olestra
sucrose polyester
 
Notes:
non-absorbable, non-digestable fat-like mixture of hexa-, hepta-, octaesters of sucrose with long chain fatty acids; proposed hypocholesteremic agent. Nondigestible fat substitute for low-calorie food Olestra (also known by its brand name Olean) is a fat substitute that adds no fat, calories, or cholesterol to products. It has been used in the preparation of traditionally high-fat foods such as potato chips, thereby lowering or eliminating their fat content.
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CAS Number: 121854-29-3 
FDA UNII: 6742Y30KGK
Category: used in place of fats and oils
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 325 Olestra View - notice PDF
GRN 227 Olestra View - notice PDF
FDA Mainterm (SATF):121854-29-3 ; OLESTRA
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.867 Olestra.
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: used in place of fats and oils
Recommendation for olestra usage levels up to:
 not for fragrance use.
 
Recommendation for olestra flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety of sucrose esters of fatty acids prepared from vinyl esters of fatty acids and on the extension of use of sucrose esters of fatty acids in flavourings
View page or View pdf
ClinicalTrials.gov: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0121854293
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References:
Pubchem (sid): 135321769
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): Search
FooDB: FDB021085
FDA Listing of Food Additive Status: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 sucrose polyester
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Articles:
PubMed: Intervention to reduce PCBs: learnings from a controlled study of Anniston residents.
PubMed: Detox diets for toxin elimination and weight management: a critical review of the evidence.
PubMed: Vitamin d bioavailability: state of the art.
PubMed: Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial.
PubMed: Review of the effects of dilution of dietary energy with olestra on energy intake.
PubMed: Fat substitutes promote weight gain in rats consuming high-fat diets.
PubMed: mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals.
PubMed: Intraperitoneal injections as a possible means of generating varied levels of methylmercury in the eggs of birds in field studies.
PubMed: Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations: results from two pilot studies.
PubMed: The effect of olestra on the absorption, excretion and storage of 2,2',5,5' tetrachlorobiphenyl; 3,3',4,4' tetrachlorobiphenyl; and perfluorooctanoic acid.
PubMed: Fat and sugar flavor preference and acceptance in C57BL/6J and 129 mice: experience attenuates strain differences.
PubMed: Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations.
PubMed: Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male.
PubMed: Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoids.
PubMed: Dioxin toxicity and chloracne in the Ukraine.
PubMed: Dietary fat and obesity: a review of animal, clinical and epidemiological studies.
PubMed: Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene.
PubMed: A novel, noninvasive method for the measurement of intestinal fat absorption.
PubMed: Olestra labeling change.
PubMed: Number of days, number of subjects, and sources of variation in longitudinal intervention or crossover feeding trials with multiple days of measurement.
PubMed: Consumption of a controlled low-fat diet containing olestra for 9 months improves health risk factors in conjunction with weight loss in obese men: the Ole' Study.
PubMed: Olestra: targetless arrow?
PubMed: Is olestra consumption associated with changes in dietary intake, serum lipids, and body weight?
PubMed: Health risks, past usage, and intention to use weight loss products in normal weight women with high and low body dysphoria.
PubMed: Severe gastrointestinal illness associated with olestra ingestion.
PubMed: Authors' financial relationships with the food and beverage industry and their published positions on the fat substitute olestra.
PubMed: Modifications in cyclosporine (CsA) microemulsion blood concentrations by olestra.
PubMed: [Diet therapy in chronic inflammatory bowel disease: results from meta-analysis and randomized controlled trials].
PubMed: Intestinal alkaline phosphatase release is not associated with chylomicron formation.
PubMed: A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study.
PubMed: A role for olestra in body weight management.
PubMed: Severe 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients.
PubMed: Effect on body weight of replacing dietary fat with olestra for two or ten weeks in healthy men and women.
PubMed: Additive gastrointestinal effects with concomitant use of olestra and orlistat.
PubMed: [Inhibitors of absorption as anti-obesity drugs].
PubMed: Randomized, double-blind, placebo-controlled, food allergy challenge to olestra snacks.
PubMed: The effect of ingesting olestra-based foods on feeding behavior and energy balance in humans.
PubMed: "You ate all that!?": caretaker-child interaction during children's assisted dietary recall interviews.
PubMed: Postmarketing surveillance of new food ingredients: results from the program with the fat replacer olestra.
PubMed: Postmarketing surveillance of new food ingredients: design and implementation of the program for the fat replacer olestra.
