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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 42.86 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for norcarane usage levels up to: | | | not for fragrance use.
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| Recommendation for norcarane flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | bicyclo(4.1.0)heptane | | | bicyclo[4.1.0]heptane | | 1,2- | methylene cyclohexane | | 1,2- | methylenecyclohexane |
Articles:
| PubMed: | The Enigmatic P450 Decarboxylase OleT Is Capable of, but Evolved To Frustrate, Oxygen Rebound Chemistry. |
| PubMed: | Manganese Catalyzed C-H Halogenation. |
| PubMed: | Solution structures of lithium amino alkoxides used in highly enantioselective 1,2-additions. |
| PubMed: | Identity and mechanisms of alkane-oxidizing metalloenzymes from deep-sea hydrothermal vents. |
| PubMed: | Substrate specificity and reaction mechanism of purified alkane hydroxylase from the hydrocarbonoclastic bacterium Alcanivorax borkumensis (AbAlkB). |
| PubMed: | Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB. |
| PubMed: | Selective hydroxylation of alkanes by an extracellular fungal peroxygenase. |
| PubMed: | Manganese porphyrins catalyze selective C-H bond halogenations. |
| PubMed: | The effect of a complexed lithium cation on a norcarane-based radical clock. |
| PubMed: | Profiling mechanisms of alkane hydroxylase activity in vivo using the diagnostic substrate norcarane. |
| PubMed: | Products from enzyme-catalyzed oxidations of norcarenes. |
| PubMed: | Desaturase reactions complicate the use of norcarane as a mechanistic probe. Unraveling the mixture of twenty-plus products formed in enzyme-catalyzed oxidations of norcarane. |
| PubMed: | Oxygen-18 tracer studies of enzyme reactions with radical/cation diagnostic probes. |
| PubMed: | Reaction mechanisms of non-heme diiron hydroxylases characterized in whole cells. |
| PubMed: | Remarkable aliphatic hydroxylation by the diiron enzyme toluene 4-monooxygenase in reactions with radical or cation diagnostic probes norcarane, 1,1-dimethylcyclopropane, and 1,1-diethylcyclopropane. |
| PubMed: | endo/exo isomerism in norcarane and 2-norcaranol hydrotrioxides (ROOOH). |
| PubMed: | Xylene monooxygenase, a membrane-spanning non-heme diiron enzyme that hydroxylates hydrocarbons via a substrate radical intermediate. |
| PubMed: | Evaluation of norcarane as a probe for radicals in cytochome p450- and soluble methane monooxygenase-catalyzed hydroxylation reactions. |
| PubMed: | Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane. |
| PubMed: | Intermediate Q from soluble methane monooxygenase hydroxylates the mechanistic substrate probe norcarane: evidence for a stepwise reaction. |
| PubMed: | Electronic and steric factors in regioselective hydroxylation catalyzed by purified cytochrome P-450. |
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