cells.
PubMed:	Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity.
PubMed:	Protection of epidermal growth factor against clivorine-induced mitochondrial-mediated apoptosis in hepatocytes.
PubMed:	Protection of S-adenosyl methionine against the toxicity of clivorine on hepatocytes.
PubMed:	Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes.
PubMed:	Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
PubMed:	The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism.
PubMed:	Intracellular glutathione plays important roles in pyrrolizidine alkaloid clivorine-induced toxicity on L-02 hepatocytes.
PubMed:	In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.
PubMed:	Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes.
PubMed:	Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.
PubMed:	Pyrrolizidine alkaloid clivorine induces apoptosis in human normal liver L-02 cells and reduces the expression of p53 protein.
PubMed:	Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook.
PubMed:	Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat.
PubMed:	Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells.
PubMed:	Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine.
PubMed:	Simultaneous analysis of clivorine and its four microsomal metabolites by high-performance liquid chromatography.
PubMed:	Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid.
PubMed:	Characterization of two structural forms of otonecine-type pyrrolizidine alkaloids from Ligularia hodgsonii by NMR spectroscopy.
PubMed:	Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid.
PubMed:	A quantitative investigation of the transannular amine-ketone (N...C=O) interaction in medium-sized heterocycles.
PubMed:	Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes.
PubMed:	CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata.
PubMed:	Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test.