PubMed: A brief dietary assessment instrument for assessing target foods, nutrients and eating patterns.
PubMed: 8:45-90:00. The Influence of a High Fat Meal Compared to an Olestra Meal on Coronary Artery Endothelial Dysfunction by Rubidium (Rb)-82 Positron Emission Tomography (PET) and on Post Prandial Serum Triglycerides.
PubMed: Effects of dietary fat, nutrition labels, and repeated consumption on sensory-specific satiety.
PubMed: Changes in diet, weight, and serum lipid levels associated with olestra consumption.
PubMed: Olestra consumption does not predict serum concentrations of carotenoids and fat-soluble vitamins in free-living humans: early results from the sentinel site of the olestra post-marketing surveillance study.
PubMed: Effects of wheat bran and Olestra on objective measures of stool and subjective reports of GI symptoms.
PubMed: Caretaker-child interaction during children's 24-hour dietary recalls: who contributes what to the recall record?
PubMed: Effects of dietary fibre and olestra on regional apparent viscosity and water content of digesta residue in porcine large intestine.
PubMed: Effects of olestra and sorbitol consumption on objective measures of diarrhea: impact of stool viscosity on common gastrointestinal symptoms.
PubMed: Olestra consumption is not associated with macular pigment optical density in a cross-sectional volunteer sample in Indianapolis.
PubMed: Positive results on tests for steatorrhea in persons consuming olestra potato chips.
PubMed: Early adopters of olestra-containing foods: who are they?
PubMed: Olestra snacks compared with regular snacks.
PubMed: Effect of the moderate consumption of olestra in patients receiving long-term warfarin therapy.
PubMed: Olestra formulation and the gastrointestinal tract.
PubMed: Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
PubMed: Does intraduodenal administration of sucrose polyester (Olestra) cause satiation in humans?
PubMed: Vitamin K-supplemented snacks containing olestra: implication for patients taking warfarin.
PubMed: Comparison of effects on colonic motility and stool characteristics associated with feeding olestra and wheat bran to ambulatory mini-pigs.
PubMed: [Fat substitutes in human diet].
PubMed: A non-absorbable dietary fat substitute enhances elimination of persistent lipophilic contaminants in humans.
PubMed: Current concepts in the pharmacological management of obesity.
PubMed: Gastric emptying of indigestible versus digestible oils and solid fats in normal humans.
PubMed: Procter & Gamble responds on olestra.
PubMed: Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: baseline results from the sentinel site of the Olestra Post-Marketing Surveillance Study.
PubMed: Transient overconsumption of novel foods by deafferentated rats: effects of novel diet composition.
PubMed: Gastrointestinal symptoms in 3181 volunteers ingesting snack foods containing olestra or triglycerides. A 6-week randomized, placebo-controlled trial.
PubMed: Review article: olestra and its gastrointestinal safety.
PubMed: The selling of olestra.
PubMed: Olestra Postmarketing Surveillance Study: design and baseline results from the sentinel site.
PubMed: Sounding the alarm for misuse of olestra-containing foods in binge-eating disorders.
PubMed: Effect of fat-free potato chips with and without nutrition labels on fat and energy intakes.
PubMed: Gastrointestinal symptoms following olestra consumption.
PubMed: Determination of fat in olestra-containing savory snack products by capillary gas chromatography.
PubMed: Effects of 14 d of covert substitution of olestra for conventional fat on spontaneous food intake.
PubMed: Poor digestibility of fully hydrogenated soybean oil in rats: a potential benefit of hydrogenated fats and oils.
PubMed: Olestra: a new food additive.
PubMed: Overview of olestra: a new fat substitute.
PubMed: Olestra at the movies.
PubMed: Small portions of olestra OK.
PubMed: Gastrointestinal symptoms following consumption of olestra or regular triglyceride potato chips: a controlled comparison.
PubMed: A randomized, double-blind study of the effect of olestra on disease activity in patients with quiescent inflammatory bowel disease. Olestra in IBD Study Group.
PubMed: Review and analysis of the effects of olestra, a dietary fat substitute, on gastrointestinal function and symptoms.
PubMed: Randomized, double-blind, placebo-controlled, consumer rechallenge test of Olean salted snacks.
PubMed: Comparison of olestra absorption in guinea pigs with normal and compromised gastrointestinal tracts.
PubMed: Assessment of the nutritional effects of olestra.
