Articles:
2-hydroxyethyl(trimethyl)azanium
Notes:
a basic constituent of lecithin that is found in many plants and animal organs. it is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. Nutritional supplement. Occurs free and combined in many animal and vegetable foods with highest concentrations found in egg yolk, meat, fish, milk, cereaks and legumes
Choline is a water-soluble essential nutrient. It is usually grouped within the B-complex vitamins. Choline generally refers to the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation. (Wikipedia)
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American International Chemical, Inc. Consistent sources North American supplier for globally sourced ingredients. AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it. Email: Info Voice: (800) 238-0001 Facebook Twitter Linkedin Products List: View Product(s): 160051 Choline
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 62-49-7 Choline
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| CAS Number: | 62-49-7 |  3D/inchi
|
| Other(deleted CASRN): | 139741-81-4 | |
| ECHA EINECS - REACH Pre-Reg: | 200-535-1 | |
| FDA UNII: | N91BDP6H0X | |
| Nikkaji Web: | J4.822D | |
| Beilstein Number: | 1736748 | |
| MDL: | MFCD00002831 | |
| XlogP3-AA: | -0.40 (est) | |
| Molecular Weight: | 104.17278000 | |
| Formula: | C5 H14 N O | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FEMA Number: | 4500 choline |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
Physical Properties:
| Food Chemicals Codex Listed: | No |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| American International Chemical, LLC. |
| Choline |
| Axsyn |
| For experimental / research use only. |
| Ethanaminium,2-hydroxy-N,N,N-trimethyl- |
| Balchem |
| Memor-C™
Flavor: characteristic Choline is an essential nutrient; it is important for the healthy structure and function of your body, acting as a chemical “building block”, an agent of cell-to-cell communication and transportation, and part of a regulatory system for your genes. |
| Balchem |
| VitaCholine™
Flavor: characteristic Choline is an essential nutrient important to the healthy structure and function of the human body. |
| BOC Sciences |
| For experimental / research use only. |
| Choline |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Choline base solution ∼50 % (w/w) in H2O |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| C - Corrosive. | |
|
R 34 - Causes burns. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-cat LDLo 35 mg/kg "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 358, 1948. intraperitoneal-guinea pig LDLo 450 mg/kg Proceedings of the Society for Experimental Biology and Medicine. Vol. 85, Pg. 642, 1954. intravenous-rabbit LDLo 70 mg/kg Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 83, Pg. 481, 1920. | |
| Dermal Toxicity: | |
|
subcutaneous-cat LDLo 150 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. subcutaneous-frog LDLo 1500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. subcutaneous-rabbit LDLo 500 mg/kg "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 358, 1948. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for choline usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 24. Update in publication number(s): 26 | |||
| Click here to view publication 24 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 4000.00000 | 6000.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | 4000.00000 | 6000.00000 | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | 600.00000 | 1200.00000 | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | 4000.00000 | 6000.00000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 4000.00000 | 6000.00000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | 4000.00000 | 6000.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | 4000.00000 | 6000.00000 | |
| snack foods: | 4000.00000 | 6000.00000 | |
| soft candy: | - | - | |
| soups: | 2500.00000 | 4000.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Literature search and review related to specific preparatory work in the establishment of Dietary References Values for Thiamin, Pantothenic Acid and Choline View page or View pdf | |
| Scientific Opinion on the substantiation of a health claim related to choline and "development of brain" pursuant to Article 14 of Regulation (EC) No 1924/2006 View page or View pdf | |
| Dietary Reference Values for choline View page or View pdf | |
| Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for choline View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 62-49-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 305 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 3267 |
| WGK Germany: | 3 |
| 2-hydroxyethyl(trimethyl)azanium | |
| Chemidplus: | 0000062497 |
References:
| 2-hydroxyethyl(trimethyl)azanium | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 62-49-7 |
| Pubchem (cid): | 305 |
| Pubchem (sid): | 134971369 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00114 |
| HMDB (The Human Metabolome Database): | HMDB00097 |
| FooDB: | FDB000710 |
| YMDB (Yeast Metabolome Database): | YMDB00227 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
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Synonyms:
| bilineurine | |
| biocoline | |
| choline base solution | |
| choline cation | |
| choline ion | |
| cholinum | |
| ethanaminium,2-hydroxy-N,N,N-trimethyl- | |
| hepacholine | |
| hormocline | |
| 2- | hydroxyethyl(trimethyl)azanium |
| (2- | hydroxyethyl)trimethyl ammonium |
| (2- | hydroxyethyl)trimethylammonium |
| (beta- | hydroxyethyl)trimethylammonium |
| lipotril | |
| nemor-C | |
| neocolina | |
| vitacholine |