PubMed: Olestra, a nonabsorbed, noncaloric replacement for dietary fat: a review.
PubMed: Assessment of the nutritional effects of olestra, a nonabsorbed fat replacement: summary.
PubMed: An indirect means of assessing potential nutritional effects of dietary olestra in healthy subgroups of the general population.
PubMed: Evaluation of the potential for olestra to affect the availability of dietary phytochemicals.
PubMed: Olestra ingestion and dietary fat absorption in humans.
PubMed: Olestra ingestion and retinyl palmitate absorption in humans.
PubMed: Olestra's effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins.
PubMed: Olestra dose response on fat-soluble and water-soluble nutrients in humans.
PubMed: Olestra affects serum concentrations of alpha-tocopherol and carotenoids but not vitamin D or vitamin K status in free-living subjects.
PubMed: Nutritional status of pigs fed olestra with and without increased dietary levels of vitamins A and E in long-term studies.
PubMed: Olestra's effect on the status of vitamins A, D and E in the pig can be offset by increasing dietary levels of these vitamins.
PubMed: Olestra dose response on fat-soluble and water-soluble nutrients in the pig.
PubMed: Physical or temporal separation of olestra and vitamins A, E and D intake decreases the effect of olestra on the status of the vitamins in the pig.
PubMed: The domestic pig as a model for evaluating olestra's nutritional effects.
PubMed: Estimated consumption and eating frequency of olestra from savory snacks using menu census data.
PubMed: Assessment of the nutritional effects of olestra, a nonabsorbed fat replacement: introduction and overview.
PubMed: From the Miocene to olestra: a historical perspective on fat consumption.
PubMed: Olestra: assessing its potential to interact with drugs in the gastrointestinal tract.
PubMed: Sensory properties of a nonabsorbable fat substitute did not affect regulation of energy intake.
PubMed: Genotoxicity and subchronic toxicity studies with heated olestra.
PubMed: Olestra and the FDA.
PubMed: Olestra and the FDA.
PubMed: Olestra and the FDA.
PubMed: Olestra and the FDA.
PubMed: Disposition of ingested olestra in weanling mini-pigs.
PubMed: Degradation of olestra, a non caloric fat replacer, by microorganisms isolated from activated sludge and other environments.
PubMed: Replacement of dietary fat with sucrose polyester: effects on energy intake and appetite control in nonobese males.
PubMed: Olestra and the FDA.
PubMed: The trials of olestra: is a fat-free lunch too costly?
PubMed: Lipid-based fat substitutes.
PubMed: The effect of olestra on breath gas production and faecal microbial counts.
PubMed: Utilization of hydrolyzed sucrose polyester (olestra) in broiler diets.
PubMed: Disposition of ingested olestra in the Fischer 344 rat.
PubMed: Chronic toxicity and carcinogenicity of olestra in Swiss CD-1 mice.
PubMed: Liquid chromatographic method for determining the percent of olestra in lipid samples.
PubMed: A comparison of the effect of olestra and triglyceride on postprandial esophageal acid exposure.
PubMed: Olestra, a nondigestible, nonabsorbable fat. Effects on gastrointestinal and colonic transit.
PubMed: Effects of olestra, a noncaloric fat substitute, on daily energy and fat intakes in lean men.
PubMed: Safety evaluation of olestra, a nonabsorbed, fatlike fat replacement.
PubMed: The excretion and characterization of intravenously administered olestra.
PubMed: A 20-month olestra feeding study in dogs.
PubMed: Serum 25-hydroxyvitamin D concentrations of free-living subjects consuming olestra.
PubMed: Analysis of liver tissue for olestra following long-term feeding to rats and monkeys.
PubMed: Chronic toxicity and carcinogenicity studies of olestra in Fischer 344 rats.
PubMed: Vitamin K status of free-living subjects consuming olestra.
PubMed: Olestra and potential role of a nonabsorbable lipid in the diets of children.
PubMed: Effects of partial replacement of dietary fat by olestra on dietary cholesterol absorption in man.
PubMed: The effect of olestra on systemic levels of oral contraceptives.
PubMed: A 91-day feeding study in rats with heated olestra/vegetable oil blends.
PubMed: Evaluation of olestra in short-term genotoxicity assays.
PubMed: FYI: more news about Olestra.
PubMed: Influence of absorbable and nonabsorbable lipids and lipidlike substances on drug bioavailability.
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